Results 1 to 10 of about 4,783,235 (236)

Confirmation and Characterization of the First Case of Acetolactate Synthase (ALS)-Inhibitor—Resistant Wild Buckwheat (Polygonum convolvulus L.) in the United States

Agronomy, 2020
Wild buckwheat (Polygonum convolvulus L.) is a problem weed and ALS-inhibitors (e.g., chlorsulfuron) are commonly used for its management. Recently, a population of wild buckwheat (KSW-R) uncontrolled with ALS-inhibitors was found in a wheat field in ...
Balaji Aravindhan Pandian, Abigail Friesen, Martin Laforest, Dallas E. Peterson, P. V. Vara Prasad, Mithila Jugulam   +5 more
doaj   +2 more sources

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

Nature Communications, 2018
Amyotrophic lateral sclerosis (ALS) is a neurological disease that leads to loss of voluntary muscle movement. Here, the authors screen for molecules that disrupt interaction between SOD1, a protein linked to ALS, and Derlin-1, and find an inhibitor that
Naomi Tsuburaya, Kengo Homma, Tsunehiko Higuchi, Andrii Balia, Hiroyuki Yamakoshi, Norio Shibata, Seiichi Nakamura, Hidehiko Nakagawa, Shin-ichi Ikeda, Naoki Umezawa, Nobuki Kato, Satoshi Yokoshima, Masatoshi Shibuya, Manabu Shimonishi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Isao Naguro, Keiko Imamura, Haruhisa Inoue, Takao Fujisawa, Hidenori Ichijo   +21 more
doaj   +2 more sources

Model for metabolic resistance against ALS inhibitors

Julius-Kühn-Archiv, 2014
Due to herbicide selection pressure metabolic resistance has evolved in many weed species. In this paper we analyse the interaction between the branched chain amino acid (BBC) pathway and detoxifying pathways for herbicide breakdown.
Richter, Otto, Langemann, Dirk, Beffa, Roland   +2 more
doaj   +2 more sources

ROCK-ALS: Protocol for a Randomized, Placebo-Controlled, Double-Blind Phase IIa Trial of Safety, Tolerability and Efficacy of the Rho Kinase (ROCK) Inhibitor Fasudil in Amyotrophic Lateral Sclerosis

Frontiers in Neurology, 2019
Objectives: Disease-modifying therapies for amyotrophic lateral sclerosis (ALS) are still not satisfactory. The Rho kinase (ROCK) inhibitor fasudil has demonstrated beneficial effects in cell culture and animal models of ALS.
Paul Lingor, Paul Lingor, Markus Weber, William Camu, Tim Friede, Reinhard Hilgers, Andreas Leha, Christoph Neuwirth, René Günther, René Günther, Michael Benatar, Magdalena Kuzma-Kozakiewicz, Helen Bidner, Christiane Blankenstein, Roberto Frontini, Albert Ludolph, Jan C. Koch, The ROCK-ALS Investigators, Shahram Attarian, Mathias Bähr, Matthias Boentert, Nathalie Braun, Philippe Corcia, Isabell Cordts, Marcus Deschauer, Thorsten Grehl, Julian Grosskreutz, Andreas Hermann, Josua Kuttler, Teresa Lengenfeldt, Fabian Maass, Thomas Meyer, Susanne Petri, Yvonne Remane, Jens Schmidt, Joachim Schuster, Marie-Hélène Soriani, Jeffrey Statland, Jochen Weishaupt, Daniel Zeller, Eirini Zielke   +40 more
doaj   +2 more sources

Herbicide resistance prediction: a mechanistic model vs a random forest model

Julius-Kühn-Archiv, 2022
Herbicide Resistance is a major issue in weed control. Prediction tools can help to detect herbicide resistance development in early stages and enable farmers to take countermeasures. These tools can be simulation models combining population dynamics and
Lepke, Janine, Herrmann, Johannes, Beffa, Roland, Richter, Otto   +3 more
doaj   +1 more source

Potential Therapeutic Role of HDAC Inhibitors in FUS-ALS [PDF]

Frontiers in Molecular Neuroscience, 2021
Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). However, the exact pathogenic mechanism of mutant fused in sarcoma (FUS) protein is not completely understood. FUS is an RNA binding protein (RBP) localized predominantly in the nucleus, but ALS-linked FUS mutations can affect its nuclear localization signal impairing its import ...
Clara Tejido, Donya Pakravan, Donya Pakravan, Ludo Van Den Bosch, Ludo Van Den Bosch   +4 more
openaire   +3 more sources

ALS gene overexpression and enhanced metabolism conferring Digitaria sanguinalis resistance to nicosulfuron in China

Frontiers in Plant Science, 2023
Crabgrass (Digitaria sanguinalis) is a common malignant weed in corn fields in China. Recently, the acetolactate synthase (ALS) inhibitor, nicosulfuron, has shown decreasing efficacy against crabgrass.
Ruolin Wang, Ying Sun, Ying Sun, Yuning Lan, Shouhui Wei, Hongjuan Huang, Xiangju Li, Zhaofeng Huang   +7 more
doaj   +1 more source

The effect of neprilysin and renin inhibition on the renal dysfunction following ischemia‐reperfusion injury in the rat

Physiological Reports, 2021
The natriuretic peptide (NP) system counter‐regulates the renin‐angiotensin system (RAS), so enhancing the activity of natriuretic peptides (NPs) may be beneficial in conditions when RAS is activated such as ischemia‐reperfusion injury (IRI).
Fayez T. Hammad, Suhail Al‐Salam, Sarah S. AlZaabi, Maryam M. Alfalasi, Awwab F. Hammad, Javed Yasin, Loay Lubbad   +6 more
doaj   +1 more source

Herbicide Resistance Status of Italian Ryegrass (Lolium multiflorum Lam.) and Alternative Herbicide Options for Its Effective Control in the Huang-Huai-Hai Plain of China

Agronomy, 2022
Italian ryegrass (Lolium multiflorum Lam.) was introduced into China as a kind of turfgrass and has invaded wheat fields of the Huang-Huai-Hai Plain, causing great losses to grain yield.
Wei Li, Cuixia Wu, Mali Wang, Minghao Jiang, Jingxu Zhang, Min Liao, Haiqun Cao, Ning Zhao   +7 more
doaj   +1 more source

Dosis-Wirkungs-Versuche mit Apera spica-venti (L.) in Mecklenburg-Vorpommern

Julius-Kühn-Archiv, 2020
Der Gemeine Windhalm Apera spica-venti (L.) hat sich in den zurückliegenden Jahrzehnten zu einem der wichtigsten Ungräser in Europa entwickelt. Europaweit sind für Windhalm jedoch zunehmende Resistenzfälle besonders gegenüber Herbiziden aus der Gruppe ...
Andert, Sabine, De Mol, Friederike, Jochmann, Jan, Gerowitt, Bärbel   +3 more
doaj   +1 more source