Results 131 to 140 of about 15,705 (275)

Human Synovial Mesenchymal Stem Cells Expressed Immunoregulatory Factors IDO and TSG6 in a Context of Arthritis Mediated by Alphaviruses [PDF]

, 2023
Melissa Payet, Axelle Septembre‐Malaterre, Philippe Gasque, Xavier Guillot   +3 more
openalex   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, Volume 37, Issue 42, October 23, 2025.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

Alphavirus polymerase and RNA replication [PDF]

, 2017
Alphaviruses are typically arthropod-borne, and many are important pathogens such as chikungunya virus. Alphaviruses encode four nonstructural proteins (nsP1-4), initially produced as a polyprotein P1234. nsP4 is the core RNA-dependent RNA polymerase but
Ahola, Tero, Hellström, Kirsi, Pietilä, Maija   +2 more
core   +1 more source

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil, Josh J. Friesen, Nuthan V. Bathula, Anneke Strumpel, Chia Hao Ho, Ilana Guez, Kristen Y. S. Kong, Andrew J. Varley, Shigeki J. Miyake‐Stoner, Parinaz Aliahmad, Nathaniel S. Wang, Andrew J. Geall, Anna K. Blakney   +12 more
wiley   +1 more source

CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses

Viruses, 2020
Emerging and re-emerging arthritogenic alphaviruses, such as Chikungunya virus (CHIKV) and O’nyong nyong virus, cause acute and chronic crippling arthralgia associated with inflammatory immune responses.
Tao Lin, Tingting Geng, Andrew G. Harrison, Duomeng Yang, A. Vella, E. Fikrig, Penghua Wang   +6 more
semanticscholar   +1 more source

Host-Driven Ubiquitination Events in Vector-Transmitted RNA Virus Infections as Options for Broad-Spectrum Therapeutic Intervention Strategies

Viruses
Many vector-borne viruses are re-emerging as public health threats, yet our understanding of the virus–host interactions critical for productive infection remains limited. The ubiquitination of proteins, including host- and pathogen-derived proteins is a
Sanskruthi Sreepangi, Haseebullah Baha, Lorreta Aboagyewa Opoku, Naomi X. Jones, Maame Konadu, Farhang Alem, Michael D. Barrera, Aarthi Narayanan   +7 more
doaj   +1 more source

Experimental Infection of Potential Reservoir Hosts with Venezuelan Equine Encephalitis Virus, Mexico

Emerging Infectious Diseases, 2009
In 1993, an outbreak of encephalitis among 125 affected equids in coastal Chiapas, Mexico, resulted in a 50% case-fatality rate. The outbreak was attributed to Venezuelan equine encephalitis virus (VEEV) subtype IE, not previously associated with equine ...
Eleanor R. Deardorff, Naomi L. Forrester, Amelia P. Travassos da Rosa, Jose G. Estrada-Franco, Roberto Navarro-Lopez, Robert B. Tesh, Nikos Vasilakis   +6 more
doaj   +1 more source

SNAP-tagged Chikungunya Virus Replicons Improve Visualisation of Non-Structural Protein 3 by Fluorescence Microscopy [PDF]

, 2017
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes febrile disease, muscle and joint pain, which can become chronic in some individuals. The non-structural protein 3 (nsP3) plays essential roles during infection, but a complete understanding ...
A Gautier, A Ivanova, A Salonen, A Utt, AC Register, AE Firth, B Meason, B Thaa, BM Kummerer, C Li, C Schilte, C Smalley, CB Muller, CJ Sheppard, D Moradpour, D Ross-Thriepland, DY Kim, E Born van den, E Frolova, E Herker, E Park, EI Frolova, F Chaumont de, FE Scholte, FE Scholte, G Camus, G Lukinavicius, G Shi, G Shin, G Yang, GP Li, H Gong, H Malet, H Nakabayashi, H Tourriere, H Vihinen, H Vihinen, H Wang, HJ Yang, I De, I Frolov, IM Cristea, J Peranen, JE Snyder, JH Strauss, JJ Fros, JJ Fros, K Bojkowska, K Onomoto, K Tsetsarkin, KM Dean, L Eckei, L Pohjala, M Eckhardt, M Neuvonen, M Neuvonen, M Ruiz-Guillen, MD Panas, MD Panas, MD Panas, ML Rajamaki, MW LaStarza, N Tamberg, NF Rose, NJ Foy, P Bieling, P Laakkonen, P Targett-Adams, R Abdelnabi, R Gorchakov, RL McPherson, S Martin, S Mueller, SC Weaver, T Ahola, T Fujimoto, T Klein, WR Hardy, Y Fujimoto, Y Miyanari, YF Wang   +80 more
core   +1 more source

Macrophages as target cells for Mayaro virus infection: involvement of reactive oxygen species in the inflammatory response during virus replication

Anais da Academia Brasileira de Ciências
Alphaviruses among the viruses that cause arthritis, consisting in a public health problem worldwide by causing localized outbreaks, as well as large epidemics in humans.
MARIANA G. CAVALHEIRO, LEANDRO SILVA DA COSTA, HOLMES S. CAMPOS, LETÍCIA S. ALVES, IRANAIA ASSUNÇÃO-MIRANDA, ANDREA T. DA POIAN   +5 more
doaj   +1 more source

Pseudotyped Lentiviral Vectors: One Vector, Many Guises [PDF]

, 2017
Viruses have evolved specialized molecular mechanisms to transfer their genome efficiently into host cells. Viruses can be repurposed into viral vectors to achieve controlled gene transfer to desired cells.
Joglekar, Alok V., Sandoval, Salemiz
core