Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations
Molecules, 2009 Alkylation is a very important chemical reaction which modifies the biological properties of drugs. Quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties.We now report application of a practical ...
Martha Cecilia Meza +4 more
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Asymmetric synthesis of 2-substituted oxetan-3-ones via metalated SAMP/RAMP hydrazones [PDF]
, 2013 2-Substituted oxetan-3-ones can be prepared in good yields and enantioselectivities (up to 84% ee) by the metalation of the SAMP/RAMP hydrazones of oxetan-3-one, followed by reaction with a range of electrophiles that include alkyl, allyl, and benzyl ...
Beasley, Benjamin +3 more
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Direct C2–H alkylation of indoles driven by the photochemical activity of halogen-bonded complexes
Beilstein Journal of Organic Chemistry, 2023 A light-driven metal-free protocol for the synthesis of sulfone-containing indoles under mild conditions is reported. Specifically, the process is driven by the photochemical activity of halogen-bonded complexes formed upon complexation of a sacrificial ...
Martina Mamone +4 more
doaj +1 more source
On the prevalence of bridged macrocyclic pyrroloindolines formed in regiodivergent alkylations of tryptophan. [PDF]
, 2016 A Friedel-Crafts alkylation is described that efficiently transforms tryptophan-containing peptides into macrocycles of varying ring connectivity. Factors are surveyed that influence the distribution of regioisomers, with a focus on indole C3-alkylations
Curtin, Brice H +5 more
core +1 more source
Structure and function prediction of human homologue hABH5 of _E. coli_ ALKB5 using in silico approach [PDF]
, 2011 Newly discovered human homologues of ALKB protein have shown the activity of DNA damaging drugs, used for cancer therapy. Little is known about the structure and function of hABH5, one of the members of this superfamily.
Ambarish Sharan Vidyarthi +3 more
core +5 more sources
The NADPH-Dependent thioredoxin reductase C-2-Cys peroxiredoxin redox system modulates the activity of thioredoxin x in arabidopsis chloroplasts [PDF]
, 2018 The chloroplast redox network is composed of a complex set of thioredoxins (Trxs), reduced by ferredoxin (Fdx) via a Fdx-dependent Trx reductase (FTR), and an NADPH-dependent Trx reductase with a joint Trx domain, NTRC, which efficiently reduces 2-Cys ...
Cejudo Fernández, Francisco Javier +2 more
core +1 more source
Green CarbonThe direct alkylation of benzene with alkanes is an effective method for alkylbenzene production. Our group previously discovered that a mixture of supported Pd nanoparticles and solid acids effectively promoted the alkylation of benzene with alkanes ...
Satoshi Misaki +5 more
doaj +1 more source
Redox Biology, 2013 Cigarette smoking remains a major health concern worldwide, and many of the adverse effects of cigarette smoke (CS) can be attributed to its abundant electrophilic aldehydes, such as acrolein (2-propenal).
Matthew J. Randall +4 more
doaj +1 more source
Direct C(sp2)–H alkylation of unactivated arenes enabled by photoinduced Pd catalysis
Nature Communications, 2020 Direct catalytic C(sp2)–H alkylation of unactivated arenes with alkyl halides remains elusive despite the progress in C-H functionalization. Here, the authors report the catalytic C(sp2)–H alkylation of unactivated arenes with alkyl bromides via visible ...
Daeun Kim +3 more
doaj +1 more source
Dinuclear platinum(II) sulfide–thiolate complexes [Pt₂(μ-S)(μ-SR)(PPh₃)₄]⁺ containing fluorinated substituents and the identification of a SC₆F₅ π interaction in the crystal structure of [Pt₂(μ-S)(μ-SCH₂C₆F₅)(PPh₃)₄]BPh₄•2C₆H₆ [PDF]
, 2011 Reactions of the platinum(II) sulfido complex [Pt₂(μ-S)₂(PPh₃)₄] with the alkyl iodides ICH₂CH₂(CF₂)nCF₃ (n = 3, 7) gives good yields of the monoalkylated products [Pt₂(μ-S){μ-SCH₂CH₂(CF₂)nCF₃}(PPh₃)₄]⁺, which were isolated as PF₆⁺or BPH₄⁻ salts, and ...
Henderson, William +2 more
core +2 more sources