Platelets are activated in ANCA-associated vasculitis via thrombin-PARs pathway and can activate the alternative complement pathway. [PDF]
Arthritis Res Ther, 2017 BackgroundIn this study, we investigated the mechanism of platelet activation in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), as well as the activation of the alternative complement pathway by platelets in AAV ...
Miao D, Li DY, Chen M, Zhao MH.
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Frontiers in Immunology, 2018 The complement system has moved into the focus of drug development efforts in the last decade, since its inappropriate or uncontrolled activation has been recognized in many diseases.
József Dobó +2 more
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Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and disease. [PDF]
PLoS Computational Biology, 2020 The complement system is a powerful mechanism of innate immunity poised to eliminate foreign cells and pathogens. It is an intricate network of >35 proteins, which, once activated, leads to the tagging of the surface to be eliminated, produces potent ...
Antonello Caruso +3 more
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Regulation of C3 Activation by the Alternative Complement Pathway in the Mouse Retina. [PDF]
PLoS One, 2016 The purpose of this study was to examine the retinas of mice carrying hemizygous and null double deletions of Cfb-/- and Cfh-/-, and to compare these with the single knockouts of Cfb, Cfh and Cfd. Retinas were isolated from wild type (WT), Cfb-/-/Cfh-/-,
Williams JA +5 more
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Blockade of Alternative Complement Pathway in Dense Deposit Disease [PDF]
Case Reports in Nephrology, 2014 A patient aged 17 with dense deposit disease associated with complement activation, circulating C3 Nef, and Factor H mutation presented with nephrotic syndrome and hypertension.
Aurore Berthe-Aucejo +6 more
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Preanalytical classical and alternative complement pathway activity loss. [PDF]
Biochem Med (Zagreb), 2019 Introduction: Complement functional analyses provide insight into the integrity of the entire complement reaction cascade. These tests are suitable for investigating suspected complement deficiencies.
Vercauteren KOA +2 more
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Changes in extracellular matrix cause RPE cells to make basal deposits and activate the alternative complement pathway. [PDF]
Hum Mol Genet, 2018 Fernandez-Godino R +2 more
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Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury. [PDF]
Sci Transl Med, 2015 Sweigard JH +14 more
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Complement factor D is linked to platelet activation in human and rodent sepsis
Intensive Care Medicine Experimental, 2021 Background The complement factor D (CFD) exerts a regulatory role during infection. However, its physiological function in coagulopathy and its impact on the course of an infection remains unclear. Materials Wild-type and CFD-deficient mice (n = 91) were
O. Sommerfeld +6 more
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Frontiers in Immunology, 2021 The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
Wen Q. Qiu +7 more
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