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Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway [PDF]

Frontiers in Immunology, 2021
The complement system is central to first-line defense against invading pathogens. However, excessive complement activation and/or the loss of complement regulation contributes to the development of autoimmune diseases, systemic inflammation, and ...
Jonathan Barratt, Jonathan Barratt, Ilene Weitz   +2 more
doaj   +3 more sources

Alternative Complement Pathway Inhibition Abrogates Pneumococcal Opsonophagocytosis in Vaccine-Naïve, but Not in Vaccinated Individuals [PDF]

Frontiers in Immunology, 2021
To assess the relative contribution of opsonisation by antibodies, classical and alternative complement pathways to pneumococcal phagocytosis, we analyzed killing of pneumococci by human blood leukocytes collected from vaccine-naïve and PCV13-vaccinated ...
Lukas Muri, Lukas Muri, Emma Ispasanie, Emma Ispasanie, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke, Gerd Pluschke   +10 more
doaj   +3 more sources

Low molecular weight polysialic acid binds to properdin and reduces the activity of the alternative complement pathway [PDF]

Scientific Reports, 2022
Sialic acids as the terminal caps of the cellular glycocalyx play an essential role in self-recognition and were shown to modulate complement processes via interaction between α2,3-linked sialic acids and complement factor H. Previously, it was suggested
Anahita Shahraz, Yuchen Lin, Joshua Mbroh, Jonas Winkler, Huan Liao, Marie Lackmann, Annemarie Bungartz, Peter F. Zipfel, Christine Skerka, Harald Neumann   +9 more
doaj   +4 more sources

Low-molecular weight inhibitors of the alternative complement pathway. [PDF]

Immunol Rev, 2023
Dysregulation of the alternative complement pathway predisposes individuals to a number of diseases. It can either be evoked by genetic alterations in or by stabilizing antibodies to important pathway components and typically leads to severe diseases ...
Schubart A, Flohr S, Junt T, Eder J.
europepmc   +2 more sources

COVID-19 microthrombosis: unusually large VWF multimers are a platform for activation of the alternative complement pathway under cytokine storm. [PDF]

Int J Hematol, 2022
ADAMTS13, a metalloproteinase, specifically cleaves unusually large multimers of von Willebrand factor (VWF), newly released from vascular endothelial cells.
Fujimura Y, Holland LZ.
europepmc   +2 more sources

Alternative Complement Pathway Is Activated and Associated with Galactose-Deficient IgA₁ Antibody in IgA Nephropathy Patients. [PDF]

Front Immunol, 2021
Background Galactose-deficient IgA1 (Gd-IgA1) and alternative complement pathway activation are considered to be involved in the pathogenesis of IgA nephropathy (IgAN).
Chiu YL, Lin WC, Shu KH, Fang YW, Chang FC, Chou YH, Wu CF, Chiang WC, Lin SL, Chen YM, Wu MS.   +10 more
europepmc   +2 more sources

Increased Alternative Complement Pathway Function and Improved Survival during Critical Illness. [PDF]

Am J Respir Crit Care Med, 2020
Rationale: Complement is crucial for host defense but may also drive dysregulated inflammation. There is limited understanding of alternative complement function, which can amplify all complement activity, during critical illness. Objectives: We examined
Bain W, Li H, van der Geest R, Moore SR, Olonisakin TF, Ahn B, Papke E, Moghbeli K, DeSensi R, Rapport S, Saul M, Hulver M, Xiong Z, Mallampalli RK, Ray P, Morris A, Ma L, Doi Y, Zhang Y, Kitsios GD, Kulkarni HS, McVerry BJ, Ferreira VP, Nouraie M, Lee JS.   +24 more
europepmc   +2 more sources

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition. [PDF]

Blood, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious respiratory virus that can lead to venous/arterial thrombosis, stroke, renal failure, myocardial infarction, thrombocytopenia, and other end-organ damage.
Yu J, Yuan X, Chen H, Chaturvedi S, Braunstein EM, Brodsky RA.   +5 more
europepmc   +2 more sources

Looking back on the alternative complement pathway. [PDF]

Immunobiology, 2018
The alternative pathway of complement originated from the Properdin pathway originally described by the Pillemer laboratory in the 1950s. This work generated great controversy and it took several decades for a consensus on its components, its reaction sequence and its functions to emerge.
P. Lachmann
semanticscholar   +3 more sources

Alternative Complement Pathway Inhibition by Lampalizumab: Analysis of Data From Chroma and Spectri Phase III Clinical Trials. [PDF]

Ophthalmol Sci, 2023
Purpose: Lampalizumab, an antigen-binding fragment of a humanized monoclonal antibody directed against complement factor D (CFD), is designed to treat geographic atrophy (GA) secondary to age-related macular degeneration. Given the lack of clinical efficacy observed in patients with GA in the phase III Chroma/Spectri trials, we investigated the impact ...
Edmonds R, Steffen V, Honigberg LA, Chang MC.   +3 more
europepmc   +3 more sources