Results 131 to 140 of about 15,327 (237)

Structure‐Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus‐2 Nsp3 Macrodomain

ChemBioChem, Volume 26, Issue 23, November 27, 2025.
Structure‐guided design of a sulfamoyl‐modified analog of GS‐441524 yielded a selective, high‐affinity inhibitor of the SARS‐CoV‐2 macrodomain Nsp3b. The compound occupies the phosphate‐binding pocket, forming a stabilizing hydrogen‐bond network that enhances binding affinity (K_D = 0.86 μM).
Robin Krishnathas, Konstantin S. Mineev, Nikolaos K. Fourkiotis, Franck Touret, Christos Sideras‐Bisdekis, Aikaterini C. Tsika, Santosh Lakshmi Gande, Verena Linhard, Sridhar Sreeramulu, Frank Lennartz, Manfred S. Weiss, Bruno Coutard, Georgios A. Spyroulias, Harald Schwalbe   +13 more
wiley   +1 more source

Oncolytic Alphaviruses in Cancer Immunotherapy [PDF]

Vaccines, 2017
Oncolytic viruses show specific targeting and killing of tumor cells and therefore provide attractive assets for cancer immunotherapy. In parallel to oncolytic viral vectors based on adenoviruses and herpes simplex viruses, oncolytic RNA viruses and particularly alphaviruses have been evaluated as delivery vehicles. Immunization studies in experimental
openaire   +2 more sources

Host-Driven Ubiquitination Events in Vector-Transmitted RNA Virus Infections as Options for Broad-Spectrum Therapeutic Intervention Strategies

Viruses
Many vector-borne viruses are re-emerging as public health threats, yet our understanding of the virus–host interactions critical for productive infection remains limited. The ubiquitination of proteins, including host- and pathogen-derived proteins is a
Sanskruthi Sreepangi, Haseebullah Baha, Lorreta Aboagyewa Opoku, Naomi X. Jones, Maame Konadu, Farhang Alem, Michael D. Barrera, Aarthi Narayanan   +7 more
doaj   +1 more source

Attenuated Semliki Forest virus for cancer treatment in dogs : safety assessment in two laboratory Beagles [PDF]

, 2015
Background: Dogs suffer from spontaneous tumors which may be amenable to therapies developed for human cancer patients, and dogs may serve as large-animal cancer models.
Anttila, Marjukka O., Autio, Karoliina P. M., Hemminki, Akseli, Hinkkanen, Ari E., Niittykoski, Minna, Ruotsalainen, Janne J., Vähä-Koskela, Markus J. V., Waris, Matti   +7 more
core   +1 more source

Macrophages as target cells for Mayaro virus infection: involvement of reactive oxygen species in the inflammatory response during virus replication

Anais da Academia Brasileira de Ciências
Alphaviruses among the viruses that cause arthritis, consisting in a public health problem worldwide by causing localized outbreaks, as well as large epidemics in humans.
MARIANA G. CAVALHEIRO, LEANDRO SILVA DA COSTA, HOLMES S. CAMPOS, LETÍCIA S. ALVES, IRANAIA ASSUNÇÃO-MIRANDA, ANDREA T. DA POIAN   +5 more
doaj   +1 more source

Experimental Infection of Potential Reservoir Hosts with Venezuelan Equine Encephalitis Virus, Mexico

Emerging Infectious Diseases, 2009
In 1993, an outbreak of encephalitis among 125 affected equids in coastal Chiapas, Mexico, resulted in a 50% case-fatality rate. The outbreak was attributed to Venezuelan equine encephalitis virus (VEEV) subtype IE, not previously associated with equine ...
Eleanor R. Deardorff, Naomi L. Forrester, Amelia P. Travassos da Rosa, Jose G. Estrada-Franco, Roberto Navarro-Lopez, Robert B. Tesh, Nikos Vasilakis   +6 more
doaj   +1 more source

Pseudotyped Lentiviral Vectors: One Vector, Many Guises [PDF]

, 2017
Viruses have evolved specialized molecular mechanisms to transfer their genome efficiently into host cells. Viruses can be repurposed into viral vectors to achieve controlled gene transfer to desired cells.
Joglekar, Alok V., Sandoval, Salemiz
core  

MHC Class II–Alpha Chain Knockout Mice Support Increased Viral Replication That Is Independent of Their Lack of MHC Class II Cell Surface Expression and Associated Immune Function Deficiencies

, 2015
MHCII molecules are heterodimeric cell surface proteins composed of an α and β chain. These molecules are almost exclusively expressed on thymic epithelium and antigen presenting cells (APCs) and play a central role in the development and function of CD4
Alsharifi, Mohammed, Bettadapura, Jayaram, Koskinen, Aulikki, Müllbacher, Arno, Wijesundara, Danushka K.   +4 more
core   +1 more source

SNAP-tagged Chikungunya Virus Replicons Improve Visualisation of Non-Structural Protein 3 by Fluorescence Microscopy [PDF]

, 2017
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes febrile disease, muscle and joint pain, which can become chronic in some individuals. The non-structural protein 3 (nsP3) plays essential roles during infection, but a complete understanding ...
A Gautier, A Ivanova, A Salonen, A Utt, AC Register, AE Firth, B Meason, B Thaa, BM Kummerer, C Li, C Schilte, C Smalley, CB Muller, CJ Sheppard, D Moradpour, D Ross-Thriepland, DY Kim, E Born van den, E Frolova, E Herker, E Park, EI Frolova, F Chaumont de, FE Scholte, FE Scholte, G Camus, G Lukinavicius, G Shi, G Shin, G Yang, GP Li, H Gong, H Malet, H Nakabayashi, H Tourriere, H Vihinen, H Vihinen, H Wang, HJ Yang, I De, I Frolov, IM Cristea, J Peranen, JE Snyder, JH Strauss, JJ Fros, JJ Fros, K Bojkowska, K Onomoto, K Tsetsarkin, KM Dean, L Eckei, L Pohjala, M Eckhardt, M Neuvonen, M Neuvonen, M Ruiz-Guillen, MD Panas, MD Panas, MD Panas, ML Rajamaki, MW LaStarza, N Tamberg, NF Rose, NJ Foy, P Bieling, P Laakkonen, P Targett-Adams, R Abdelnabi, R Gorchakov, RL McPherson, S Martin, S Mueller, SC Weaver, T Ahola, T Fujimoto, T Klein, WR Hardy, Y Fujimoto, Y Miyanari, YF Wang   +80 more
core   +1 more source

The growth of arthralgic Ross River virus is restricted in human monocytic cells [PDF]

, 2016
International audienceAlphaviruses such as Chikungunya and Ross River (RRV) viruses are associated with persistent arthritisand arthralgia in humans. Monocytes and macrophages are believed to play an important role in alphaviralarthritides. In this study,
Belarbi, Essia, Desprès, Philippe, El Kalamouni, Chaker, Gadea, Gilles, Krejbich-Trotot, Pascale, Ralambondrainy, Miora, Roques, Pierre, Viranaicken, Wildriss   +7 more
core   +2 more sources