Results 241 to 250 of about 3,092,210 (299)

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

Amino acid digestibility and protein quality of fermented soybean-based ingredients using the precision-fed cecectomized rooster assay. [PDF]

J Anim Sci
Smola MA, Utterback PL, Parsons CM, Chen X, Chen Z, Liu Y, Ng PKW, Swanson KS.   +7 more
europepmc   +1 more source

Impact of nutrient density diet with emulsifier supplementation on apparent total tract digestibility and ileal amino acid digestibility in broilers. [PDF]

Poult Sci
Kumar SS, Park JH, Kim IH.
europepmc   +1 more source

Comparison of Amino Acid Digestibility between Commercial Crossbred Pigs and Mini-Jeju Island Native Pigs. [PDF]

Animals (Basel)
Jo H, Htoo JK, Kim BG.
europepmc   +1 more source

Standardized ileal amino acid digestibility estimates are not additive in extruded canine diets with an increasing inclusion of whole pulse flour ingredients. [PDF]

J Anim Sci
Banton S, Templeman JR, Oba PM, Swanson KS, Saunders-Blades J, Shoveller AK.   +5 more
europepmc   +1 more source

Effects of chronic exposure of specific water quality parameters in poultry drinking water on dietary amino acid digestibility and early broiler performance. [PDF]

Poult Sci
Raut R, Biswas BK, Taylor-Bowden T, Kilonzo-Nthenge A, Pokharel B, Tabler T, Nahashon SN, Maharjan P.   +7 more
europepmc   +1 more source

Exposure to Subclinical Doses of Fumonisins, Deoxynivalenol, and Zearalenone Affects Immune Response, Amino Acid Digestibility, and Intestinal Morphology in Broiler Chickens. [PDF]

Toxins (Basel)
Shanmugasundaram R, Kappari L, Pilewar M, Jones MK, Olukosi OA, Pokoo-Aikins A, Applegate TJ, Glenn AE.   +7 more
europepmc   +1 more source