Results 51 to 60 of about 16,063 (220)

Rusty microglia: trainers of innate immunity in Alzheimer's disease [PDF]

, 2018
Alzheimer's disease, the most common form of dementia, is marked by progressive cognitive and functional impairment believed to reflect synaptic and neuronal loss.
Adonis Sfera, Adonis Sfera, Amy I. Price, Carolina Osorio, Eddie Diaz, Michael Cummings, Roberto Gradini   +6 more
core   +2 more sources

Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti‐Apoptotic, and Neurotrophic Treatments

Advanced Healthcare Materials, EarlyView.
Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise, Fucen Luo, Borislav Angelov, Yuru Deng, Angelina Angelova   +4 more
wiley   +1 more source

Unveiling neuroprotective mechanisms of diosgenin and pterostilbene in diabetes-associated Alzheimer’s disease through multi-target molecular docking approach [PDF]

Journal of HerbMed Pharmacology
Introduction: Diabetes mellitus (DM) and Alzheimer’s disease (AD) are two highly linked disorders due to their association with the aging population.
Syeda Jabeen Fatima, Devarakonda Krishna Prasad   +1 more
doaj   +1 more source

Notch activates Wnt-4 signalling to control medio-lateral patterning of the pronephros [PDF]

, 2009
Previous studies have highlighted a role for the Notch signalling pathway during pronephrogenesis in the amphibian Xenopus laevis, and in nephron development in the mammalian metanephros, yet a mechanism for this function remains elusive.
Jones, E. A., Naylor, Richard William
core   +1 more source

The Uppsala APP Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo

Advanced Science, EarlyView.
We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Junyue Ge, María Pagnon de la Vega, Silvia Zampar, Enrica Cerilli, Srinivas Koutarapu, Ling Wu, Paul Fraser, Sertan Arkan, Vilmantas Giedraitis, Lars Lannfelt, Greta Hultqvist, Stina Syvänen, Martin Ingelsson, Jörg Hanrieder, Dag Sehlin   +14 more
wiley   +1 more source

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts [PDF]

Human Molecular Genetics, 2002
The metalloprotease ADAM 10 is an important APP alpha-secretase candidate, but in vivo proof of this is lacking. Furthermore, invertebrate models point towards a key role of the ADAM 10 orthologues Kuzbanian and sup-17 in Notch signalling. In the mouse, this function is, however, currently attributed to ADAM 17/TACE, while the role of ADAM 10 remains ...
Hartmann, Dieter, de Strooper, Bart, Serneels, Lutgarde, Craessaerts, Katleen, Herreman, An, Annaert, Wim, Umans, Lieve, Lübke, Torben, Illert, Anna Lena, von Figura, Kurt, Saftig, Paul   +10 more
openaire   +3 more sources

Activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha Facilitates Lymphangiogenesis in Lacrimal Glands in Dry Eye. [PDF]

PLoS ONE, 2016
By using hypoxia-inducible factor-1 alpha conditional knockout (HIF-1α CKO) mice and a dry eye (DE) mouse model, we aimed to determine the role played by delta-like ligand 4 (Dll4)/Notch signaling and HIF-1α in the lymphangiogenesis of lacrimal glands ...
Ji Hwan Min, Chul Hee Lee, Yong Woo Ji, Areum Yeo, Hyemi Noh, Insil Song, Eung Kweon Kim, Hyung Keun Lee   +7 more
doaj   +1 more source

Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design [PDF]

, 2013
β-Secretase (BACE1), the enzyme responsible for the first and rate-limiting step in the production of amyloid-β peptides, is an attractive target for the treatment of Alzheimer’s disease.
A. Peter Johnson, Aoyama T., Baret P., Baxter E. W., Bedford R. B., Besong G. E., Callaway E., Cesar J., Cole D. C., Colin W. G. Fishwick, Coutts R. T., Davies M., Eder J., Eva Casas-Arce, Ghosh A. K., Ghosh A. K., Gillet V. J., Goodyer C. L. M., Guengerich F. P., Hardy J. A., Hong L., Hooper N. M., Huang D. Z., Huang D. Z., Huang W. H., Hussain I., James Chadwick, Ju Y. H., Katherine A. B. Kellett, Law J. M. S., Lin X. L., Mancini F., Mok N. Y., N. Yi Mok, Nigel M. Hooper, Parvathy S., Robichaud J., Selkoe D. J., Serafin B., Sinha S., Sun X. L., Vassar R., Woon E. C. Y., Xu W. J.   +43 more
core   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer’s disease

Frontiers in Aging Neuroscience, 2013
Amyloid β (Aβ) accumulation is considered the main culprit in the pathogenesis of Alzheimer's disease (AD). Recent studies suggest that decreasing Aβ production at very early stages of AD could be a promising strategy to slow down disease progression ...
Patrizia eGiannoni, Patrizia eGiannoni, Patrizia eGiannoni, Florence eGaven, Florence eGaven, Florence eGaven, Dimitri eDe Bundel, Dimitri eDe Bundel, Dimitri eDe Bundel, Kevin eBaranger, Kevin eBaranger, Kevin eBaranger, Evelyne eMarchetti-Gauthier, Evelyne eMarchetti-Gauthier, François S Roman, François S Roman, Emmanuel eValjent, Emmanuel eValjent, Emmanuel eValjent, Philippe eMarin, Philippe eMarin, Philippe eMarin, Joël eBockaert, Joël eBockaert, Joël eBockaert, Santiago eRivera, Santiago eRivera, Santiago eRivera, Sylvie eClaeysen, Sylvie eClaeysen, Sylvie eClaeysen   +30 more
doaj   +1 more source