Umpolung Synthesis of Pyridyl Ethers by BiV‐Mediated O‐Arylation of Pyridones
Angewandte Chemie, Volume 134, Issue 51, December 19, 2022., 2022 We demonstrate that sterically‐ and electronically‐diverse pyridyl ethers can be accessed via BiV‐mediated C−O coupling of 2‐ or 4‐pyridones with arylboronic acids. Use of a bismacyclic reagent not only confers modularity on our methodology, but also results in highly regioselective O‐arylation that is unprecedented for BiV.
Katie Ruffell +4 more
wiley +2 more sources
Tunneling conductance of amine linked alkyl chains [PDF]
Nano Lett 8, 1771 (2008), 2008 The tunneling transport theory developed in Phys. Rev. B {\bf 76}, 115102 (2007) is applied to molecular devices made of alkyl chains linked to gold electrodes via amine groups. Using the analytic expression of the tunneling conductance derived in our previous work, we identify the key physical quantities that characterize the conductance of these ...
arxiv +1 more source
Computational Investigations of Selected Enzymes From Two Iron and α-ketoglutarate-Dependent Families [PDF]
, 2021 DNA alkylation is used as the key epigenetic mark in eukaryotes, however, most alkylation in DNA can result in deleterious effects. Therefore, this process needs to be tightly regulated. AlkB and TET are families within the Fe and $\alpha$-kg-dependent superfamily of enzymes that are tasked with dealkylating DNA and RNA in cells.
arxiv +1 more source
Unanticipated differences between α- and γ-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates [PDF]
, 2006 Hairpin polyamide–chlorambucil conjugates containing an {alpha}-diaminobutyric acid ({alpha}-DABA) turn moiety are compared to their constitutional isomers containing the well-characterized {gamma}-DABA turn.
Chou, C. James +4 more
core +4 more sources
Angewandte Chemie, Volume 134, Issue 51, December 19, 2022., 2022 Introduced as the first explicitly tetrel‐centered cascade exchangers, Michael acceptors are shown to enable and inhibit thiol‐mediated uptake, generate distinct patterns in heatmaps to decode uptake circuitry, integrate novel halogen‐bonding switches, deliver proteins to the cytosol, and break, as dimers, records for uptake inhibition related to drug ...
Inga Shybeka +5 more
wiley +2 more sources
Regioselective Alkylation of an Oxonaphthalene-Annelated Pyrrol System
Molbank, 2009 The regioselective alkylation of an oxonaphthalene-annelated pyrrole system is reported. The regioselectivity of alkylation can be controlled by the selection of the solvent.
Helmut Spreitzer, Christiane Puschmann
doaj +1 more source
Covalent binding studies on the 14C-labeled antitumour compound 2,5-bis(1-aziridinyl)-1,4-benzoquinone. Involvement of semiquinone radical in binding to DNA, and binding to proteins and bacterial macromolecules in situ [PDF]
, 1990 2,5-Bis(1-aziridinyl)-1,4-benzoquinone (BABQ) is a compound from which several antitumour drugs are derived, such as Trenimone, Carboquone and Diaziquone (AZQ).
Egberink, Richard J.M. +5 more
core +2 more sources
Dual Catalytic Platform for Enabling sp3 α C–H Arylation and Alkylation of Benzamides
, 2020 A dual catalytic sp3 α C–H arylation and alkylation of benzamides with organic halides is described.
A. W. Rand +7 more
semanticscholar +1 more source
Effect of alkyl substituents on the adsorption of thienylenevinylene oligomers on the Si (100) surface [PDF]
Surface Science 473, 1-2 (2001) 1-7, 2012 The adsorption of thienylenevinylene oligomers on the Si(100) surface has been investigated using scanning tunneling microscopy. The mode of substitution of the thiophene ring exerts a strong influence on the adsorption configurations and the images of the oligomer based on 3,4-dihexyl thiophene are highly voltage dependent. We discuss the influence of
arxiv +1 more source
Merging Photoredox Catalysis with Organocatalysis: The Direct Asymmetric Alkylation of Aldehydes
Science, 2008 Photoredox catalysis and organocatalysis represent two powerful fields of molecule activation that have found widespread application in the areas of inorganic and organic chemistry, respectively.
David A. Nicewicz, D. MacMillan
semanticscholar +1 more source