Results 61 to 70 of about 668 (185)

Food Safety in Developing Countries: Common Foodborne and Waterborne Illnesses, Regulations, Organizational Structure, and Challenges of Food Safety in the Context of Nepal

Food Frontiers, Volume 6, Issue 1, Page 86-123, January 2025.
Food safety presents a global challenge, contributing to 600 million cases of foodborne diseases and 420,000 fatalities annually worldwide. A multisectoral One Health approach involving collaboration among government agencies, food industry stakeholders, consumers, and civil society organizations is imperative to enhance food safety in developing ...
Deepak Subedi, Madhav Paudel, Sandesh Poudel, Niranjan Koirala   +3 more
wiley   +1 more source

A rapid radioimmunoassay, using a nylon support, for amatoxins from amanita mushrooms

, 1982
A fetuin derivative of alpha-amanitin was prepared and used as an antigen in rabbits. The antigen was superior to previous bovine serum albumin derivatives of beta-amanitin by its lower toxicity and high immunogenicity.
Faulstich, H., Zobeley, S., Trischmann, H.   +2 more
core   +1 more source

Morchella esculenta (L.) Pers. Wild of the Province of Taza, Morocco: Toxicity Assessment in In Vitro and In Vivo Models, Antioxidant Activities and Correlation With the Chemical Composition of Aqueous and Organic Extracts

Biochemistry Research International, Volume 2025, Issue 1, 2025.
Mushrooms are a source of nutrients and bioactive substances. This work, carried out for the first time, aims to evaluate in vitro and in vivo toxicity and antioxidant potential of the wild edible mushroom from the province of Taza, Morocco: Morchella esculenta (L.) Pers., the extraction is carried out using two methods: aqueous and organic.
Asmae Mahtal, Fatima Lamchouri, Nacima Lachkar, Hafida Bouhazama, Hamid Toufik, Harleen Khatra   +5 more
wiley   +1 more source

VISTA‐targeted antibody‐drug conjugates exhibit potent antitumor effects on malignant pleural mesothelioma

MedComm – Oncology, Volume 3, Issue 2, June 2024.
In this study, moderate to high V‐domain immunoglobulin T‐cell activation suppressor (VISTA) expression levels were observed in most malignant pleural mesothelioma (MPM) clinical tumor samples. We generated two novel VISTA‐targeted antibody‐drug conjugates by conjugating anti‐VISTA mAbs with the potent cytotoxic drug monomethyl auristatin E, which ...
Jingyue Kang, Zongliang Zhang, Ruyuan Zhang, Meijun Zheng, Caiying Jiang, Hui Yang, Aiping Tong, Yan Zhang   +7 more
wiley   +1 more source

Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases—A comprehensive narrative review

Food Science &Nutrition, Volume 12, Issue 5, Page 3097-3111, May 2024.
A thorough examination of the substantiating evidence supporting its use as an adjunctive therapy for individuals grappling with liver‐related conditions. Abstract Liver diseases, encompassing conditions such as cirrhosis, present a substantial global health challenge with diverse etiologies, including viral infections, alcohol consumption, and non ...
Hafiza Madiha Jaffar, Fahad Al‐Asmari, Faima Atta Khan, Muhammad Abdul Rahim, Eliasse Zongo   +4 more
wiley   +1 more source

Hepatotoxicity from ingestion of wild mushrooms of the genus Amanita section Phalloideae collected in Mexico City: two case reports

Annals of Hepatology, 2011
We present two cases of acute liver injury resulting from consumption of wild mushrooms. The first case was a male who developed acute hepatitis after ingestion of diverse mushrooms including Amanita species.
Jorge Méndez-Navarro, Nayeli X. Ortiz-Olvera, Margarita Villegas-Ríos, Luis J. Méndez-Tovar, Karin L. Andersson, Rosalba Moreno-Alcantar, Víctor E. Gallardo-Cabrera, Sergio Félix, Carlos Galván, Gilka Vargas, Luz M. Gómez, Margarita Dehesa-Violante   +11 more
doaj   +1 more source

5‐Hydroxypyrroloindoline Affords Tryptathionine and 2,2′‐bis‐Indole Peptide Staples: Application to Melanotan‐II

Chemistry – A European Journal, Volume 30, Issue 19, April 2, 2024.
Optionality for Indole‐based Peptide Stapling: hydroxypyrroloindoline, used regularly in reaction with cysteine to form a tryptathionine (Ttn) staple is found to react competitively with an indole to form a 2’2’‐bis‐indole tether (BITe). Judicious choice of protecting groups provides for chemoselectivity for optionality in terms of which staple is ...
Mihajlo Todorovic, Antoine Blanc, Zhou Wang, Jerome Lozada, Juliette Froelich, Jutta Zeisler, Chengcheng Zhang, Helen Merkens, Francois Benard, David M. Perrin   +9 more
wiley   +1 more source

Methodologies for synthesis of transcription inhibiting peptides, amatoxins, and their bioconjugates for targeted cancer therapy

, 2022
This thesis describes my contribution to the development of synthetic methods directed at accessing bicyclic toxic peptides, amatoxins, as well as amatoxin-based bioconjugates for targeted treatment of cancer.
Pryyma, Alla
core  

A New Conjugation Method Used for the Development of an Immunoassay for the Detection of Amanitin, a Deadly Mushroom Toxin

Toxins, 2018
One of the deadliest mushrooms is the death cap mushroom, Amanita phalloides. The most toxic constituent is α-amanitin, a bicyclic octapeptide, which damages the liver and kidneys.
Candace S. Bever, Bogdan Barnych, Robert Hnasko, Luisa W. Cheng, Larry H. Stanker   +4 more
doaj   +1 more source

Bicyclic peptides: Paving the road for therapeutics of the future

Peptide Science, Volume 116, Issue 2, March 2024.
Abstract Bicyclic peptides have emerged as one of the driving forces within the constrained peptide family. Due to their unique pharmaceutical attributes, peptide bicycles have garnered a reputation as promising therapeutics of the future. Combining advantages of small molecule therapeutics and biologics, the target binding qualities of this highly ...
Sven Ullrich, Christoph Nitsche
wiley   +1 more source