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The alternative pathway of complement
Springer Seminars in Immunopathology, 1984The alternative pathway of complement activation provides the host with a humoral component of the natural defense mechanisms against infectious agents. The six plasma proteins involved in recognition and activation perform a continuous surveillance function that does not require specific antibody to recognize potential pathogens.
M K, Pangburn, H J, Müller-Eberhard
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The alternative antigen pathway
Immunology Today, 1989In this article, John Tew, Marie Kosco and Andras Szakal describe progress in deciphering a novel antigen pathway that represents an alternative to classical clearance by phagocytes. Upon booster immunization, immune complexes form rapidly and these complexes are handled not only by phagocytes but also by a series of non-phagocytic cells in a distinct ...
J G, Tew, M H, Kosco, A K, Szakal
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Alternative pathway amplification and infections
Immunological Reviews, 2022SummaryThe alternative pathway (AP) is the phylogenetically oldest arm of the complement system and may have evolved to mark pathogens for elimination by phagocytes. Studies using purified AP proteins or AP‐specific serum showed that C3b amplification on bacteria commenced following a lag phase of about 5 min and was highly dependent on the ...
Jutamas Shaughnessy +3 more
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Diagnosis of complement alternative pathway disorders
Kidney International, 2016 Kidney diseases resulting from abnormal control of the complement alternative pathway include atypical hemolytic uremic syndrome, C3 glomerulonephritis, and dense-deposit disease, as well as atypical postinfectious glomerulonephritis. Although clinically
Andrea Angioï +2 more
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Alternative Pathway Evaluation
Current Protocols in Immunology, 1994AbstractThe alternative pathway of complement shares its terminal components (C3 and C5 through 9) with the classical pathway, but has several unique components, including factors D, B, and P (properdin). This unit presents methods for assaying total alternative pathway activity and the activity of factors B and D. Radial immunodiffusion (RID) can also
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The complement alternative pathway and hemostasis
Immunological Reviews, 2022SummaryThe complement and hemostatic systems are complex systems, and both involve enzymatic cascades, regulators, and cell components—platelets, endothelial cells, and immune cells. The two systems are ancestrally related and are defense mechanisms that limit infection by pathogens and halt bleeding at the site of vascular injury.
Marina Noris, Miriam Galbusera
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Alternating Views on the ABR Alternate Pathway
RadiologyThe alternate pathway to American Board of Radiology certification has recently gained traction among international graduates; drawing from personal experiences, we summarize the challenges candidates may face, hoping to prepare potential candidates for the hurdles ahead.
Adarsh Ghosh, Eric Crotty
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The Complement Alternative Pathway and Preeclampsia
Current Hypertension Reports, 2018Significant and intricate immune adaptations are essential for the establishment and maintenance of normal pregnancy. Preeclampsia is a morbid, potentially life-threatening disease for both mother and neonate that occurs uniquely in pregnancy, at least in part, due to maternal immune maladaptation.
Layan, Alrahmani +1 more
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Alternate interferon signaling pathways
Pharmacology & Therapeutics, 2003More than a half a century ago, interferons (IFN) were identified as antiviral cytokines. Since that discovery, IFN have been in the forefront of basic and clinical cytokine research. The pleiotropic nature of these cytokines continues to engage a large number of investigators to define their actions further.
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The Alternative Pathway of Complement Activation
1976Publisher Summary This chapter presents the alternative pathway of complement activation. Two pathways for the recruitment of complement and its biological activities exist in plasma and serum. The first is termed as the “classical pathway,” which is triggered by contact of C1 with immune complexes containing antibodies of the immunoglobulin G (IgG ...
O, Götze, H J, Müller-Eberhard
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