TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy [PDF]
, 2013 Base damage and topoisomerase I (Top1)-linked DNA breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlying the cytotoxicity of a wide range of anti-cancer agents.
Alagoz +50 more
core +1 more source
Tunable, Functional Diblock Copolypeptide Hydrogels Based on Methionine Homologs. [PDF]
, 2020 The preparation of new diblock copolypeptide hydrogels derived from homologs of l-methionine, that is, l-homomethionine and l-6-(methylthio)-l-norleucine is described.
Deming, Timothy J +2 more
core +1 more source
ALKYLATION OF BENZENE WITH LONG CHAIN OLEFINS OVER SOLID-ACID CATALYST
Journal of Engineering, 2009 This investigation is concerned with the linear alkylbenzene production reaction by the alkylation of benzene with long chain olefins C10-C13 over various prepared solid acid catalysts.
Abdul Halim A. K. Mohammed +1 more
doaj +1 more source
Synthesis of tetrahydrokhusitone: Annulation of the cyclohexane ring by free radical and carbanionic sequence of reactions [PDF]
Journal of the Serbian Chemical Society, 2003 The synthesis of norcadinane sesquiterpene tetrahydrokhusitone 1 has been achieved by a new method for annulation of cyclohexane ring involving a sequence of free radical δ-alkylation of the non-activated carbon atom and intramolecular carbanionic ...
Petrović Goran, Čeković Živorad
doaj +1 more source
Unanticipated differences between α- and γ-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates [PDF]
, 2006 Hairpin polyamide–chlorambucil conjugates containing an {alpha}-diaminobutyric acid ({alpha}-DABA) turn moiety are compared to their constitutional isomers containing the well-characterized {gamma}-DABA turn.
Chou, C. James +4 more
core +4 more sources
3-(2-Diisopropylaminoethyl)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione
Molbank, 2022 Thiazolidine-2,4-dione core is widely used in the medicinal chemistry of different types of potential drug-like small molecules. In the present work, the synthesis of a novel non-condensed thiazolidine-2,4-dione-bearing derivative is reported by the two ...
Serhii Holota +3 more
doaj +1 more source
Poly(thioether) vitrimers via transalkylation of trialkylsulfonium salts [PDF]
, 2017 Vitrimers are permanently cross-linked organic polymers that can be reshaped, molded, and recycled without loss of network integrity. Herein, we report poly(thioether) networks, prepared through a straightforward thiol-ene photopolymerization, that can ...
Hendriks, Benjamin +3 more
core +1 more source
Meitan kexue jishu, 2023 Coal-tar pitch (CTP) is a substance produced by ambient and/or vacuum distillation of high-temperature coal tar, although CTP has a large yield in China, however its wide application is limited due to its high toxicity.
ZHANG Wenshuo +5 more
doaj +1 more source
Chemical, Electronic, and Electrical Properties of Alkylated Ge(111) Surfaces [PDF]
, 2010 The use of Ge in semiconductor electronics has been constrained by the lack of a simple method of passivating the crystal surface. Toward that end, we have explored the utility of chemically bonded hydrocarbon monolayers.
Brunschwig, Bruce S. +2 more
core +2 more sources
Regioselective Alkylation of an Oxonaphthalene-Annelated Pyrrol System
Molbank, 2009 The regioselective alkylation of an oxonaphthalene-annelated pyrrole system is reported. The regioselectivity of alkylation can be controlled by the selection of the solvent.
Helmut Spreitzer, Christiane Puschmann
doaj +1 more source