Results 221 to 230 of about 782,609 (335)

Interferon-β1a-Induced Thrombotic Microangiopathy: Possible Implication of the Alternative Pathway of the Complement. [PDF]

Kidney Int Rep, 2022
Taghavi M, Stordeur P, Collart F, Dachy B, Pozdzik A, Mesquita MDCF, Nortier J.   +6 more
europepmc   +1 more source

The third component of complement: covalent attachment of a radioactive sugar to the labile binding site of C3 via the alternative pathway. [PDF]

, 1981
Joseph L. Mann, Roberta O'Brien, Margaret K. Hostetter, Chester A. Alper, Fred S. Rosen, BM Babior   +5 more
openalex   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

Baicalin relieves complement alternative pathway activation-induced lung inflammation through inhibition of NF-κB pathway. [PDF]

BMC Complement Med Ther
Li J, Zhang QY, Lu QY, Liu QZ, Guo L, Li M, Sun QY.   +6 more
europepmc   +1 more source

Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation. [PDF]

Front Immunol, 2022
Gerogianni A, Dimitrov JD, Zarantonello A, Poillerat V, Chonat S, Sandholm K, McAdam KE, Ekdahl KN, Mollnes TE, Mohlin C, Roumenina LT, Nilsson PH.   +11 more
europepmc   +1 more source

The Role of Properdin As a Modulator of the Alternative Pathway

, 1976
Roxane Spitzer, Ann E. Stitzel, Joan Urmson   +2 more
openalex   +1 more source

Factor B, the complement alternative pathway serine proteinase, is a major constitutive protein synthesized and secreted by resident and elicited mouse macrophages. [PDF]

, 1985
John S. Sundsmo, Jennie R. Chin, Ruth A. Papin, Daryl S. Fair, Zena Werb   +4 more
openalex   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Editorial: The Role of Complement in Health and Disease

Frontiers in Immunology, 2019
Maciej Cedzyński, Nicole M. Thielens, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Thomas Vorup-Jensen, Thomas Vorup-Jensen   +6 more
doaj   +1 more source

Reconstitution of the alternative pathway of the complement system enables rapid delineation of the mechanism of action of novel inhibitors. [PDF]

J Biol Chem
Goodrich AC, LeClair NP, Shillova N, Morton WD, Wittwer AJ, Loyet KM, Hannoush RN.   +6 more
europepmc   +1 more source