Results 31 to 40 of about 26,643 (286)

Dihydro-alpha-lipoic acid has more potent cytotoxicity than alpha-lipoic acid

In Vitro Cellular & Developmental Biology - Animal, 2009
Alpha-lipoic acid has been shown to possess cancer-cell-killing activity via activation of the apoptosis pathway. In this study, the cytotoxic activities of alpha-lipoic and dihydro-alpha-lipoic acid were compared in HL-60 cells. The cell-killing activity of dihydro-alpha-lipoic acid was higher than that of alpha-lipoic acid.
Masao, Yamasaki, Akiko, Kawabe, Kentaro, Nishimoto, Harishkumar, Madhyastha, Yoichi, Sakakibara, Masahito, Suiko, Takeaki, Okamoto, Taiji, Suda, Kenzo, Uehira, Kazuo, Nishiyama   +9 more
openaire   +3 more sources

Alpha-Lipoic Acid for the Prevention of Diabetic Macular Edema [PDF]

, 2011
Introduction: To evaluate the effect of alpha-lipoic acid (ALA) on the occurrence of diabetic macular edema. Methods: Randomized, double-blind, placebo-controlled, multicenter, multinational study. Patients were randomized to the treatment group with 600
Anselm Kampik, Christos Haritoglou, Hans P. Hammes, Joachim Gerss, Michael W. Ulbig, null null   +5 more
core   +1 more source

Efficacy of the R(+)-enantiomer of alpha-lipoic acid in clinical practice

Mìžnarodnij Endokrinologìčnij Žurnal, 2021
The article presents current data from the scientific medical literature on the effective use of the R(+)-enantiomer of α-lipoic acid in various pathological conditions.
N.О. Kravchun, I.P. Dunaieva
doaj   +1 more source

BACE1 activity impairs neuronal glucose oxidation:rescue by beta-hydroxybutyrate and lipoic acid [PDF]

, 2015
Glucose hypometabolism and impaired mitochondrial function in neurons have been suggested to play early and perhaps causative roles in Alzheimer's disease (AD) pathogenesis. Activity of the aspartic acid protease, beta-site amyloid precursor protein (APP)
Arsenian, Bateman, Beal, Bielarczyk, Blass, Bogaert, Bosetti, Bouzier-Sore, Bubber, Butterworth, Casley, Casley, Caspersen, Coleman, Costantini, Danial, David L. Hamilton, DeKosky, DeKosky, Devi, Du, Fang, Forero, Fukumoto, Geula, Gibson, Giménez-Cassina, Guglielmotto, Gómez-Isla, Hager, Hamilton, Harada, Henderson, Henderson, Hirai, Holsinger, Huang, Hussain, Itoh, Jack, Jack, Jack, Jha, John A. Findlay, Johnson, Kankotia, Kawaja, Kim, Knopman, Ko, Korolainen, Lei, Li, Lustbader, Magistretti, Manczak, Martiskainen, Masdeu, Mastrogiacoma, Maurer, McKenna, Meakin, Michael L. J. Ashford, Mirshamsi, Mosconi, Mosconi, Mowrer, Mucke, Mullen, Nelson, Nilsen, Nunomura, O'Connor, Packer, Parker, Patel, Pereira, Perry, Phypers, Puglielli, Reger, Reiman, Sancheti, Shankar, Shearman, Sinha, Small, Sokoloff, Sorbi, Sowell, Swerdlow, Tyler, Vaishnavi, Vassar, Vassar, Velliquette, Vlassenko, von Kienlin, Wilkins, Wischmeyer, Wise, Xun, Yang, Yao, Yao, Zaidan, Zhang, Zhang, Zhao   +108 more
core   +6 more sources

Studying the Effect of Adding Alpha Lipoic Acid to Gabapentin to Improve Nerve Conduction Velocity and Glycemic Control of Patients with Diabetic Neuropathy (Sample of Iraqi population)

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2020
Diabetic neuropathy (DN) is the most common chronic complication of diabetes mellitus. Hyperglycemia-induced oxidative stress induces programmed cell death of nerves, which contributes to the pathology of Diabetic neuropathy. Many clinical trials depend
Rusul AbdulKareem Hadi, Mohammed Mahmood Mohammed, Isam Noori salman   +2 more
doaj   +1 more source

Clinical, biochemical, and genetic spectrum of seven patients with NFU1 deficiency [PDF]

, 2015
Disorders of the mitochondrial energy metabolism are clinically and genetically heterogeneous. An increasingly recognized subgroup is caused by defective mitochondrial iron-sulfur (Fe-S) cluster biosynthesis, with defects in 13 genes being linked to ...
Angela eHagendorff, Arnaud V Vanlander, Barbara ePlecko, Boris eRolinski, Charlotte L Alston, Christine eMakowski, Franz A Zimmermann, Holger eProkisch, Holger eProkisch, Johannes A Mayr, Joél eSmet, Lucia eAbela, Maja eHempel, Marianne eRohrbach, Peter eFreisinger, Robert W Taylor, Rudy eVan Coster, Saikat eSantra, Sara eSeneka, Stephanie eSpranger, Steven A Hardy, Thomas eMeitinger, Thomas eMeitinger, Tobias Bernd Haack, Tobias Bernd Haack, Uwe eAhting, Wolfgang eSperl   +26 more
core   +3 more sources

Safety and Efficacy of Alpha Lipoic Acid During 4 Years of Observation: A Retrospective, Clinical Trial in Healthy Subjects in Primary Prevention

Drug Design, Development and Therapy, 2020
Giuseppe Derosa,1,2 Angela D’Angelo,2 Paola Preti,1 Pamela Maffioli1 1Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; 2Laboratory of Molecular Medicine, University of Pavia, Pavia, ItalyCorrespondence: Giuseppe ...
Derosa G, D'Angelo A, Preti P, Maffioli P   +3 more
doaj  

A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation [PDF]

Arquivos de Neuro-Psiquiatria, 2003
Oxidative stress causes metabolic and structural abnormalities during reperfusion. In an animal model of electrophysiological evaluation of cerebral ischemia-reperfusion, alpha-lipoic acid effect on the oxidative stress was studied by mean absolute ...
Otoni Cardoso do Vale, Daniel Sá Roriz Fonteles, Francisco Romero Cabral, Manassés Claudino Fonteles   +3 more
doaj  

A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization [PDF]

, 2007
Background Endothelial dysfunction (ED) is functionally characterized by decreased vasorelaxation, increased thrombosis, increased inflammation, and altered angiogenic potential, has been intimately associated with the progression and severity of ...
Ceriello, Antonio, Green, Dixy E., Ihnat, Michael A., Kamat, Chandrashekhar D., Shenoy, Satyendra S, Thorpe, Jessica E, Warnke, Linda A.   +6 more
core   +3 more sources

Clinical Approaches to the Treatment of Diabetic Neuropathy

Mìžnarodnij Endokrinologìčnij Žurnal, 2014
The article is devoted to the treatment of diabetic neuropathy. The described scheme of application of preparations of alpha-lipoic (thioctic) acid. Recently in Europe and the United States conducted a series of clinical studies that have shown that the ...
A.V. Kaminsky
doaj   +1 more source