Results 101 to 110 of about 6,006,467 (356)

Inhibiting Alternative Pathway Complement Activation by Targeting the Factor D Exosite*

Journal of Biological Chemistry, 2012
Background: Anti-factor D antibody blocks a rate-limiting step in the alternative complement pathway. Results: The structure of anti-factor D in complex with factor D provides the molecular basis of complement inhibition.
K. Katschke, Ping Wu, R. Ganesan, R. Kelley, M. Mathieu, P. Hass, Jeremy Murray, D. Kirchhofer, C. Wiesmann, M. van Lookeren Campagne   +9 more
semanticscholar   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Editorial: Role of complement activation in kidney diseases

Frontiers in Medicine, 2023
Takashi Oda, Toshihiro Sawai
doaj   +1 more source

Quantification of the Dynamics of the Vascular Flows in the Cerebral Arterial and Venous Trees

Biomedicines
Objective: Cerebral vascularization is made of the symmetrical arterial system, with muscular walls, and the venous system, more variable and dominated by sinuses and jugular veins.
Heimiri Monnier, Kimi Owashi, Pan Liu, Serge Metanbou, Cyrille Capel, Olivier Balédent   +5 more
doaj   +1 more source

Factor H-related Protein 4 Activates Complement by Serving as a Platform for the Assembly of Alternative Pathway C3 Convertase via Its Interaction with C3b Protein

Journal of Biological Chemistry, 2012
Background: Complement factor H-related protein 4 (CFHR4) has been shown to interact with C3b. Results: Binding of C3b to CFHR4 allows the formation of an active alternative pathway C3 convertase.
M. Hebecker, M. Józsi
semanticscholar   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Deficiencias de los componentes de las vías de activación clásica y alternativa del sistema del complemento Deficiencies of the components of the classic and alternative activation pathways of the complement system

Revista Cubana de Hematología, Inmunología y Hemoterapia, 2006
Las deficiencias congénitas de los componentes individuales de las vías clásica y alternativa del sistema del complemento, dan lugar a un conjunto de enfermedades de frecuencia relativamente baja. Las personas con deficiencias en estas funciones muestran
Yanelkys Cos Padrón, Vianed Marsán Suárez, Rinaldo Villaescusa Blanco, Consuelo Macías Abraham   +3 more
doaj  

Elevated Systemic Pentraxin-3 Is Associated With Complement Consumption in the Acute Phase of Thrombotic Microangiopathies

Frontiers in Immunology, 2019
Pentraxin-3 (PTX3) and C-reactive protein (CRP) have been shown to regulate complement activation in vitro, but their role has not been investigated in complement consumption in vivo. Thrombotic microangiopathies (TMA) are often accompanied by complement
Eszter Trojnar, Mihály Józsi, Zsóka Szabó, Marienn Réti, Péter Farkas, Kata Kelen, George S. Reusz, Attila J. Szabó, Attila J. Szabó, Nóra Garam, Bálint Mikes, György Sinkovits, Blanka Mező, Dorottya Csuka, Zoltán Prohászka   +14 more
doaj   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source