Results 31 to 40 of about 16,063 (220)

Redundant Gs-coupled serotonin receptors regulate amyloid-β metabolism in vivo [PDF]

, 2016
BACKGROUND: The aggregation of amyloid-β (Aβ) into insoluble plaques is a hallmark pathology of Alzheimer’s disease (AD). Previous work has shown increasing serotonin levels with selective serotonin re-uptake inhibitor (SSRI) compounds reduces Aβ in the ...
Cirrito, John R, Fisher, Jonathan R, Sheline, Yvette I, Tripoli, Danielle L, Wallace, Clare E   +4 more
core   +2 more sources

Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo

Neurobiology of Disease, 2009
Both the cellular prion protein (PrPc) and the amyloid precursor protein (APP) are physiologically subjected to complex proteolytic processing events. While for APP the proteinases involved – alpha-, beta- and gamma-secretase – have been identified in ...
Kristina Endres, Gerda Mitteregger, Elzbieta Kojro, Hans Kretzschmar, Falk Fahrenholz   +4 more
doaj   +1 more source

Umuhengerin Neuroprotective Effects in Streptozotocin-Induced Alzheimer’s Disease Mouse Model via Targeting Nrf2 and NF-Kβ Signaling Cascades

Antioxidants, 2021
Alzheimer’s disease (AD) is the most common type of dementia and is characterized by advanced cognitive deterioration, deposition of Aβ (amyloid-beta), and the formation of neurofibrillary tangles.
Alaa Sirwi, Nesrine S. El Sayed, Hossam M. Abdallah, Sabrin R. M. Ibrahim, Gamal A. Mohamed, Ali M. El-Halawany, Martin K. Safo, Nora O. Abdel Rasheed   +7 more
doaj   +1 more source

The role of the Amyloid Precursor Protein mutations and PERK-dependent signaling pathways in the pathogenesis of Alzheimer’s disease [PDF]

, 2016
Alzheimer’s disease (AD) is a highly complex, progressive, age-related neurodegenerative human disease entity. The genetic basis of AD is strictly connected with occurrence of mutations in Amyloid Precursor (APP) gene on chromosome 21.
Diehl, J. Alan, Lewko, Dawid, Majsterek, Ireneusz, Nowak, Alicja, Pytel, Dariusz, Rozpędek, Wioletta   +5 more
core   +2 more sources

Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity [PDF]

, 2013
The NAD+-dependent deacetylase SIRT1 is involved in diverse cellular processes, and has also been linked with multiple disease states. Among these, SIRT1 expression negatively correlates with cancer survival in both laboratory and clinical studies ...
Chen GL, Pattison D, Wang H, Yoshida M
core   +1 more source

The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients

Frontiers in Aging Neuroscience, 2019
These days, the important role of retinoids in adult brain functionality and homeostasis is well accepted and has been proven by genomic as well as non-genomic mechanisms.
Malena dos Santos Guilherme, Nicolai M. Stoye, Stefan Rose-John, Christoph Garbers, Andreas Fellgiebel, Kristina Endres   +5 more
doaj   +1 more source

The influence of synaptic activity on neuronal health [PDF]

, 2011
According to the theory of neuronal health, neurons exist in a spectrum of states ranging from highly resilient to vulnerable. An unhealthy neuron may be rendered dysfunctional or non-viable by an insult that would ordinarily be non-toxic to a healthy ...
Al-Mubarak, Angelucci, Bessero, Biondi, Biondi, Bordji, Bruno, Chang, Ciavatta, Corredor, Cui, de Calignon, Dick, D’Amelio, Fishbein, Giles E Hardingham, Hardingham, Hardingham, Hardingham, Hardingham, Hedskog, Hoey, Ikonomidou, Isacson, Karen FS Bell, Kong, Lau, Lee, Leveille, Li, Li, Lin, Lipsky, MacAskill, Macaskill, Marcello, Mckenzie, Mennerick, Milnerwood, Mironov, Morimoto, Nikolaev, Nishijima, Okamoto, Olney, Papadia, Papadia, Rintoul, Saha, Saotome, Soriano, Soriano, Soriano, Spalloni, St-Pierre, Sung, Tampellini, Tampellini, Tashiro, Tauskela, Vashishta, Wang, Wareski, Weydt, Xia, Zhang, Zheng   +66 more
core   +1 more source

Alpha-secretase dependent nuclear localization of the amyloid-β precursor protein-binding protein Fe65 promotes DNA repair

Molecular and Cellular Neuroscience, 2023
Fe65 is a brain enriched adaptor protein involved in various cellular processes, including actin cytoskeleton regulation, DNA repair and transcription. A well-studied interacting partner of Fe65 is the transmembrane amyloid-β precursor protein (APP), which can undergo regulated intramembrane proteolysis (RIP). Following β- and γ-secretase-mediated RIP,
Rebecca S, Revol, Niina A, Koistinen, Preeti K, Menon, Almudena, Chicote-Gonzàlez, Kerstin, Iverfeldt, Anna-Lena, Ström   +5 more
openaire   +2 more sources

Measurement of TACE Activity in Extracts from Cultured Cells

Bio-Protocol, 2014
In cigarette smoke–induced and inflammation-associated lung cancer development, cigarette smoke extract (CSE) activates tumor necrosis factor-alpha (TNF-α) secretion from macrophages. TNF-α converting enzyme (TACE), also known as α-Secretase or ADAM17 (A
Xiuling Xu, Mabel Padilla, Yong Lin
doaj   +1 more source

ADAM15 modulates outside-in signalling in chondrocyte–matrix interactions [PDF]

, 2008
ADAM15 belongs to a family of transmembrane multi-domain proteins implicated in proteolysis, cell–cell and cell–matrix interactions in various disease conditions.
Burkhardt, Harald, Böhm, Beate B., Schirner, Andrea   +2 more
core   +1 more source