Results 181 to 190 of about 13,308 (216)
Some of the next articles are maybe not open access.
Alphaviruses in cancer immunotherapy
2023Alphaviruses have frequently been engineered for cancer therapy, cancer immunotherapy, and cancer vaccine development. As members of self-replicating RNA viruses, alphaviruses provide high levels of transgene expression through efficient self-amplifying of their RNA genome in host cells.
openaire +2 more sources
Infection of Cells by Alphaviruses
2011It is widely accepted that alphaviruses enter cells by a process involving endocytosis and low-pH-mediated virus membrane-cell membrane fusion. This model and the data supporting it have received extensive and numerous reviews. The major points presented in support of this model are summarized briefly herein.
Dennis T, Brown, Raquel, Hernandez
openaire +2 more sources
Future Virology, 2011
Alphaviruses are emerging human pathogens that are transmitted by arthropod vectors. Their ability to infect a wide range of vertebrate hosts including humans, equines, birds and rodents has brought about a series of epidemic and epizootic outbreaks worldwide. Their potential to cause a pandemic has spurred the interest of researchers globally, leading
Foo, Suan Sin +7 more
openaire +2 more sources
Alphaviruses are emerging human pathogens that are transmitted by arthropod vectors. Their ability to infect a wide range of vertebrate hosts including humans, equines, birds and rodents has brought about a series of epidemic and epizootic outbreaks worldwide. Their potential to cause a pandemic has spurred the interest of researchers globally, leading
Foo, Suan Sin +7 more
openaire +2 more sources
Alphaviruses as expression vectors
Current Opinion in Biotechnology, 1997Alphavirus vectors have been used for efficient high-level expression of a variety of topologically different proteins, allowing studies of protein transport, localization and functional activity in a broad range of host cells. Complex transmembrane proteins have been produced in large quantities through the establishment of scale-up technology ...
openaire +2 more sources
Molecular Medicine Today, 1999
The ability to genetically engineer animal viruses enables their application to medical research. The development of non-retroviral RNA viruses as vectors to deliver foreign genes for vaccination and gene therapy is particularly interesting, especially the domestication of the alphavirus group. Two papers in this field have recently been published1xTwo-
openaire +1 more source
The ability to genetically engineer animal viruses enables their application to medical research. The development of non-retroviral RNA viruses as vectors to deliver foreign genes for vaccination and gene therapy is particularly interesting, especially the domestication of the alphavirus group. Two papers in this field have recently been published1xTwo-
openaire +1 more source
1986
To replicate, viruses must deliver their genomes into the cytoplasm of a host cell, entailing the transport of large macromolecular assemblies through one or more membrane barriers. The problem is not a trivial one, in view of the large size and polar nature of the viral components to be delivered and the fact that both the cell and viral components ...
Margaret Kielian, Ari Helenius
openaire +1 more source
To replicate, viruses must deliver their genomes into the cytoplasm of a host cell, entailing the transport of large macromolecular assemblies through one or more membrane barriers. The problem is not a trivial one, in view of the large size and polar nature of the viral components to be delivered and the fact that both the cell and viral components ...
Margaret Kielian, Ari Helenius
openaire +1 more source
VLDLR and ApoER2 are receptors for multiple alphaviruses
Nature, 2021Lars E Clark, Sarah A Clark, Chieyu Lin
exaly
The life cycle of the alphaviruses: From an antiviral perspective
Antiviral Research, 2023Andrew M Skidmore, Steven B Bradfute
exaly