Results 151 to 160 of about 8,038 (247)

Branched‐Chain Amino and Keto Acids Reduce Hepatocyte Lipid Droplet Size and Number via Distinct Proteomic Pathways

PROTEOMICS, Volume 26, Issue 7, Page 146-157, July 2026.
ABSTRACT Branched‐chain amino acids (BCAA) and their corresponding keto acids (BCKA) have been associated with changes in hepatic lipid metabolism and the resulting alterations in intracellular triglyceride concentrations. In this study, we utilized a previously established hepatocyte model to investigate the impact of BCAA and BCKA supplementation on ...
Jayasimha R. Daddam, Mounica Sura, Edward Kolodziej, Maria Gojcaj, Zheng Zhou   +4 more
wiley   +1 more source

Protein Folding Problem

, 2007
This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation.
King, Jonathan
core  

Oxidized PDI promotes thrombus formation in oxidative stress. [PDF]

Blood
Yang M, Owegie OC, Patel A, Kennedy QP, Flaumenhaft JT, Chinnaraj M, Ponzar N, Fulcidor EM, Rico MC, Bhowmik A, Carroll KS, Handy DE, Loscalzo J, Essex DW, Pozzi N, Flaumenhaft R.   +15 more
europepmc   +1 more source

Redox signals and oxidative stress in the control of mitochondrial protein import

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Mitochondrial protein import is essential for organelle biogenesis and cellular homeostasis. It operates in an environment that is intrinsically shaped by redox chemistry. Mitochondria are major sources of reactive oxygen species (ROS), which arise as by‐products of oxidative phosphorylation. Cells therefore maintain sophisticated ROS‐handling
Lidwina Hasberg, Viktoria Katharina Lauterbach, Torsten Ochsenreiter, Jan Riemer   +3 more
wiley   +1 more source

SpiR is a gut microbial enzyme that drives cholesterol conversion. [PDF]

Nat Commun
Arp G, Levy S, Jiang AK, Dufault-Thompson K, Zhong A, Grant M, Li Y, Jiang X, Hall B.   +8 more
europepmc   +1 more source

Substrate scope of ancestral versus modern family‐1 glycosidases

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Experimental studies support that protein engineering based on ancestral sequence reconstruction often leads to variants with biotechnologically useful biomolecular properties. These may include high stability, enhanced conformational flexibility and a modified catalysis range.
Luis I. Gutierrez‐Rus, Dušan Petrović, Pascal Schneider, Katja Zorn, Gloria Gamiz‐Arco, Rocío Romero‐Zaliz, Ignacio Suarez‐Martin, Leonardo De Maria, Francesco Falcioni, Valeria A. Risso, Martin A. Hayes, Jose M. Sanchez‐Ruiz   +11 more
wiley   +1 more source

Alpha-class glutathione transferases as steroid isomerases and scaffolds for protein redesign

, 2002
The present work focuses on the glutathione transferase (GST) Alpha-class enzymes, their characteristics as steroid isomerases and structural plasticity as malleable scaffolds for protein design. The GSTs are a family of detoxication enzymes that appears
Pettersson, Pär L.
core  

Allosteric Disulfide Bridges in Integrins: The Molecular Switches of Redox Regulation of Integrin-Mediated Cell Functions. [PDF]

Antioxidants (Basel)
Eble JA.
europepmc   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, Volume 40, Issue 7, Page 4676-4709, July 2026.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

Nature's economy as blueprint: regional overlap & block-based algorithm for protein design. [PDF]

Front Bioinform
Retana-Fonseca HA, Damián-Tentle R, Pineda LA, Altamirano-Bustamante MM.   +3 more
europepmc   +1 more source