Results 81 to 90 of about 13,225 (225)

Analyzing the Catalytic Role of Asp97 in the Methionine Aminopeptidase from \u3cem\u3eEscherichia coli\u3c/em\u3e [PDF]

, 2008
An active site aspartate residue, Asp97, in the methionine aminopeptidase (MetAPs) from Escherichia coli (EcMetAP-I) was mutated to alanine, glutamate, and asparagine.
Bennett, Brian, Holz, Richard C., Job, Kathleen M., Meng, Lu, Mitra, Sanghamitra   +4 more
core   +1 more source

Genetic susceptibility to feline infectious peritonitis in Birman cats. [PDF]

, 2013
Genetic factors are presumed to influence the incidence of feline infectious peritonitis (FIP), especially among pedigreed cats. However, proof for the existence of such factors has been limited and mainly anecdotal.
Golovko, Lyudmila, Liu, Hongwei, Lyons, Leslie A, Pedersen, Niels C, Sørensen, Anne, Wehnert, Suzanne   +5 more
core   +1 more source

Interferon Regulatory Factor 2 (IRF2) Suppression Enhances Murine Cardiac Allograft Survival Through Immune Evasion

Immunology, Volume 177, Issue 4, Page 752-765, April 2026.
Our data show that suppressing IRF2, genetically or by siRNA, modulates PD‐L1 and MHC‐I levels. This induced immune‐evasive state critically underlies the significantly prolonged survival of cardiac allografts, revealing a novel therapeutic avenue.
Li Tian, Man Zhang, Yuliang Guo, Sheng Chang, Zhonghua Klaus Chen, Hongmin Zhou   +5 more
wiley   +1 more source

Prognostic Value of Preoperative Serum Leucine Aminopeptidases in Hepatocellular Carcinoma Patients Who Underwent Liver Transplantation

Cancer Management and Research, 2021
Qingqi Ren,1,* Shunjun Fu,2,* Dongping Wang,3– 5 Weiqiang Ju,3– 5 Xiaoshun He3– 5 1Department of Hepatobiliary and Pancreatic Surgery, Peking University Shenzhen Hospital, Shenzhen, People’s Republic of China; 2Department of ...
Ren Q, Fu S, Wang D, Ju W, He X
doaj  

Positional proteomics reveals differences in N-terminal proteoform stability [PDF]

, 2016
To understand the impact of alternative translation initiation on a proteome, we performed a proteome-wide study on protein turnover using positional proteomics and ribosome profiling to distinguish between N-terminal proteoforms of individual genes.
Brown JL, Daria Gawron, Elvis Ndah, Kris Gevaert, Petra Van Damme   +4 more
core   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, Volume 600, Issue 5, Page 631-643, March 2026.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Mutation of H63 and its Catalytic Affect on the Methionine Aminopeptidase from \u3cem\u3eEscherichia coli\u3c/em\u3e [PDF]

, 2009
In order to gain insight into the mechanistic role of a flexible exterior loop near the active site, made up of Y62, H63, G64, and Y65, that has been proposed to play an important role in substrate binding and recognition in the methionyl aminopeptidase ...
Bennett, Brian, Holz, Richard C., Mitra, Sanghamitra   +2 more
core   +2 more sources

The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria [PDF]

, 2012
Malaria remains a significant risk in many areas of the world, with resistance to the current antimalarial pharmacopeia an everincreasing problem. The M1 alanine aminopeptidase (PfM1AAP) and M17 leucine aminopeptidase (PfM17LAP) are believed to play a ...
Christopher L. Brown, Christopher L. Peatey, Colin Stack, Dalal, David Krige, Desire M. M. Nsangou, Dev, Donald L. Gardiner, Enserink, Ersmark, Friesner, Gardiner, Gavigan, Greenwood, Grembecka, Halgren, Harbut, Ichinose, John P. Dalton, Karen Anderson, Karine Thivierge, Katharine R. Trenholme, Krige, Lew, Li, Li, Lowenberg, Luksch, Marks, McGowan, McGowan, Mugittu, Noedl, Nosten, Nwaka, Park, Peters, Rency T. Mathews, Rogers, Rosenthal, Schlitzer, Shelley, Skinner-Adams, Skinner-Adams, Stack, Tina S. Skinner-Adams, Trager, Uhlemann   +47 more
core   +2 more sources

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, Volume 15, Issue 10, 13 March 2026.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros.

PLoS Neglected Tropical Diseases, 2010
BackgroundSnake bite is a major neglected public health issue within poor communities living in the rural areas of several countries throughout the world. An estimated 2.5 million people are bitten by snakes each year and the cost and lack of efficacy of
Sakthivel Vaiyapuri, Simon C Wagstaff, Kimberley A Watson, Robert A Harrison, Jonathan M Gibbins, E Gail Hutchinson   +5 more
doaj   +1 more source