Results 51 to 60 of about 23,258 (194)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Comparison of Cricket Protein Powder and Whey Protein Digestibility

Molecules
With the global population projected to reach nine billion by 2050, the search for alternative protein sources has become critical. This study evaluated the digestibility of cricket protein powder compared with that of whey protein powder.
Barbora Lampová, Ivo Doskočil, Petr Šmíd, Lenka Kouřimská   +3 more
doaj   +1 more source

Protein Quality and Protein Digestibility of Vegetable Creams Reformulated with Microalgae Inclusion

Foods, 2023
Microalgae are considered a valuable source of proteins that are used to enhance the nutritional value of foods. In this study, a standard vegetable cream recipe was reformulated through the addition of single-cell ingredients from Arthrospira platensis (
Barbara Prandi, Fatma Boukid, Simon Van De Walle, Sara Cutroneo, Josep Comaposada, Geert Van Royen, Stefano Sforza, Tullia Tedeschi, Massimo Castellari   +8 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Digestibility coefficient and true digestible amino acid values of different cultivars of maize for poultry

Semina: Ciências Agrárias, 2015
The digestibility and true digestible amino acid content of eight cultivars of maize was determined using the method of force-feeding roosters cecectomized.
Márcia Antonia Bartolomeu Agustini , Ricardo Vianna Nunes, Yolanda Lopes da Silva , Flávio Medeiros Vieites, Cinthia Eyng, Arele Arlindo Calderano , Paulo Cesar Gomes   +6 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Influence of Dietary Phytate and Exogenous Phytase on Amino Acid Digestibility in Poultry: A Review

The Journal of Poultry Science, 2006
The effects of dietary phytate and microbial phytase supplementation on amino acid availability in poultry diets are of considerable practical importance. Published data on the influence of exogenous phytase supplementation on the ileal digestibility of
Peter H. Selle, Velmurugu Ravindran, Wayne L. Bryden, Tom Scott   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

True ileal amino acid digestibility and digestible indispensable amino acid scores (DIAASs) of cooked tropical peas

Food Research International
Tropical peas can be used as both animal feed and human food but the nutritional quality of their proteins for humans is currently poorly documented. Here, 3 varieties of tropical peas were studied at two stages of seed maturity (green or dry): Cajanus Cajan (CC), Vigna Unguiculata (VU) and Lablab Purpureus (LP).
David, Jérémie, Buffière, Caroline, Hafnaoui, Noureddine, Migné, Carole, Bambou, Jean-Christophe, Archimède, Harry, Rémond, Didier   +6 more
openaire   +2 more sources

Protein and amino acid digestibility of 15N Spirulina in rats

European Journal of Nutrition, 2020
Spirulina is often used as dietary supplement for its protein content and quality. However, in vivo data on protein digestibility are lacking. This study aims to determine nitrogen and amino acid digestibility in rats. A secondary objective was to test the effect of sonication prior to ingestion to break cell walls.Wistar rats were fed a single test ...
Tessier, Romain, Calvez, Juliane, Khodorova, N., Gaudichon, Claire   +3 more
openaire   +4 more sources