Results 221 to 230 of about 1,689,260 (355)

Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19. [PDF]

Immunology, 2023
Siggins MK, Davies K, Fellows R, Thwaites RS, Baillie JK, Semple MG, Openshaw PJM, Zelek WM, Harris CL, Morgan BP, ISARIC4C Investigators.   +10 more
europepmc   +1 more source

Is Complement Alternative Pathway Disregulation Involved in Veno-Occlusive Disease of the Liver? [PDF]

, 2010
Alessandro Bucalossi, Francesca Toraldo, Monica Tozzi, Mariapia Lenoci, Cinzia Castagnini, Rosangela Artuso, Alessandra Renieri, Giuseppe Marotta   +7 more
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Pediatric Immunodeficiency Caused by Complement Classical and Alternative Pathway Defects Due to a Homozygous CFI Variant: A Case Report. [PDF]

Cureus
Wei J, Liu C, Tian M, Cao G, Li J.
europepmc   +1 more source

The potential role of complement alternative pathway activation in hypertensive renal damage. [PDF]

Exp Biol Med (Maywood), 2022
Wang C, Wang Z, Zhang W.
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction. [PDF]

Nat Commun, 2023
Sülzen H, Began J, Dhillon A, Kereïche S, Pompach P, Votrubova J, Zahedifard F, Šubrtova A, Šafner M, Hubalek M, Thompson M, Zoltner M, Zoll S.   +12 more
europepmc   +1 more source

The Same Receptor, G Protein, and Mitogen-activated Protein Kinase Pathway Activate Different Downstream Regulators in the Alternative White and Opaque Pheromone Responses ofCandida albicans

, 2007
Song Yi, Nidhi Sahni, Karla J. Daniels, Claude Pujol, Thyagarajan Srikantha, David R. Soll   +5 more
openalex   +2 more sources

Xenotransplanted Pig Sertoli Cells Inhibit Both the Alternative and Classical Pathways of Complement-Mediated Cell Lysis While Pig Islets Are Killed [PDF]

, 2016
Kandis Wright, Rachel Dziuk, Payal Mital, Gurvinder Kaur, Jannette M. Dufour   +4 more
openalex   +1 more source

60 Pattern recognition plays a role in the initiation of the alternative complement pathway

, 2023
Kevin Widmer, Jean-Luc Mary, Corinne Stucki, Elöd Körtvely   +3 more
openalex   +1 more source