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Tropical Arthritogenic Alphaviruses
Reumatología Clínica (English Edition), 2018Tropical alphaviruses have special tropism for bone and joint tissue. Patients can develop chronic rheumatic disorders similar to rheumatoid arthritis and ankylosing spondylitis. The prototype is Chikungunya virus, although other lesser known viruses in our environment such as Sindbis, Ross River, Mayaro, O'nyong nyong and Barmah Forest viruses have ...
Carla-Ruth, Mejía +1 more
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Studies on the morphology of alphaviruses
Virology, 1979Abstract The symmetrical arrangement of subunits in envelope and nucleocapsid of alphaviruses (Sindbis and Semliki Forest) was investigated. The 80 subunits of the envelope display a hexon-penton clustering in a T = 4 icosahedral surface lattice. The glycoprotein projections are located in bundles on the surface of the morphological subunits.
P J, Enzmann, F, Weiland
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Opsonization of alphaviruses in hamsters
Journal of Medical Virology, 1983AbstractImmune elimination of alphaviruses in immunized hamsters appears to involve formation of virus/antibody aggregates which are subsequently cleared from the circulation by cells of the reticuloendothelial system (RES). Virulent strains of Venezuelan (VEE) and Western equine encephalitis (WEE) viruses which were cleared slowly from the circulation
P B, Jahrling +3 more
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Structure and Assembly of Alphaviruses
1982The alphaviruses are enveloped animal viruses that belong to the family of Toga viruses. The molecular biology of this virus group is almost entirely based on studies with two members of this virus group, the Semliki Forest Virus (SFV) and the Sindbis virus.
H, Garoff, C, Kondor-Koch, H, Riedel
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Alphaviruses in cancer immunotherapy
2023Alphaviruses have frequently been engineered for cancer therapy, cancer immunotherapy, and cancer vaccine development. As members of self-replicating RNA viruses, alphaviruses provide high levels of transgene expression through efficient self-amplifying of their RNA genome in host cells.
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Infection of Cells by Alphaviruses
2011It is widely accepted that alphaviruses enter cells by a process involving endocytosis and low-pH-mediated virus membrane-cell membrane fusion. This model and the data supporting it have received extensive and numerous reviews. The major points presented in support of this model are summarized briefly herein.
Dennis T, Brown, Raquel, Hernandez
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Alphaviruses as expression vectors
Current Opinion in Biotechnology, 1997Alphavirus vectors have been used for efficient high-level expression of a variety of topologically different proteins, allowing studies of protein transport, localization and functional activity in a broad range of host cells. Complex transmembrane proteins have been produced in large quantities through the establishment of scale-up technology ...
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1986
To replicate, viruses must deliver their genomes into the cytoplasm of a host cell, entailing the transport of large macromolecular assemblies through one or more membrane barriers. The problem is not a trivial one, in view of the large size and polar nature of the viral components to be delivered and the fact that both the cell and viral components ...
Margaret Kielian, Ari Helenius
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To replicate, viruses must deliver their genomes into the cytoplasm of a host cell, entailing the transport of large macromolecular assemblies through one or more membrane barriers. The problem is not a trivial one, in view of the large size and polar nature of the viral components to be delivered and the fact that both the cell and viral components ...
Margaret Kielian, Ari Helenius
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Molecular Medicine Today, 1999
The ability to genetically engineer animal viruses enables their application to medical research. The development of non-retroviral RNA viruses as vectors to deliver foreign genes for vaccination and gene therapy is particularly interesting, especially the domestication of the alphavirus group. Two papers in this field have recently been published1xTwo-
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The ability to genetically engineer animal viruses enables their application to medical research. The development of non-retroviral RNA viruses as vectors to deliver foreign genes for vaccination and gene therapy is particularly interesting, especially the domestication of the alphavirus group. Two papers in this field have recently been published1xTwo-
openaire +1 more source