Alternative Complement Pathway in Carotid Atherosclerosis: Low Plasma Properdin Levels Associate With Long‐Term Cardiovascular Mortality [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid atherosclerosis and related to adverse outcome in ...
Mieke C. Louwe +20 more
doaj +2 more sources
AMD and the alternative complement pathway: genetics and functional implications. [PDF]
Hum Genomics, 2016 Age-related macular degeneration (AMD) is an ocular neurodegenerative disorder and is the leading cause of legal blindness in Western societies, with a prevalence of up to 8 % over the age of 60, which continues to increase with age. AMD is characterized
Tan PL, Bowes Rickman C, Katsanis N.
europepmc +2 more sources
Platelets are activated in ANCA-associated vasculitis via thrombin-PARs pathway and can activate the alternative complement pathway. [PDF]
Arthritis Res Ther, 2017 BackgroundIn this study, we investigated the mechanism of platelet activation in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), as well as the activation of the alternative complement pathway by platelets in AAV ...
Miao D, Li DY, Chen M, Zhao MH.
europepmc +2 more sources
Regulation of C3 Activation by the Alternative Complement Pathway in the Mouse Retina. [PDF]
PLoS One, 2016 The purpose of this study was to examine the retinas of mice carrying hemizygous and null double deletions of Cfb-/- and Cfh-/-, and to compare these with the single knockouts of Cfb, Cfh and Cfd. Retinas were isolated from wild type (WT), Cfb-/-/Cfh-/-,
Williams JA +5 more
europepmc +4 more sources
Preanalytical classical and alternative complement pathway activity loss. [PDF]
Biochem Med (Zagreb), 2019 Introduction: Complement functional analyses provide insight into the integrity of the entire complement reaction cascade. These tests are suitable for investigating suspected complement deficiencies. Falsely reduced test outcomes may result from preanalytical instabilities of individual complement components.
Vercauteren KOA +2 more
europepmc +3 more sources
Blockade of Alternative Complement Pathway in Dense Deposit Disease [PDF]
Case Reports in Nephrology, 2014 A patient aged 17 with dense deposit disease associated with complement activation, circulating C3 Nef, and Factor H mutation presented with nephrotic syndrome and hypertension.
Aurore Berthe-Aucejo +6 more
doaj +2 more sources
Changes in extracellular matrix cause RPE cells to make basal deposits and activate the alternative complement pathway. [PDF]
Hum Mol Genet, 2018 Fernandez-Godino R +2 more
europepmc +2 more sources
Kidney International, 2023 Targeting the alternative complement pathway is an attractive therapeutic strategy given its role in the pathogenesis of immunoglobulin A nephropathy (IgAN). Iptacopan (LNP023) is an oral, proximal alternative complement inhibitor that specifically binds
Hong Zhang +15 more
semanticscholar +1 more source
Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury. [PDF]
Sci Transl Med, 2015 Sweigard JH +14 more
europepmc +2 more sources
Complement factor D is linked to platelet activation in human and rodent sepsis
Intensive Care Medicine Experimental, 2021 Background The complement factor D (CFD) exerts a regulatory role during infection. However, its physiological function in coagulopathy and its impact on the course of an infection remains unclear. Materials Wild-type and CFD-deficient mice (n = 91) were
O. Sommerfeld +6 more
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