Results 91 to 100 of about 10,851 (203)

The Effects of Alpha Lipoic Acid on Oxidative Stress, Lipid Profile, and Blood Glucose Levels in Type 2 Diabetic Male Sprague Dawley Rats

Life and Science
Objective: To determine the effect of Alpha Lipoic Acid (ALA) on blood glucose, lipid profile, and oxidative stress in streptozotocin-induced type II diabetic male Sprague Dawley rats. Study Design: Laboratory-based experimental study.
Barkat Ullah Khan, Sidra Arshad, Faiza Ikram, Iftekhar Yousef, Inam Naizi, Muhammad Ismaeel   +5 more
doaj   +1 more source

Rethinking Chronic Wound Treatment: Unlocking the Potential of Combination Products for an Unmet Multifactorial Need: A Review Study

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims Chronic wounds, including diabetic foot, venous, and pressure ulcers, remain a major unmet medical challenge due to their prevalence, severity, and the limited efficacy of current treatments. These wounds are inherently multifactorial, requiring simultaneous intervention across all chronicity‐inducing factors.
Alberto Nicolás Ramos, Nicolás Cerusico, Romina Chavez‐Jara   +2 more
wiley   +1 more source

Dynamic Gelatin Hydrogels Crosslinked by Dithiolane‐Norbornene Click Chemistry

Macromolecular Bioscience, Volume 26, Issue 2, February 2026.
Gelatin‐norbornene (GelNB) and poly(ethylene glycol)‐tetra‐lipoic acid (PEG4LA) are modularly photo‐crosslinked into gelatin‐based hydrogels with dynamically tunable mechanics for expansion and differentiation of induced pluripotent stem cells (iPSC). ABSTRACT Hydrogels prepared from gelatin are ideal for mimicking the extracellular matrix (ECM) owing ...
Favour O. Afolabi, Lydia Yang He, Chien‐Chi Lin   +2 more
wiley   +1 more source

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Hydrogels for Cancer Immunotherapy: Strategies From Construction to Application

MedComm, Volume 7, Issue 2, February 2026.
Hydrogels offer an innovative platform for cancer immunotherapy. Through tailorable crosslinking strategies, they form customizable drug delivery platforms that address diverse therapeutic requirements by loading specific immunotherapeutic agents. These systems demonstrate significant clinical potential for precise tumor immunotherapy.
Xiaohua Chen, Shan Wu, Yueyang Zhang, Lilu Feng, Yang Chen, Xuzhao Yang, Ke Men, Jiuqun Zhu, Ming Li   +8 more
wiley   +1 more source

Combined Analysis of Transcriptome and Metabolome Explains the Differences in Pulp Color in Jackfruit

Plant Direct, Volume 10, Issue 2, February 2026.
ABSTRACT The pulp color of jackfruit reflects variations in its nutritional composition and influences market preference. We investigated the mechanism underlying pulp coloration through an integrated transcriptomic and metabolomic analysis of three jackfruit cultivars—light yellow “THA”, yellow “GTM”, and orange “YNH”.
Jianjun Liang, Xiangwei Ma, Chenxin Yi, Hailan Zhou, Zhuangmin Wei, Xiuguan Tang, Weiyan Ye, Hailing Tang, Pengjin Zhu   +8 more
wiley   +1 more source

Therapeutic potential of thioctic (alpha-lipoic) acid in patients with diabetes mellitus type 2 and metabolic associated fatty liver disease

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Diabetes mellitus type 2 (T2DM) and metabolic associated fatty liver disease (MAFLD) are common metabolic diseases that are often accompanied by obesity, dyslipidemia and hypertension.
Yu.F. Marchuk, V.V. Vivsiannyk, I.I. Alieksieieva, D.R. Andriychuk   +3 more
doaj   +1 more source

Boosting Cuproptosis in Breast Cancer Therapy via Photodynamic Treatment With a New Liposome

FASEB BioAdvances, Volume 8, Issue 2, February 2026.
ABSTRACT Breast cancer (BC) is one of the most common cancers in women around the world, and utilizing a combined approach is a crucial strategy. Induction of cuproptosis in tumor cells is a novel antitumor approach, though its standalone efficacy remains unclear.
Jie Yu, Ning Sun, Limei You, Jialing Liu, Mengna Niu, Jiacheng Shi, Weixin Chen, Futong Li, Shengbao Wang, Jiaqi Liu   +9 more
wiley   +1 more source

The Role of the Gut Microbiome in the Complex Network of Frailty Syndrome and Associated Comorbidities in Aging

Aging Cell, Volume 25, Issue 2, February 2026.
This study analyzed gut microbiota in older adults with and without Frailty Syndrome by 16S rRNA gene sequencing and metagenomics. Frailty was associated with altered microbial composition, metabolic functions, and increased antimicrobial resistance, whereas non‐frail individuals showed healthier profiles.
Ana Barberá, Rosario Ortolá, Mercedes Sotos‐Prieto, Fernando Rodríguez‐Artalejo, Andrés Moya, Susana Ruiz‐Ruiz   +5 more
wiley   +1 more source