Results 91 to 100 of about 17,945 (225)

TIMP‐2 as a Potential Indicator of Persistent Arthralgia in Chikungunya: Evidence From a Brazilian Cohort Study

Journal of Medical Virology, Volume 97, Issue 10, October 2025.
ABSTRACT Chikungunya virus (CHIKV) infection can trigger a sustained inflammatory response, often leading to chronic musculoskeletal pain. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) may contribute to the persistence of arthralgia through their involvement in joint tissue remodeling and degradation. This study aimed to evaluate
Ana Clara Santos Costa, Anderson Felix dos Santos, Gabriela Cavalcanti Lima Albuquerque, Michelle Melgarejo da Rosa, Jamile Taniele‐Silva, Angela Luzia Branco Pinto Duarte, Maira Galdino da Rocha Pitta, André Machado de Siqueira, Amanda Pinheiro de Barros Albuquerque, Moacyr Jesus Barreto de Melo Rego   +9 more
wiley   +1 more source

Mutagenesis of the conserved 51-nucleotide region of Sindbis virus [PDF]

, 1990
We have constructed 25 site-specific mutations in a domain of 51 nucleotides in Sindbis virus that is highly conserved among all alphaviruses sequenced to date.
Niesters, Hubert G. M., Strauss, James H.   +1 more
core  

Promising Cancer Vaccine for Glioblastoma Therapy: A Focus on mRNA Vaccine

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Background Glioblastoma (GBM) is an aggressive primary brain tumor with poor prognosis and low survival rates. Standard treatments, such as surgery and radiotherapy, are limited by tumor infiltration and resistance. To review current vaccine strategies for GBM, including peptide, virotherapy, cell‐based, and genetic vaccines, with a focus on ...
Sama Barati, Sahar Ghoflchi, Pejman Hosseinzadeh, Sobhan Pouramini, Hossein Hosseini, Mohammad Jalili‐Nik   +5 more
wiley   +1 more source

Hunting in the Rainforest and Mayaro Virus Infection: An emerging Alphavirus in Ecuador

Journal of Global Infectious Diseases, 2011
Objectives: The objectives of this report were to document the potential presence of Mayaro virus infection in Ecuador and to examine potential risk factors for Mayaro virus infection among the personnel of a military garrison in the Amazonian rainforest.
Sten H. Vermund, Bolivar Guerra, Maurizio Macaluso, Ligia M Cruz, Robert B. Tesh, Douglas M. Watts, Sagar Galwankar, Ricardo Izurieta   +7 more
openaire   +3 more sources

Semliki Forest viiruse replikaasivalgu nsP1 uurimine [PDF]

, 2013
Väitekirja elektrooniline versioon ei sisalda publikatsioone.Semliki Forest viirus kuulub alfaviiruste perekonda sugukonnas Togaviridae. Alfaviirused on olulised patogeenid ning põhjustavad erinevaid vaevusi nii loomadele kui ka inimestele.
Karo-Astover, Liis
core  

Role of Pentraxin 3 in Shaping Arthritogenic Alphaviral Disease: From Enhanced Viral Replication to Immunomodulation [PDF]

, 2015
10.1371/journal.ppat.1004649PLoS ...
Blanchard, Helen, Chen, Weiqiang, Foo, Suan-Sin, Garlanda, Cecilia, Herrero, Lara J., Mahalingam, Suresh, Mantovani, Alberto, Ng, Fong Poh Lisa, Reading, Patrick C., Sheng, Kuo-Ching, Taylor, Adam, Teng, Terk- Shin, Yu, Xing   +12 more
core   +4 more sources

Human Antibody Responses to Emerging Mayaro Virus and Cocirculating Alphavirus Infections Examined by Using Structural Proteins from Nine New and Old World Lineages

mSphere, 2018
Mayaro virus (MAYV), Venezuelan equine encephalitis virus (VEEV), and chikungunya virus (CHIKV) are vector-borne alphaviruses that cocirculate in South America.
Jessica L. Smith, Christine L. Pugh, Emily D. Cisney, Sarah L. Keasey, Carolina Guevara, Julia S. Ampuero, Guillermo Comach, Doris Gomez, Margarita Ochoa-Diaz, Robert D. Hontz, Robert G. Ulrich   +10 more
doaj   +1 more source

Promising Prodiginins Biological Activities

Chemistry &Biodiversity, Volume 22, Issue 9, September 2025.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto, Melisa E. Gantner, Boris E. Rodenak‐Kladniew, Santiago Rodriguez, María L. Cuestas, Alan Talevi, Guillermo R. Castro   +6 more
wiley   +1 more source

Variable effects ofWolbachiaon alphavirus infection inAedes aegypti

, 2023
2.AbstractWolbachia pipientis(=Wolbachia) has promise as a tool to suppress virus transmission byAedes aegyptimosquitoes. However,Wolbachiacan have variable effects on mosquito-borne viruses. This variation remains poorly characterized, yet the multimodal effects ofWolbachiaon diverse pathogens could have important implications for public health. Here,
Brittany L. Dodson, Sujit Pujhari, Marco Brustolin, Hillery C. Metz, Jason L. Rasgon   +4 more
openaire   +2 more sources

A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs [PDF]

, 2016
Chikungunya virus (CHIKV) is a globally spreading alphavirus against which there is no commercially available vaccine or therapy. Here we use a genome-wide siRNA screen to identify 156 proviral and 41 antiviral host factors affecting CHIKV replication ...
Berre, Stefano, Bracher, Franz, Braun, Peter, Couderc, Thérèsr, Gangneux, Nicolas, Karlas, Alexander, Karo-Astover, Liis, Klemm, Uwe, Lecuit, Marc, Merits, Andres, Meyer, Michael, Meyer, Thomas F., Raftery, Martin, Schönrich, Günther, Varjak, Margus, Weege, Friderike, Wurzlbauer, Anne   +16 more
core   +4 more sources