Results 91 to 100 of about 15,918,440 (250)

The NAT10/ac4C axis: a central nexus linking RNA acetylation to immunometabolic signaling in disease

Cell Communication and Signaling
RNA modifications represent a fundamental layer of epitranscriptomic regulation. Among them, N 4-acetylcytidine (ac4C)—a highly conserved and functionally versatile mark deposited by N-acetyltransferase 10 (NAT10)—has recently emerged as a critical ...
Caiyun Shang, Xiaoxue Wang, Yanling Huang, Jingyi Zhu, Xueqian Liu, Heng Zhang, Wuxiang Guan, Haojie Hao, Fang Zhang   +8 more
doaj   +1 more source

MurNAc‐Based Electrophilic Inhibitors of O‐Acetylpeptidoglycan Esterase (Ape): Design, Synthesis, and Kinetic Evaluation

Chemistry – A European Journal, EarlyView.
A series of N‐acetylmuramic acid (MurNAc)‐based electrophilic inhibitors targeting Ape esterase was synthesized. Their inhibitory potency ranged from micromolar to submillimolar. The study probed binding contributions of stem peptide extension, replacing the anomeric methyl group with a benzyl, and α‐fluorination of the carbonyl to enhance ...
Dmytro Voskoboinyk, Martin E. Tanner
wiley   +1 more source

Functional characterization of serotonin N-acetyltransferases from Caenorhabditis elegans and enhanced senescence tolerance in transgenic rice overexpressing CeSNAT1 via melatonin increase

Plant Stress
The nematode Caenorhabditis elegans is a model invertebrate for investigating melatonin function and diverse behaviors. It synthesizes melatonin in a circadian manner, peaking at night; however, the key gene encoding serotonin N-acetyltransferase (SNAT ...
Kyungjin Lee, Kyoungwhan Back
doaj   +1 more source

Characterization of NAT2 Using Long‐Read Sequencing: Allele, Diplotype, and Phenotype Call Accuracy Compared to Other Testing Strategies

Clinical Pharmacology &Therapeutics, EarlyView.
The NAT2 pharmacogene is essential in drug metabolism, particularly for aromatic amines and hydrazines. Genetic variations in NAT2 categorize individuals as rapid, intermediate, or poor metabolizers based on their acetylation capacity to inform dosing guidelines.
Shobana John, Erin C. Boone, Byunggil Yoo, Laura B. Ramsey, Andrea Gaedigk   +4 more
wiley   +1 more source

Metabolomic Profiling of Fatty Acid and Amino AcidMetabolism in Youth With Obesity and Type 2 Diabetes [PDF]

, 2012
OBJECTIVE We compared acylcarnitine (AcylCN) species, common amino acid and fat oxidation (FOX) byproducts, and plasma amino acids in normal weight (NW; n = 39), obese (OB; n = 64), and type 2 diabetic (n = 17) adolescents.
Bacha, Fida, Michaliszyn, Sara F., Mihalik, Stephanie J., Chace, Donald H., Arslanian, Silva A., Lee, SoJung, De las Heras Montero, Javier Adolfo, DeJesus, Victor R., Vockley, Jerry   +8 more
core   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

NAT10 as a central node in cancer biology: integrating epitranscriptomic regulation, metabolic reprogramming, and immune modulation

Frontiers in Immunology
N-acetyltransferase 10 (NAT10), the sole known mRNA N4-acetylcytidine (ac4C) writer, has emerged as a central regulator of cancer adaptation. Beyond its canonical role in RNA acetylation, NAT10 integrates environmental stress signals—including hypoxia ...
Wentao Bo, Ying Yi, Biao Zhao, Hang Dong
doaj   +1 more source

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source

Integrated proteomic and transcriptomic analyses of Citrus australasica in response to Candidatus Liberibacter asiaticus infection

BMC Plant Biology
Background Candidatus Liberibacter asiaticus (CLas) is the most prevalent pathogen causing the globally prevalent citrus Huanglongbing (HLB). The citrus relative Citrus australasica F. Muell. shows tolerance to HLB. In this study, we grafted HLB-tolerant
Xiaoxiao Wu, Chuanwu Chen, Haimeng Fang, Xuefeng Wang, Chongling Deng, Jing Feng, Qiuling Pang, Yang Han, Feng Zhang, Hongbing Li, Binghai Lou   +10 more
doaj   +1 more source

Alginate Polymerization and Modification Are Linked in Pseudomonas aeruginosa

mBio, 2015
The molecular mechanisms of alginate polymerization/modification/secretion by a proposed envelope-spanning multiprotein complex are unknown. Here, bacterial two-hybrid assays and pulldown experiments showed that the catalytic subunit Alg8 directly ...
M. Fata Moradali, Ivan Donati, Ian M. Sims, Shirin Ghods, Bernd H. A. Rehm   +4 more
doaj   +1 more source