Results 41 to 50 of about 382,720 (316)

The Factor H protein family: The switchers of the complement alternative pathway

Immunological Reviews, 2022
The factor H (FH) protein family is emerging as a complex network of proteins controlling the fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range of diseases including infectious, inflammatory, autoimmune, and ...
Laura Lucientes-Continente, Bárbara Márquez-Tirado, E. Goicoechea de Jorge   +2 more
semanticscholar   +1 more source

Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration

Science Translational Medicine, 2017
The phase 2 MAHALO clinical trial shows that lampalizumab reduces geographic atrophy secondary to age-related macular degeneration and implicates complement dysregulation in disease pathogenesis.
B. Yaspan, David F. Williams, F. Holz, C. Regillo, Zhengrong Li, A. Dressen, M. van Lookeren Campagne, K. Le, R. Graham, Tatiana Beres, T. Bhangale, L. Honigberg, Ashley M. Smith, E. Henry, C. Ho, E. Strauss   +15 more
semanticscholar   +1 more source

Complement Activation via the Lectin and Alternative Pathway in Patients With Severe COVID-19

Frontiers in Immunology, 2022
Complement plays an important role in the direct defense to pathogens, but can also activate immune cells and the release of pro-inflammatory cytokines. However, in critically ill patients with COVID-19 the immune system is inadequately activated leading
Janina Niederreiter, C. Eck, Tajana Ries, A. Hartmann, B. Märkl, M. Büttner-Herold, K. Amann, C. Daniel   +7 more
semanticscholar   +1 more source

The Emerging Role of Complement Proteins as a Target for Therapy of IgA Nephropathy

Frontiers in Immunology, 2019
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is necessary for diagnosis, with routine immunofluorescence microscopy revealing dominant ...
Dana V. Rizk, Nicolas Maillard, Bruce A. Julian, Barbora Knoppova, Barbora Knoppova, Todd J. Green, Jan Novak, Robert J. Wyatt   +7 more
doaj   +1 more source

Pathway Realisability in Chemical Networks [PDF]

arXiv, 2023
The exploration of pathways and alternative pathways that have a specific function is of interest in numerous chemical contexts. A framework for specifying and searching for pathways has previously been developed, but a focus on which of the many pathway solutions are realisable, or can be made realisable, is missing.
arxiv  

Plasma Proteomic Analysis Reveals the Potential Role of Lectin and Alternative Complement Pathways in IgA Vasculitis Pathogenesis

Diagnostics, 2023
Background: IgA vasculitis (IgAV) is the most common form of childhood vasculitis. A better understanding of its pathophysiology is required to identify new potential biomarkers and treatment targets.
Selcan Demir, Idil Yet, Melis Sardan Ekiz, Erdal Sag, Yelda Bilginer, Omur Celikbicak, Incilay Lay, Seza Ozen   +7 more
doaj   +1 more source

Metalated Porous-Organic-Polymer Renders Mustard-Gas Simulant Harmless: Core Planarity Matters [PDF]

arXiv, 2022
The presence of open active metal sites in Metal-Organic Frameworks (MOFs) exhibit higher catalytic activity. However, rational accomplishment of MOFs in heterogeneous catalysis is limited due to coordination bonds. Recently balanced characteristic feature with combination of both the covalent bonds (structural stability) and open metal sites (single ...
arxiv  

Alternative Pathway Inhibition by Exogenous Factor H Fails to Attenuate Inflammation and Vascular Leakage in Experimental Pneumococcal Sepsis in Mice. [PDF]

PLoS ONE, 2016
Streptococcus pneumoniae is a common cause of sepsis. Effective complement activation is an important component of host defence against invading pathogens, whilst excessive complement activation has been associated with endothelial dysfunction and organ ...
Erika van der Maten, Saskia van Selm, Jeroen D Langereis, Hester J Bootsma, Fred J H van Opzeeland, Ronald de Groot, Marien I de Jonge, Michiel van der Flier   +7 more
doaj   +1 more source

Heme Interactions as Regulators of the Alternative Pathway Complement Responses and Implications for Heme-Associated Pathologies

Current Issues in Molecular Biology, 2023
Heme (Fe2+-protoporphyrin IX) is a pigment of life, and as a prosthetic group in several hemoproteins, it contributes to diverse critical cellular processes. While its intracellular levels are tightly regulated by networks of heme-binding proteins (HeBPs)
Stefanos A. Tsiftsoglou
doaj   +1 more source

A meridian lemma for fully alternating links in thickened surfaces [PDF]

arXiv, 2022
Menasco showed that a closed surface in the complement of a non-split prime alternating link in $S^3$ contains a circle isotopic in the link complement to a meridian of the links. This result is known as the meridian lemma for alternating links. We give a meridian lemma for the class of fully alternating links in the thickened orientable surfaces of ...
arxiv