Results 41 to 50 of about 16,063 (220)
Medicines, 2016 Background: Alzheimer’s disease is one of the most prevalent dementias in the elderly population with increasing numbers of patients. One pivotal hallmark of this disorder is the deposition of protein aggregates stemming from neurotoxic amyloid-beta ...
Myriam Meineck +4 more
doaj +1 more source
Membrane biophysics and mechanics in Alzheimer's disease [PDF]
, 2010 Alzheimer's disease is a chronic neurodegenerative disorder characterized by neuronal loss, cerebrovascular inflammation, and accumulation of senile plaques in the brain parenchyma and cerebral blood vessels. Amyloid-β peptide (Aβ), a major component
Askarova, Sholpan +2 more
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Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure
Advanced Science, 2021 Alzheimer's disease (AD) is a progressive neurodegenerative disease with no cure. Huge efforts have been made to develop anti‐AD drugs in the past decades. However, all drug development programs for disease‐modifying therapies have failed.
Xianwei Chen +9 more
doaj +1 more source
Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease [PDF]
, 2011 We recently reported that expression levels of tumor necrosis factor (TNF) receptors, TNFR1 and TNFR2, are significantly changed in the brains and cerebral spinal cerebral fluid (CSF) with Alzheimer's disease (AD).
Hong Jiang +6 more
core +2 more sources
Medical Sciences, 2018 The present review analyzes the results of recent clinical trials of β secretase inhibition in sporadic Alzheimer’s disease (SAD), considers the striking dichotomy between successes in tests of β-site Amyloid Precursor Protein-Cleaving ...
Vladimir Volloch, Sophia Rits
doaj +1 more source
Human Cord Blood Serum-Derived APP α-Secretase Cleavage Activity is Mediated by C1 Complement
Cell Transplantation, 2018 Alzheimer’s Disease (AD) is the leading cause of dementia in the elderly. In healthy individuals, amyloid precursor protein (APP) is cleaved by α-secretase, generating soluble α-amyloid precursor protein (sAPPα), which contributes neuroprotective ...
Ahsan Habib +9 more
doaj +1 more source
PLoS ONE, 2009 Alzheimer's disease (AD) is the most common cause of dementia among older people. At present, there is no cure for the disease and as of now there are no early diagnostic tests for AD.
Weiping Qin +4 more
doaj +1 more source
Mangiferin: Analgesic properties in neuropathic pain, molecular docking and meta-analysis
Phytomedicine Plus, 2022 Aim: : To investigate the analgesic effects of mangiferin (MAF) in experimental neuropathic pain (NPP) models and underlying mechanism. Methods: : Databases including Pubmed, Web of Science, Embase, Cochrane Library, China national knowledge ...
Bo-tao Chang +8 more
doaj +1 more source
Soluble Alpha-APP (sAPPalpha) Regulates CDK5 Expression and Activity in Neurons [PDF]
, 2013 A growing body of evidence suggests a role for soluble alpha-amyloid precursor protein (sAPPalpha) in pathomechanisms of Alzheimer disease (AD). This cleavage product of APP was identified to have neurotrophic properties.
Hartl, Daniela +6 more
core +6 more sources
Advanced Healthcare Materials, EarlyView.Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim +4 more
wiley +1 more source