Results 31 to 40 of about 4,783,354 (355)

c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis.

PLoS ONE, 2012
BackgroundAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive death of motor neurons. Although the pathogenesis of ALS remains unclear, several cellular processes are known to be involved, including ...
Ryu Katsumata, Shinsuke Ishigaki, Masahisa Katsuno, Kaori Kawai, Jun Sone, Zhe Huang, Hiroaki Adachi, Fumiaki Tanaka, Fumihiko Urano, Gen Sobue   +9 more
doaj   +1 more source

Vergleich dreier Ringversuche zur radioimmunologischen Thyrotropin-Bestimmung nach dem "Münchner Modell" [PDF]

, 1983
Peer ...
Habermann, J., König, A., Marschner, I., Scriba, Peter Christian, van Thiel, D., Wood, W. G.   +5 more
core   +2 more sources

A Phase 1 study of GDC‐0134, a dual leucine zipper kinase inhibitor, in ALS

Annals of Clinical and Translational Neurology, 2022
Dual leucine zipper kinase (DLK), which regulates the c‐Jun N‐terminal kinase pathway involved in axon degeneration and apoptosis following neuronal injury, is a potential therapeutic target in amyotrophic lateral sclerosis (ALS).
J. Katz, J. Rothstein, M. Cudkowicz, A. Genge, Bjorn Oskarsson, A. B. Hains, Chen Chen, J. Galanter, Braydon L. Burgess, W. Cho, G. Kerchner, Felix L. Yeh, A. Ghosh, S. Cheeti, Logan Brooks, L. Honigberg, Jessica A. Couch, M. Rothenberg, F. Brunstein, K. Sharma, L. H. van den Berg, J. Berry, J. Glass   +22 more
semanticscholar   +1 more source

Compassionate Use of the ROCK Inhibitor Fasudil in Three Patients With Amyotrophic Lateral Sclerosis

Frontiers in Neurology, 2020
The Rho kinase (ROCK) inhibitor Fasudil is a promising drug for a disease-modifying therapy of amyotrophic lateral sclerosis (ALS). In preclinical models, Fasudil was shown to increase motor neuron survival, inhibit axonal degeneration, enhance axonal ...
Jan C. Koch, Josua Kuttler, Fabian Maass, Teresa Lengenfeld, Eirini Zielke, Mathias Bähr, Paul Lingor, Paul Lingor   +7 more
doaj   +1 more source

Solving Sudoku with Membrane Computing [PDF]

, 2010
Sudoku is a very popular puzzle which consists on placing several numbers in a squared grid according to some simple rules. In this paper we present an efficient family of P systems which solve sudokus of any order verifying a specific property.
Díaz Pernil, Daniel, Fernández Márquez, Carlos M., García Quismondo, Manuel, Gutiérrez Naranjo, Miguel Ángel, Martínez del Amor, Miguel Ángel   +4 more
core   +1 more source

Novel chemical inhibitor against SOD1 misfolding and aggregation protects neuron-loss and ameliorates disease symptoms in ALS mouse model

Communications Biology, 2021
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective death of motor neurons. Mutations in Cu, Zn-superoxide dismutase (SOD1) causing the gain of its toxic property are the major culprit of familial ALS (fALS)
Tae-Gyun Woo, Min-Ho Yoon, So-mi Kang, Soyoung Park, Jung-Hyun Cho, Young jun Hwang, Jinsook Ahn, Hyewon Jang, Yun-jeong Shin, E. Jung, N. Ha, B. Kim, Yonghoon Kwon, Bum-Joon Park   +13 more
semanticscholar   +1 more source

CXCR2 increases in ALS cortical neurons and its inhibition prevents motor neuron degeneration in vitro and improves neuromuscular function in SOD1G93A mice

Neurobiology of Disease, 2021
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease characterized by depletion of motor neurons (MNs), for which effective medical treatments are still required.
Valentina La Cognata, Elisabetta Golini, Rosario Iemmolo, Sara Balletta, Giovanna Morello, Carla De Rosa, Ambra Villari, Sara Marinelli, Valentina Vacca, Gabriele Bonaventura, Paola Dell'Albani, Eleonora Aronica, Fabio Mammano, Silvia Mandillo, Sebastiano Cavallaro   +14 more
doaj   +1 more source

Peroxynitrite activates the NLRP3 inflammasome cascade in SOD1(G93A) mouse model of amyotrophic lateral sclerosis [PDF]

, 2017
Neuroinflammation, characterized by the appearance of reactive microglial and astroglial cells, is one of the several pathogenic mechanisms of amyotrophic lateral sclerosis (ALS), a fast-progressing and fatal neurodegenerative disease.
Adamo, Sergio, Bellezza, Ilaria, Costanzi, Egidia, Grottelli, Silvia, Mezzasoma, Letizia, Minelli, Alba, Moresi, Viviana, Morozzi, Giulio, Peirce, Matthew J., Pigna, Eva, Scarpelli, Paolo   +10 more
core   +1 more source

Investigation of ammonium–lauric salt as shale swelling inhibitor and a mechanism study

Adsorption Science & Technology, 2019
In this work, a series of ammonium–lauric salts (ALS) was prepared with lauric acid and amines as small molecular shale swelling inhibitor. The inhibitors were screened by the linear expansion test first, and the result shows that the inhibitor prepared ...
Jie Zhang, Weimin Hu, Li Zhang, Tiehu Li, Dan Cai, Gang Chen   +5 more
doaj   +1 more source

Edaravone: A new hope for patients with amyotrophic lateral sclerosis

Apollo Medicine, 2019
Although the exact pathophysiology of amyotrophic lateral sclerosis (ALS) remains unclear, oxidative stress is known to play a pivotal role. There is no cure for ALS, but there are two drugs available to slow the progression of the disease. Till recently,
Shivangi Garg, Dinesh Chaudhari, Pushpendra Nath Renjen, Anjali Mishra, Abhas Kumar, Rajendra Pradhan   +5 more
doaj   +1 more source