Results 51 to 60 of about 7,204,743 (394)
Alternative Excision Repair Pathways [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Alternative excision repair (AER) is a category of excision repair initiated by a single nick, made by an endonuclease, near the site of DNA damage, and followed by excision of the damaged DNA, repair synthesis, and ligation. The ultraviolet (UV) damage endonuclease in fungi and bacteria introduces a nick immediately 5' to various types of UV damage ...
openaire +2 more sources
Autoantibodies against complement factor B in rheumatoid arthritis
Frontiers in Immunology, 2023 Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder affecting the joints. Many patients carry anti-citrullinated protein autoantibodies (ACPA).
Alexandra T. Matola +12 more
doaj +1 more source
Haematologica, 2016 Paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome are diseases of excess activation of the alternative pathway of complement that are treated with eculizumab, a humanized monoclonal antibody against the terminal complement ...
Xuan Yuan +8 more
semanticscholar +1 more source
Functional evaluation of rare variants in complement factor I using a minigene assay
Frontiers in ImmunologyThe regulatory serine protease, complement factor I (FI), in conjunction with one of its cofactors (FH, C4BP, MCP, or CR1), plays an essential role in controlling complement activity through inactivation of C3b and C4b.
Cobey J. H. Donelson +4 more
doaj +1 more source
A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling. [PDF]
, 2018 Detection of viral genomes by the innate immune system elicits an antiviral gene program mediated by type I interferons (IFNs). While viral RNA and DNA species induce IFN via separate pathways, the mechanisms by which these pathways are differentially ...
Aliyari, Saba Roghiyh +9 more
core
Alternative final steps in berberine biosynthesis in Coptis japonica cell cultures [PDF]
, 1988 In Coptis japonica cell cultures an alternative pathway has been discovered which leads from (S)-tetrahydrocolumbamine via (S)-canadine to berberine. The two enzymes involved have been partially purified.
Galneder, E. +4 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT The pediatric hematology‐oncology fellowship training curriculum has not substantially changed since its inception. The first year of training is clinically focused, and the second and third years are devoted to scholarship. However, this current structure leaves many fellows less competitive in the current job market, resulting in ...
Scott C. Borinstein +3 more
wiley +1 more source
Factor H-related protein 1 in systemic lupus erythematosus
Frontiers in ImmunologyBackgroundFactor H (FH) is a major soluble inhibitor of the complement system and part of a family comprising five related proteins (FHRs 1–5). Deficiency of FHR1 was described to be linked to an elevated risk of systemic lupus erythematosus (SLE).
Jessica S. Kleer +9 more
doaj +1 more source
Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration. [PDF]
, 2018 Nematode EAK-7 (enhancer-of-akt-1-7) regulates dauer formation and controls life span; however, the function of the human ortholog mammalian EAK-7 (mEAK-7) is unknown.
Fox, Alexandra Lucienne +5 more
core +2 more sources
Quantitative Modeling of the Alternative Pathway of the Complement System
PLoS ONE, 2016 The complement system is an integral part of innate immunity that detects and eliminates invading pathogens through a cascade of reactions. The destructive effects of the complement activation on host cells are inhibited through versatile regulators that
Nehemiah T. Zewde +3 more
semanticscholar +1 more source