Results 1 to 10 of about 61,179 (292)
An association study of ABCG2 rs2231142 on the concentrations of allopurinol and its metabolites
Clinical and Translational Science, 2022 ABCG2 is a gene that codes for the human breast cancer resistance protein (BCRP). It is established that rs2231142 G>T, a single nucleotide polymorphism of the ABCG2 gene, is associated with gout and poor response to allopurinol, a uric acid‐lowering ...
Marc‐Olivier Pilon +11 more
doaj +2 more sources
Effects of Allopurinol on the Progression of Chronic Kidney Disease
New England Journal of Medicine, 2020 BACKGROUND Elevated serum urate levels are associated with progression of chronic kidney disease. Whether urate-lowering treatment with allopurinol can attenuate the decline of the estimated glomerular filtration rate (eGFR) in patients with chronic ...
Sunil V Badve +2 more
exaly +2 more sources
Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes
New England Journal of Medicine, 2020 BACKGROUND Higher serum urate levels are associated with an increased risk of diabetic kidney disease. Lowering of the serum urate level with allopurinol may slow the decrease in the glomerular filtration rate (GFR) in persons with type 1 diabetes and ...
Alessandro Doria +2 more
exaly +2 more sources
Allopurinol Induction on Histopathological Structure of the Liver in Male Mice (Mus musculus)
Jurnal Biodjati, 2022 Allopurinol is used to reduce total uric acid levels in the body into oxypurinol which can inhibit xanthine oxidase. Allopurinol inhibits the precursors of uric acid formation, xanthine, and hypoxanthine.
Dian Fita Lestari +3 more
doaj +3 more sources
Molecular Oncology, 2019 The ability to predict responsiveness to drugs in individual patients is limited. We hypothesized that integrating molecular information from databases would yield predictions that could be experimentally tested to develop transcriptomic signatures for ...
Iman Tavassoly +11 more
doaj +2 more sources
Arthritis and Rheumatology, 2017 Lesinurad is a selective uric acid reabsorption inhibitor used for the treatment of gout in combination with a xanthine oxidase inhibitor. The Combining Lesinurad with Allopurinol Standard of Care in Inadequate Responders (CLEAR 1) study, a 12‐month ...
Kenneth G Saag
exaly +2 more sources
Jurnal Kimia Sains dan Aplikasi, 2019 Allopurinol sebagai obat tablet banyak beredar di pasaran, sehingga kadar allopurinol haruslah memenuhi persyaratan agar kualitas obat dijamin. Pada penelitian ini, validasi metode penentuan obat tablet allopurinol dalam tiga konsentrasi HCl, yaitu 0,05 ...
Suprianto Suprianto +3 more
doaj +3 more sources
The effect of kidney function on the urate lowering effect and safety of increasing allopurinol above doses based on creatinine clearance: a post hoc analysis of a randomized controlled trial [PDF]
Arthritis Research & Therapy, 2017 Background The use of allopurinol in people with chronic kidney disease (CKD) remains one of the most controversial areas in gout management. The aim of this study was to determine the effect of baseline kidney function on safety and efficacy of ...
Lisa K. Stamp +7 more
doaj +2 more sources
HLA‒B*58:01 and skin reactions in pediatric hematology and oncology patients treated with allopurinol [PDF]
Clinical and Experimental PediatricsBackground Allopurinol is widely used to prevent hyperuricemia in patients with tumor lysis syndrome. However, its use can trigger severe cutaneous adverse reactions (SCARs) with a mortality rate of approximately 11.39%. The human leukocyte antigen (HLA)–
Parisa Maneechai +3 more
doaj +2 more sources
Arthritis and Rheumatology, 2018 Recently, the US Food and Drug Administration (FDA) issued a public safety alert, responding to the results of the now‐published Cardiovascular Safety of Febuxostat and Allopurinol in Patients With Gout and Cardiovascular Morbidities (CARES) trial.
Hyon K Choi, Tuhina Neogi, Lisa Stamp
exaly +2 more sources