Results 231 to 240 of about 67,441 (359)

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Modulation of the growth performance, amino acid digestibility, and jejunal integrity of broiler chickens by dietary inclusion of raw potato starch or high-amylose corn starch in a mixed-Eimeria challenge model. [PDF]

Poult Sci
Oluseyifunmi IW, Olukosi OA.
europepmc   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

Effect of processing techniques on energy content and amino acid digestibility in corn germ meal fed to growing pigs. [PDF]

Anim Biosci
Zhao J, Liu Z, Song X, Yang M, Li Z, Liu L.   +5 more
europepmc   +1 more source

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

True metabolizable energy, standardized amino acid digestibility, phosphorus digestibility, and phosphorus bioavailability of fermented soybean meal and fermented full-fat soybeans fed to chickens. [PDF]

Poult Sci
Cristobal M, Utterback PL, Stein HH, Parsons CM.   +3 more
europepmc   +1 more source

The Effects of Cellulose, Pectin and Starch on Standardized Ileal and Apparent Total Tract Amino Acid Digestibilities and Bacterial Contribution of Amino Acids in Feces of Growing Pigs [PDF]

, 2008
Q. G., Barbara U. Metzler-Zebeli, M. Eklund, Cheng Ji, R. Mosenthin   +4 more
openalex   +1 more source

ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment

Advanced Science, EarlyView.
ETV4 coordinates a dual transcriptional program by upregulating MET and asparagine synthetase (ASNS). The resulting asparagine (Asn) secretion acts as a metabolic signal, reprogramming hepatic stellate cells (HSCs) and primary cancer‐associated fibroblasts (CAFs) toward an inflammatory phenotype. These activated stromal cells release HGF to sustain the
Dujiang Fu, Meijia Zhang, Maoping Cai, Miao Wang, Ziao Huang, Zesheng Lin, Yixin Liu, Wang Qian, Guopeng Chen, Yuxing Liang, Dongyi Wei, Jing xie, Picheng Yan, Yuanyuan Qu, Yongchang Wei   +14 more
wiley   +1 more source

Determination and Prediction of Amino Acid Digestibility in Rapeseed Cake for Growing-Finishing Pigs. [PDF]

Animals (Basel)
Tang H, Feng G, Zhao J, Ouyang Q, Liu X, Jiang X, Deng M, Xie Z, Chen F, Zhou X, Li R, Yin Y.   +11 more
europepmc   +1 more source

Variations in the chemical composition and standardized ileal digestibility of amino acids in eight genotypes of triticale fed to growing pigs1,2 [PDF]

, 2017
E. J. P. Strang, M. Eklund, P. Rosenfelder, John K Htoo, R. Mosenthin   +4 more
openalex   +1 more source