Results 11 to 20 of about 196,000 (337)

Pd(II)–NHC (NHC = N‐Heterocyclic Carbene)‐Catalyzed Alkylation of Primary Amides by Site‐Selective N─C(O) Activation [PDF]

Advanced Science
Although over the past decade, there have been tremendous advances in amide bond cross‐coupling, one of the major remaining challenges is selective alkylation of ubiquitous primary amides.
Peng Lei, Yuge Hu, Deshuang Zhang, Jiuhui Ye, Yanqing Gao, Juntao Feng, Zhiqing Ma, Xili Liu, Michal Szostak   +8 more
doaj   +2 more sources

Ketone α-alkylation at the more-hindered site

Nature Communications, 2023
Control of the regioselectivity of α-alkylation of carbonyl compounds is a longstanding topic of research in organic chemistry. By using stoichiometric bulky strong bases and carefully adjusting the reaction conditions, selective alkylation of ...
Ming-Ming Li, Tianze Zhang, Lei Cheng, Wei-Guo Xiao, Jin-Tao Ma, Li-Jun Xiao, Qi-Lin Zhou   +6 more
doaj   +1 more source

Versatile cell-based assay for measuring DNA alkylation damage and its repair

Scientific Reports, 2021
DNA alkylation damage induced by environmental carcinogens, chemotherapy drugs, or endogenous metabolites plays a central role in mutagenesis, carcinogenesis, and cancer therapy.
Yong Li, Peng Mao, Evelina Y. Basenko, Zachary Lewis, Michael J. Smerdon, Wioletta Czaja   +5 more
doaj   +1 more source

Alkyl–Alkyl Suzuki Cross‐Coupling of Unactivated Secondary Alkyl Chlorides [PDF]

Angewandte Chemie, 2010
The first method for achieving alkyl–alkyl Suzuki reactions of unactivated secondary alkyl chlorides has been developed. Carbon–carbon bond formation occurs under mild conditions (at room temperature) with the aid of commercially available catalyst components.
Lu, Zhe, Fu, Gregory C.
openaire   +5 more sources

Selective nucleophilic α-C alkylation of phenols with alcohols via Ti=Cα intermediate on anatase TiO2 surface

Nature Communications, 2023
C−C bond forming reaction by alkylation of aryl rings is a main pillar of chemistry in the production of broad portfolios of chemical products. The dominant mechanism proceeds via electrophilic substitution of secondary and tertiary carbocations over ...
Xinze Du, Hongjun Fan, Shenglin Liu, Z. Conrad Zhang   +3 more
doaj   +1 more source

Enhancing the side-chain alkylation of toluene with methanol to styrene over the Cs-modified X zeolite by the assistance of basic picoline as a co-catalyst

Green Energy & Environment, 2022
Side-chain alkylation of toluene with methanol is a green pathway to realize the one-step production of styrene under mild conditions, but the low selectivity of styrene is difficult to be improved with by-products of ethylbenzene and xylene.
Zhe Hong, Guoqing Zhao, Fangtao Huang, Xiaoxia Wang, Zhirong Zhu   +4 more
doaj   +1 more source

Some applications of deep eutectic solvents in alkylation of heterocyclic compounds: A review of the past 10 years

Heterocyclic Communications, 2021
This mini-review encapsulates the latest findings (past 10 years) in the field of the deep eutectic solvents (DESs) application in the alkylation/arylation of different heterocyclic compounds.
Molnar Maja, Lončarić Melita, Jakovljević Martina, Komar Mario, Lončar Mirjana   +4 more
doaj   +1 more source

Copper(I)-catalyzed asymmetric alkylation of α-imino-esters

Nature Communications, 2023
Asymmetric alkylation of enolates is one of the most direct and important reactions to prepare α-chiral carbonyl compounds. Except for the classical methods that rely on the use of chiral auxiliaries, asymmetric catalysis emerged as a powerful tool ...
Zong-Ci Liu, Zi-Qing Wang, Xuan Zhang, Liang Yin   +3 more
doaj   +1 more source

Kinetic modeling of liquid phase catalytic alkylation of guaiacol with cyclohexene

Chemical Engineering Journal Advances, 2021
The kinetics of the liquid-phase alkylation of guaiacol (G) with cyclohexene (CH) over Amberlyst 36 resin was studied using Langmuir–Hinshelwood–Hougen–Watson (LHHW) heterogeneous kinetic models.
Mardelly Kateryne Montañez-Valencia, Cristina Liliana Padró, María Eugenia Sad, Nicolás Maximiliano Bertero   +3 more
doaj   +1 more source

Regioselective Reactions of Highly Substituted Arynes [PDF]

, 2010
The fully regioselective reactivity of four new highly substituted silyl aryl triflate aryne precursors in aryne acyl-alkylation, acyl-alkylation/condensation, and heteroannulation reactions is reported.
Bugga, Pradeep, Gilmore, Christopher D., Stoltz, Brian M., Tadross, Pamela M., Virgil, Scott C.   +4 more
core   +2 more sources