Results 171 to 180 of about 13,213 (215)
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International Reviews of Immunology, 2004
Many reports have indicated that infection with SV or SFV induces apoptosis both in cultured cells and in the CNS of mice. In general, the ability of virus strains to induce apoptosis correlates with their neurovirulence, although both apoptosis and neurovirulence are age dependent, i.e., resistance increases with age. SV can induce apoptosis simply by
Mei-Ling, Li, Victor, Stollar
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Many reports have indicated that infection with SV or SFV induces apoptosis both in cultured cells and in the CNS of mice. In general, the ability of virus strains to induce apoptosis correlates with their neurovirulence, although both apoptosis and neurovirulence are age dependent, i.e., resistance increases with age. SV can induce apoptosis simply by
Mei-Ling, Li, Victor, Stollar
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Trends in Microbiology, 1995
The icosahedral structures of alphaviruses and of the external shell of the viral nucleocapsid have been defined to very high resolutions, revealing details of the interactions between the glycoproteins to form trimeric spikes and the nucleocapsid.
Strauss, James H. +2 more
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The icosahedral structures of alphaviruses and of the external shell of the viral nucleocapsid have been defined to very high resolutions, revealing details of the interactions between the glycoproteins to form trimeric spikes and the nucleocapsid.
Strauss, James H. +2 more
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Virus Research, 2004
Alphaviruses are small highly ordered enveloped RNA viruses, which replicate very efficiently in the infected cell. They consist of a nucleocapsid (NC) and a surrounding membrane with glycoproteins. In the NC the positive single stranded RNA genome of the virus is enclosed by a T=4 icosahedral shell of capsid (C) proteins.
Henrik, Garoff +2 more
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Alphaviruses are small highly ordered enveloped RNA viruses, which replicate very efficiently in the infected cell. They consist of a nucleocapsid (NC) and a surrounding membrane with glycoproteins. In the NC the positive single stranded RNA genome of the virus is enclosed by a T=4 icosahedral shell of capsid (C) proteins.
Henrik, Garoff +2 more
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Opsonization of alphaviruses in hamsters
Journal of Medical Virology, 1983AbstractImmune elimination of alphaviruses in immunized hamsters appears to involve formation of virus/antibody aggregates which are subsequently cleared from the circulation by cells of the reticuloendothelial system (RES). Virulent strains of Venezuelan (VEE) and Western equine encephalitis (WEE) viruses which were cleared slowly from the circulation
P B, Jahrling +3 more
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Alphaviruses in cancer immunotherapy
2023Alphaviruses have frequently been engineered for cancer therapy, cancer immunotherapy, and cancer vaccine development. As members of self-replicating RNA viruses, alphaviruses provide high levels of transgene expression through efficient self-amplifying of their RNA genome in host cells.
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Alphaviruses as expression vectors
Current Opinion in Biotechnology, 1997Alphavirus vectors have been used for efficient high-level expression of a variety of topologically different proteins, allowing studies of protein transport, localization and functional activity in a broad range of host cells. Complex transmembrane proteins have been produced in large quantities through the establishment of scale-up technology ...
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Structure and Assembly of Alphaviruses
1982The alphaviruses are enveloped animal viruses that belong to the family of Toga viruses. The molecular biology of this virus group is almost entirely based on studies with two members of this virus group, the Semliki Forest Virus (SFV) and the Sindbis virus.
H, Garoff, C, Kondor-Koch, H, Riedel
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Infection of Cells by Alphaviruses
2011It is widely accepted that alphaviruses enter cells by a process involving endocytosis and low-pH-mediated virus membrane-cell membrane fusion. This model and the data supporting it have received extensive and numerous reviews. The major points presented in support of this model are summarized briefly herein.
Dennis T, Brown, Raquel, Hernandez
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1986
To replicate, viruses must deliver their genomes into the cytoplasm of a host cell, entailing the transport of large macromolecular assemblies through one or more membrane barriers. The problem is not a trivial one, in view of the large size and polar nature of the viral components to be delivered and the fact that both the cell and viral components ...
Margaret Kielian, Ari Helenius
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To replicate, viruses must deliver their genomes into the cytoplasm of a host cell, entailing the transport of large macromolecular assemblies through one or more membrane barriers. The problem is not a trivial one, in view of the large size and polar nature of the viral components to be delivered and the fact that both the cell and viral components ...
Margaret Kielian, Ari Helenius
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An improved alphaviruses‐specific RT‐qPCR facilitates monitoring and prevention of alphaviruses
Journal of Medical VirologyAbstractMolecular surveillance is vital for monitoring arboviruses, often employing genus‐specific quantitative reverse‐transcription polymerase chain reaction (RT‐qPCR). Despite this, an overlooked chikungunya fever outbreak occurred in Yunnan province, China, in 2019 and false negatives are commonly encountered during alphaviruses screening practice,
Lyu Xie +3 more
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