Results 21 to 30 of about 382,720 (316)
Maternal and fetal alternative complement pathway activation in early severe preeclampsia. [PDF]
Am J Reprod Immunol, 2014 We sought to determine whether alternative complement activation fragment Bb (Bb) levels are elevated in the maternal, fetal, and placental blood in cases of severe preeclampsia (PE) compared with normotensive controls.
Hoffman MC +4 more
europepmc +2 more sources
The classical pathway triggers pathogenic complement activation in membranous nephropathy
Nature Communications, 2023 It is generally thought that complement activation in human membranous nephropathy (MN) occurs predominantly via the lectin or alternative pathway. Here, the authors show that the classical pathway is the dominant form of complement activation in MN and ...
Larissa Seifert +23 more
doaj +2 more sources
Blockade of Alternative Complement Pathway in Dense Deposit Disease [PDF]
Case Reports in Nephrology, 2014 A patient aged 17 with dense deposit disease associated with complement activation, circulating C3 Nef, and Factor H mutation presented with nephrotic syndrome and hypertension.
Aurore Berthe-Aucejo +6 more
doaj +2 more sources
The alternative complement pathway regulates pathological angiogenesis in the retina.
FASEB J, 2014 A defining feature in proliferative retinopathies is the formation of pathological neovessels. In these diseases, the balance between neovessel formation and regression determines blindness, making the modulation of neovessel growth highly desirable. The
Sweigard JH +8 more
europepmc +2 more sources
Complement factor D is linked to platelet activation in human and rodent sepsis
Intensive Care Medicine Experimental, 2021 Background The complement factor D (CFD) exerts a regulatory role during infection. However, its physiological function in coagulopathy and its impact on the course of an infection remains unclear. Materials Wild-type and CFD-deficient mice (n = 91) were
O. Sommerfeld +6 more
doaj +1 more source
Frontiers in Immunology, 2021 The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
Wen Q. Qiu +7 more
doaj +1 more source
The intersection of complemented submodules is not complemented [PDF]
J. Math. Anal. Appl. 522 (1) (2023) 127002, 2023 We show by (counter)example that the intersection of complemented submodules in a Hilbert $C^*$-module is not necessarily complemented, answering an open question from [MR].
arxiv +1 more source
The Complement System and ANCA Associated Vasculitis in the Era of Anti-Complement Drugs
Frontiers in Immunology, 2022 ANCA (anti-neutrophil cytoplasmic antibody)-associated vasculitis (AAV) is the condition in which ANCA, as an autoantibody, is associated with the pathogenesis of vasculitis in small blood vessels, mainly in the ear, nose, throat, kidney, lung, and ...
Yasutaka Kimoto, Takahiko Horiuchi
doaj +1 more source
Clinical and Experimental Immunology, 2020 We compared the common pathway components C3a, C5a and membrane attack complex (MAC), also known as C5b‐9, and the alternative pathway components factor B and properdin in patients with ANCA‐associated vasculitis (AAV) and healthy controls, and conducted
S. Moiseev +10 more
semanticscholar +1 more source
Complement alternative pathway activation in human nonalcoholic steatohepatitis. [PDF]
PLoS ONE, 2014 The innate immune system plays a major role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Recently we reported complement activation in human NASH.
Filip M Segers +9 more
doaj +1 more source