Results 31 to 40 of about 539,466 (329)

The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases

Frontiers in Immunology, 2021
The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
Wen Q. Qiu, Shaopeiwen Luo, Stefanie A. Ma, Priyanka Saminathan, Herman Li, Jenny M. Gunnersen, Harris A. Gelbard, Jennetta W. Hammond   +7 more
doaj   +1 more source

The alternative complement pathway revisited [PDF]

Journal of Cellular and Molecular Medicine, 2008
Introduction Methods to study and modify the alternative pathway Influence of AP amplification on the effect of specific activation of the other initial pathways Properdin Influence of AP in deficiency states Complement in sepsis Concluding remarks AbstractAlternative pathway amplification plays a major role for the final effect of initial specific ...
Harboe, Morten, Mollnes, Tom Eirik
openaire   +2 more sources

Complement Alternative and Mannose-Binding Lectin Pathway Activation Is Associated With COVID-19 Mortality

Frontiers in Immunology, 2021
BackgroundThe SARS-CoV-2 infection triggers excessive immune response resulting in increased levels of pro-inflammatory cytokines, endothelial injury, and intravascular coagulopathy.
Federica Defendi, Corentin Leroy, Corentin Leroy, Olivier Epaulard, Olivier Epaulard, Giovanna Clavarino, Antoine Vilotitch, Marion Le Marechal, Marie-Christine Jacob, Tatiana Raskovalova, Martine Pernollet, Audrey Le Gouellec, Audrey Le Gouellec, Jean-Luc Bosson, Pascal Poignard, Pascal Poignard, Matthieu Roustit, Matthieu Roustit, Nicole Thielens, Chantal Dumestre-Pérard, Chantal Dumestre-Pérard, Jean-Yves Cesbron   +21 more
doaj   +1 more source

The Complement System and ANCA Associated Vasculitis in the Era of Anti-Complement Drugs

Frontiers in Immunology, 2022
ANCA (anti-neutrophil cytoplasmic antibody)-associated vasculitis (AAV) is the condition in which ANCA, as an autoantibody, is associated with the pathogenesis of vasculitis in small blood vessels, mainly in the ear, nose, throat, kidney, lung, and ...
Yasutaka Kimoto, Takahiko Horiuchi
doaj   +1 more source

Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi [PDF]

, 2017
Complement is an important part of innate immunity. The alternative pathway of complement is activated when the main opsonin, C3b coats non-protected surfaces leading to opsonisation, phagocytosis and cell lysis.
A Bhattacharjee, A Richards, Adrian Goldman, AJ McCoy, AO Edwards, B Nagar, BS Blaum, C Hammerschmidt, C Siegel, CA Diebolder, Catherine A. Brissette, D Weismann, DE Isenman, DL Gordon, E Goicoechea de Jorge, E Krissinel, EM Adams, J Esparza-Gordillo, J Hellwage, J Pietikäinen, J Wu, JD Lambris, JH Williams Jr., JJ Caesar, JJ Caesar, JM van den Elsen, JM Weiler, K Brangulis, K Haupt, K Whaley, Kornelia M. Mikula, M Jozsi, M Jozsi, M Jozsi, MC Carroll, MD Winn, MJ Lehtinen, MJ Lehtinen, MJ Walport, MK Pangburn, P Emsley, P Kraiczy, PD Adams, PF Zipfel, PW Dempsey, RB Sim, Robert Kolodziejczyk, S Breitner-Ruddock, S Hyvärinen, S Kühn, S Ram, T Kajander, T Meri, T. Sakari Jokiranta, Taru Meri, Tommi Kotila, TS Jokiranta, Vincent L. G. Postis, W Kabsch   +58 more
core   +8 more sources

Diagnosis of complement alternative pathway disorders [PDF]

Kidney International, 2016
Kidney diseases resulting from abnormal control of the complement alternative pathway include atypical hemolytic uremic syndrome, C3 glomerulonephritis, and dense-deposit disease, as well as atypical postinfectious glomerulonephritis. Although clinically diverse, they all result from loss of surface or fluid-phase complement control, caused by acquired
Angioi A, Fervenza FC, Sethi S, Zhang Y, Smith RJ, Murray D, Van Praet J, Pani A, De Vriese AS   +8 more
openaire   +2 more sources

The alternative complement pathway in ANCA‐associated vasculitis: further evidence and a meta‐analysis

Clinical and Experimental Immunology, 2020
We compared the common pathway components C3a, C5a and membrane attack complex (MAC), also known as C5b‐9, and the alternative pathway components factor B and properdin in patients with ANCA‐associated vasculitis (AAV) and healthy controls, and conducted
S. Moiseev, Jiwon M. Lee, A. Zykova, N. Bulanov, P. Novikov, E. Gitel, M. Bulanova, E. Safonova, J. Shin, A. Kronbichler, D. Jayne   +10 more
semanticscholar   +1 more source

COMPLEMENT-MEDIATED ADIPOCYTE LYSIS BY NEPHRITIC FACTOR SERA [PDF]

, 1993
Recent data indicate a previously unsuspected link between the complement system and adipocyte biology. Murine adipocytes produce key components of the alternative pathway of complement and are able to activate this pathway.
Lachmann, PJ, Mathieson, PW, Oliveria, DB, Peters, DK, Würzner, R   +4 more
core   +1 more source

Be on Target: Strategies of Targeting Alternative and Lectin Pathway Components in Complement-Mediated Diseases

Frontiers in Immunology, 2018
The complement system has moved into the focus of drug development efforts in the last decade, since its inappropriate or uncontrolled activation has been recognized in many diseases.
József Dobó, Andrea Kocsis, Péter Gál   +2 more
doaj   +1 more source

Complement activation and protein adsorption by carbon nanotubes [PDF]

, 2006
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel, Green, Malcolm L. H., Salvador-Morales, Carolina, Sim, Edith, Sim, Robert B., Sloan, Jeremy   +5 more
core   +2 more sources