Results 11 to 20 of about 170,643 (213)

Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome

Nature Communications, 2023
Aminoglycosides are a class of antibiotics that bind to ribosomal RNA and exert pleiotropic effects on ribosome function. Amikacin, the semisynthetic derivative of kanamycin, is commonly used for treating severe infections with multidrug-resistant ...

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The Direction of the Antibacterial Effect of Rutin Hydrate and Amikacin

Antibiotics, 2023
The aim of the presented study was to examine the in vitro antimicrobial activity of rutin hydrate (RH) alone and in combination with amikacin against 12 reference strains of Gram-positive and Gram-negative bacteria.
Maria Miklasińska-Majdanik, M. Kępa, Tomasz J. Wąsik, Karolina Zapletal-Pudełko, Magdalena Klim, R. Wojtyczka   +5 more
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Amikacin-loaded niosome nanoparticles improve amikacin activity against antibiotic-resistant Klebsiella pneumoniae strains

World Journal of Microbiology & Biotechnology, 2022
Amikacin is an aminoglycoside antibiotic used in drug-resistant bacterial infections. The spread of bacterial infections has become a severe concern for the treatment system because of the simultaneous drug resistance bacteria and SARS-CoV-2 hospitalized
M. Rahmati, Ebrahim Babapoor, M. Dezfulian   +2 more
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Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and amikacin

Cochrane Database of Systematic Reviews, 2021
Background The World Health Organization (WHO) End TB Strategy stresses universal access to drug susceptibility testing (DST). DST determines whether Mycobacterium tuberculosis bacteria are susceptible or resistant to drugs.
S. Pillay, K. Steingart, G. Davies, Marty Chaplin, M. de Vos, S. Schumacher, R. Warren, G. Theron   +7 more
semanticscholar   +1 more source

Robustness of Aerosol Delivery of Amikacin Liposome Inhalation Suspension using the eFlow® Technology.

European journal of pharmaceutics and biopharmaceutics, 2021
The purpose of these studies was to understand the effect on product performance of batch-to-batch variability in both the amikacin liposome inhalation suspension (ALIS) formulation and its delivery device, the Lamira® nebulizer system, designed and ...
Zhili Li, W. Perkins, D. Cipolla
semanticscholar   +1 more source

The role of amikacin in the treatment of nontuberculous mycobacterial disease

Expert Opinion on Pharmacotherapy, 2021
Introduction: Guidelines recommend the use of amikacin in the treatment of nontuberculous mycobacterial (NTM) disease. The authors have evaluated the evidence for the position of amikacin in NTM disease treatment.
J. Raaijmakers, J. Schildkraut, W. Hoefsloot, J. van Ingen   +3 more
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Low-dose amikacin in the treatment of Multidrug-resistant Tuberculosis (MDR-TB)

BMC Infectious Diseases, 2021
Background The World Health Organization recommends intravenous amikacin for the treatment of MDR-TB at a dose of 15 mg/kg. However, higher doses are associated with significant toxicity.
Natasha F. Sabur, M. Brar, Lisa Wu, S. Brode   +3 more
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Population Pharmacokinetic Evaluation of Amikacin Liposome Inhalation Suspension in Patients with Treatment-Refractory Nontuberculous Mycobacterial Lung Disease

European journal of drug metabolism and pharmacokinetics, 2021
Use of parenteral amikacin to treat refractory nontuberculous mycobacterial (NTM) lung disease is limited by systemic toxicity. A population pharmacokinetic model was developed using data pooled from two randomized trials to evaluate the pharmacokinetic ...
C. Rubino, N. Onufrak, J. van Ingen, D. Griffith, S. Bhavnani, D. Yuen, K. Mange, K. Winthrop   +7 more
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Amikacin liposome inhalation suspension for chronic Pseudomonas aeruginosa infection in cystic fibrosis.

Journal of Cystic Fibrosis, 2020
BACKGROUND Shortcomings of inhaled antibiotic treatments for Pseudomonas aeruginosa infection in patients with cystic fibrosis (CF) include poor drug penetration, inactivation by sputum, poor efficiency due to protective biofilm, and short residence in ...
D. Bilton, T. Pressler, I. Fajac, J. Clancy, D. Sands, P. Minić, M. Cipolli, I. Galeva, A. Solé, A. Quittner, Keith Liu, J. P. Mcginnis, G. Eagle, Renu Gupta, M. Konstan   +14 more
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Renal Impact of a High-Loading Dose of Amikacin in Critically Ill Patients [PDF]

Pharmaceutical Sciences
Background: Aminoglycosides are potent bactericidal antibiotics primarily employed for gram-negative infections. However, they face limitations due to potential renal toxicity when administered at high doses. This study aimed to assess the nephrotoxicity
Laleh Mahmoudi, Arezoo Ahmadi, Motahareh Mahi-Birjand, Effat Alemzadeh, Parvin Askari, Ramin Niknam, Mojtaba Mojtahedzadeh   +6 more
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