Results 71 to 80 of about 4,783,354 (355)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Diapocynin and apocynin administration fails to significantly extend survival in G93A SOD1 ALS mice

Neurobiology of Disease, 2012
NADPH oxidase has recently been identified as a promising new therapeutic target in ALS. Genetic deletion of NADPH oxidase (Nox2) in the transgenic SOD1G93A mutant mouse model of ALS was reported to increase survival remarkably by 97 days.
Kari A. Trumbull, Donna McAllister, Mandi M. Gandelman, Whitney Y. Fung, Thomas Lew, Lucy Brennan, Nathan Lopez, Jeff Morré, Balaraman Kalyanaraman, Joseph S. Beckman   +9 more
doaj   +1 more source

Elevated peripheral levels of receptor-interacting protein kinase 1 (RIPK1) and IL-8 as biomarkers of human amyotrophic lateral sclerosis

Signal Transduction and Targeted Therapy, 2023
Amyotrophic lateral sclerosis (ALS) is a devastating fatal neurodegenerative disease with no cure. Receptor-interacting protein kinase 1 (RIPK1) has been proposed to mediate pathogenesis of ALS.
Jun Wei, Min Li, Zhi Ye, Xinqian Hu, Xiaoyan He, Jia Wang, Gaofeng Chen, Chengyu Zou, Daichao Xu, Hongbing Zhang, Junying Yuan, Yunhong Zha   +11 more
doaj   +1 more source

Ca2+-activated K+ channels modulate microglia affecting motor neuron survivalin hSOD1G93A mice [PDF]

, 2018
Recent studies described a critical role for microglia in amyotrophic lateral sclerosis (ALS), where these CNS-resident immune cells participate in the establishment of an inflammatory microenvironment that contributes to motor neuron degeneration ...
Antonangeli, Fabrizio, Carbonari, Laura, Cocozza, Germana, D'Alessandro, Giuseppina, di Castro, Maria Amalia, Garofalo, Stefano, Grassi, Francesca, Grimaldi, Alfonso, Limatola, Cristina, Madonna, Michele, Mainiero, Fabrizio, Porzia, Alessandra, Santoni, Angela, Wulff, Heike   +13 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Uncoupling of p97 ATPase activity has a dominant negative effect on protein extraction [PDF]

, 2019
p97 is a highly abundant, homohexameric AAA+ ATPase that performs a variety of essential cellular functions. Characterized as a ubiquitin-selective chaperone, p97 recognizes proteins conjugated to K48-linked polyubiquitin chains and promotes their ...
Long, David T., Rycenga, Halley B., Wolfe, Kelly B., Yeh, Elizabeth S.   +3 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Manejo de Bidens subalternans resistente aos herbicidas inibidores da acetolactato sintase Management of Bidens subalternans resistant to acetolactate synthase inhibitor herbicides

Planta Daninha, 2003
A extensão das áreas com seleção de populações de plantas daninhas resistentes a herbicidas tem aumentado rapidamente no Brasil nos últimos anos, sendo citado como causa principal desta seleção a recomendação inadequada de produtos.
D.L.P. Gazziero, C.E.C. Prete, M. Sumiya
doaj   +1 more source

Cystatin C: a candidate biomarker for amyotrophic lateral sclerosis. [PDF]

PLoS ONE, 2010
Amyotrophic lateral sclerosis (ALS) is a fatal neurologic disease characterized by progressive motor neuron degeneration. Clinical disease management is hindered by both a lengthy diagnostic process and the absence of effective treatments.
Meghan E Wilson, Imene Boumaza, David Lacomis, Robert Bowser   +3 more
doaj   +1 more source

PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage [PDF]

, 2013
Amyotrophic lateral sclerosis (ALS) is associated with progressive degeneration of motor neurons. Several of the genes associated with this disease encode proteins involved in RNA processing, including fused-in-sarcoma/translocated-in-sarcoma (FUS/TLS ...
Adamson, Ahel, Amy Rotheray, Amé, Beli, Bertolotti, Chou, Da Cruz, Das, Dormann, Dormann, Duncan A. Q. Moore, El-Khamisy, Fernando Gómez-Herreros, Gabrielle J. Grundy, Gagné, Gardiner, Gitler, Hallier, Hanson, Hicks, Hoell, Johansson, Keith W Caldecott, Kino, Kleiman, Kleiman, Kleiman, Krietsch, Kuroda, Kwiatkowski, Lagier-Tourenne, Lagier-Tourenne, Lehtiö, Mackenzie, Majid Hafezparast, Malanga, Mastrocola, Masutani, Polo, Polymenidou, Rulten, Rulten, Ryan L. Green, Schwartz, Shieh, Stuart L. Rulten, Tan, Tan, Turner, Vance, Wang, Yang, Yang   +53 more
core   +1 more source