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Virus Research, 2004
Alphaviruses are small highly ordered enveloped RNA viruses, which replicate very efficiently in the infected cell. They consist of a nucleocapsid (NC) and a surrounding membrane with glycoproteins. In the NC the positive single stranded RNA genome of the virus is enclosed by a T=4 icosahedral shell of capsid (C) proteins.
Henrik Garoff +2 more
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Alphaviruses are small highly ordered enveloped RNA viruses, which replicate very efficiently in the infected cell. They consist of a nucleocapsid (NC) and a surrounding membrane with glycoproteins. In the NC the positive single stranded RNA genome of the virus is enclosed by a T=4 icosahedral shell of capsid (C) proteins.
Henrik Garoff +2 more
exaly +3 more sources
International Reviews of Immunology, 2004
Many reports have indicated that infection with SV or SFV induces apoptosis both in cultured cells and in the CNS of mice. In general, the ability of virus strains to induce apoptosis correlates with their neurovirulence, although both apoptosis and neurovirulence are age dependent, i.e., resistance increases with age. SV can induce apoptosis simply by
Mei-Ling, Li, Victor, Stollar
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Many reports have indicated that infection with SV or SFV induces apoptosis both in cultured cells and in the CNS of mice. In general, the ability of virus strains to induce apoptosis correlates with their neurovirulence, although both apoptosis and neurovirulence are age dependent, i.e., resistance increases with age. SV can induce apoptosis simply by
Mei-Ling, Li, Victor, Stollar
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Trends in Microbiology, 1995
The icosahedral structures of alphaviruses and of the external shell of the viral nucleocapsid have been defined to very high resolutions, revealing details of the interactions between the glycoproteins to form trimeric spikes and the nucleocapsid.
Strauss, James H. +2 more
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The icosahedral structures of alphaviruses and of the external shell of the viral nucleocapsid have been defined to very high resolutions, revealing details of the interactions between the glycoproteins to form trimeric spikes and the nucleocapsid.
Strauss, James H. +2 more
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2020
Abstract There are 31 registered alphaviruses belonging to the family Togaviridae, 16 of which are known to cause human infection. They are RNA viruses with global geographical distribution and complex transmission cycles, usually between wild or domestic animals and one or more mosquito species; humans are infected by mosquito bites ...
Ann M. Powers +3 more
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Abstract There are 31 registered alphaviruses belonging to the family Togaviridae, 16 of which are known to cause human infection. They are RNA viruses with global geographical distribution and complex transmission cycles, usually between wild or domestic animals and one or more mosquito species; humans are infected by mosquito bites ...
Ann M. Powers +3 more
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Arthritogenic alphaviruses—an overview
Nature Reviews Rheumatology, 2012Mosquito-transmitted alphaviruses causing human rheumatic disease are globally distributed and include chikungunya virus, Ross River virus, Barmah Forest virus, Sindbis virus, o'nyong-nyong virus and Mayaro virus. These viruses cause endemic disease and, occasionally, large epidemics; for instance, the ...
Andreas, Suhrbier +2 more
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Opsonization of alphaviruses in hamsters
Journal of Medical Virology, 1983AbstractImmune elimination of alphaviruses in immunized hamsters appears to involve formation of virus/antibody aggregates which are subsequently cleared from the circulation by cells of the reticuloendothelial system (RES). Virulent strains of Venezuelan (VEE) and Western equine encephalitis (WEE) viruses which were cleared slowly from the circulation
P B, Jahrling +3 more
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Tropical Arthritogenic Alphaviruses
Reumatología Clínica (English Edition), 2018Tropical alphaviruses have special tropism for bone and joint tissue. Patients can develop chronic rheumatic disorders similar to rheumatoid arthritis and ankylosing spondylitis. The prototype is Chikungunya virus, although other lesser known viruses in our environment such as Sindbis, Ross River, Mayaro, O'nyong nyong and Barmah Forest viruses have ...
Carla-Ruth, Mejía +1 more
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Studies on the morphology of alphaviruses
Virology, 1979Abstract The symmetrical arrangement of subunits in envelope and nucleocapsid of alphaviruses (Sindbis and Semliki Forest) was investigated. The 80 subunits of the envelope display a hexon-penton clustering in a T = 4 icosahedral surface lattice. The glycoprotein projections are located in bundles on the surface of the morphological subunits.
P J, Enzmann, F, Weiland
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Structure and Assembly of Alphaviruses
1982The alphaviruses are enveloped animal viruses that belong to the family of Toga viruses. The molecular biology of this virus group is almost entirely based on studies with two members of this virus group, the Semliki Forest Virus (SFV) and the Sindbis virus.
H, Garoff, C, Kondor-Koch, H, Riedel
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