Results 141 to 150 of about 15,705 (275)

To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. [PDF]

, 2015
Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle.
Li, Melody MH, MacDonald, Margaret R, Rice, Charles M   +2 more
core   +1 more source

Replicon RNA Viral Vectors as Vaccines

Vaccines, 2016
Single-stranded RNA viruses of both positive and negative polarity have been used as vectors for vaccine development. In this context, alphaviruses, flaviviruses, measles virus and rhabdoviruses have been engineered for expression of surface protein ...
Kenneth Lundstrom
doaj   +1 more source

A high throughput antiviral screening platform for alphaviruses based on Semliki Forest virus expressing eGFP reporter gene

, 2023
Yu-Jia Shi, Jiaqi Li, Hongqing Zhang, Cheng‐Lin Deng, Qin-Xuan Zhu, Bo Zhang, Xiaodan Li   +6 more
openalex   +1 more source

Agua Salud alphavirus defines a novel lineage of insect-specific alphaviruses discovered in the New World

Journal of General Virology, 2019
The genus Alphavirus harbours mostly insect-transmitted viruses that cause severe disease in humans, livestock and wildlife. Thus far, only three alphaviruses with a host range restricted to insects have been found in mosquitoes from the Old World ...
Kyra Hermanns, M. Marklewitz, Florian Zirkel, Gijs J. Overheul, R. Page, Jose R. Loaiza, C. Drosten, R. V. van Rij, S. Junglen   +8 more
semanticscholar   +1 more source

Characterization of the Rubella Virus Nonstructural Protease Domain and Its Cleavage Site [PDF]

, 1996
The region of the rubella virus nonstructural open reading frame that contains the papain-like cysteine protease domain and its cleavage site was expressed with a Sindbis virus vector. Cys-1151 has previously been shown to be required for the activity of
Chen, Jun-Ping, Strauss, James H., Strauss, Ellen G., Frey, Teryl K.   +3 more
core  

Elucidation of the Epitranscriptomic RNA Modification Landscape of Chikungunya Virus

Viruses
The genomes of positive-sense (+) single-stranded RNA (ssRNA) viruses are believed to be subjected to a wide range of RNA modifications. In this study, we focused on the chikungunya virus (CHIKV) as a model (+) ssRNA virus to study the landscape of viral
Belinda Baquero-Pérez, Enrico Bortoletto, Umberto Rosani, Anna Delgado-Tejedor, Rebeca Medina, Eva Maria Novoa, Paola Venier, Juana Díez   +7 more
doaj   +1 more source

MHC Class II–Alpha Chain Knockout Mice Support Increased Viral Replication That Is Independent of Their Lack of MHC Class II Cell Surface Expression and Associated Immune Function Deficiencies

, 2015
MHCII molecules are heterodimeric cell surface proteins composed of an α and β chain. These molecules are almost exclusively expressed on thymic epithelium and antigen presenting cells (APCs) and play a central role in the development and function of CD4
Alsharifi, Mohammed, Bettadapura, Jayaram, Koskinen, Aulikki, Müllbacher, Arno, Wijesundara, Danushka K.   +4 more
core   +1 more source

Global Impact of Mosquito-borne Alphaviruses on Humans: Their Spread and Rehabilitation

, 2023
Neeta Raj Sharma
openalex   +2 more sources

The many ways in which alphaviruses bind to cells.

Trends in immunology, 2023
S. Raju, L. Adams, Michael S. Diamond
semanticscholar   +1 more source

Interferon regulatory factor 1 protects against chikungunya virus-induced immunopathology by restricting infection in muscle cells [PDF]

, 2017
Diamond, Michael S, Nair, Sharmila, Poddar, Subhajit, Shimak, Raeann M   +3 more
core   +2 more sources