Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia. [PDF]
PLoS ONE, 2015 Allopurinol, an inhibitor of xanthine oxidase, has been used in clinical trials of patients with cardiovascular and chronic kidney disease. These are two pathologies with extensive links to hypoxia and activation of the transcription factor hypoxia ...
Yu Sun +3 more
doaj +18 more sources
Molecular Oncology, 2019 The ability to predict responsiveness to drugs in individual patients is limited. We hypothesized that integrating molecular information from databases would yield predictions that could be experimentally tested to develop transcriptomic signatures for ...
Iman Tavassoly +11 more
doaj +2 more sources
Association between allopurinol and hepatocellular carcinoma: analysis of genetic risk and patient survival [PDF]
Discover OncologyBackground Despite the widespread clinical use of allopurinol for managing hepatocellular carcinoma (HCC) and gout, its potential hepatotoxicity and its effect on the risk of HCC remain unclear.
Yu-fu Li +6 more
doaj +2 more sources
Lesinurad in combination with allopurinol: a randomised, double-blind, placebo-controlled study in patients with gout with inadequate response to standard of care (the multinational CLEAR 2 study). [PDF]
Annals of the Rheumatic Diseases, 2016 Determine the efficacy and safety of daily lesinurad (200 or 400 mg orally) added to allopurinol in patients with serum uric acid (sUA) above target in a 12-month, randomised, phase III trial.
Adler, S. +9 more
core +2 more sources
Allopurinol: Sorrow to the marrow
Journal of Family Medicine and Primary Care, 2020 Allopurinol is a xanthine oxidase inhibitor used in management of chronic gout. It acts by reducing the amount of uric acid by inhibiting purine metabolism.
U R Raaju, Siddharth Gosavi, K Sriharsha
doaj +3 more sources
Treatment of Gout with Allopurinol and Sulphinpyrazone in Combination and with Allopurinol Alone [PDF]
Annals of the Rheumatic Diseases, 1966 William C. Kuzell +3 more
openalex +5 more sources
Allopurinol use and risk of acute coronary syndrome in gout patients: a population-based cohort study in Sweden [PDF]
BMJ OpenObjectives To investigate the impact of allopurinol use on the risk of first-ever acute coronary syndrome (ACS) event in patients with gout.Methods Using national and regional register data, we included all patients with a gout diagnosis at primary or ...
Ulf Lindström +5 more
doaj +2 more sources
Effectiveness of Allopurinol on Uric Acid and Pediatric Chronic Kidney Disease Severity in the Chronic Kidney Disease in Children Study [PDF]
Kidney MedicineRationale & Objective: Clinical trials have shown that serum uric acid reduction does not slow chronic kidney disease (CKD) progression in adults, but it is uncertain whether these findings apply to children.
Derek K. Ng +5 more
doaj +1 more source
The anti-inflammatory effect of allopurinol and diclofenac in chicks’ model [PDF]
Iraqi Journal of Veterinary Sciences, 2023 No studies have been conducted on the anti-inflammatory effect of allopurinol; eight-day old chicks are used. The aim of this paper was to study the anti-inflammatory action of allopurinol on a chemical pain model, both when administered alone or in ...
Maab A. Fadel, Khayrea A. Mustafa
doaj +1 more source