Synthesis of New 4-Aminoquinolines and Evaluation of Their In Vitro Activity against Chloroquine-Sensitive and Chloroquine-Resistant Plasmodium falciparum. [PDF]
PLoS ONE, 2015 The efficacy of chloroquine, once the drug of choice in the fight against Plasmodium falciparum, is now severely limited due to widespread resistance.
Chandima S K Rajapakse +7 more
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4-Aminoquinoline: a comprehensive review of synthetic strategies [PDF]
Frontiers in Chemistry4-Aminoquinoline is an important scaffold due to its variety of applications in medicinal, synthetic organic, and industrial chemistry. It has gained great relevance for the development of selective and potent leishmanicidal agents targeting parasite ...
Francisco Delgado +4 more
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4-Aminoquinolines block heme iron reactivity and interfere with artemisinin action [PDF]
eLifeArtemisinin-based combination therapies (ACTs) remain the mainstay of treatment for Plasmodium falciparum malaria, despite reports of ACT treatment failure. ACTs consist of an artemisinin and a longer-lived partner drug, which is often a quinoline. Given
Melissa Rosenthal, Daniel E Goldberg
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Homology modeling, docking, and ADMET studies of benzoheterocyclic 4-aminoquinolines analogs as inhibitors of Plasmodium falciparum [PDF]
Journal of Taibah University Medical Sciences, 2023 الملخص: أهداف البحث: يتم ضمان الكفاح المستمر ضد الأمراض المستوطنة من خلال مقاومة طفيل الملاريا المتزايدة للأدوية المتاحة على نطاق واسع. وهكذا، فإن البحث عن الأدوية المضادة للملاريا ذات الفعالية المحسنة يتحول إلى بحث دائم.
Zakari Y. Ibrahim, MSc +4 more
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2-Azidobenzaldehyde-Based [4+2] Annulation for the Synthesis of Quinoline Derivatives [PDF]
MoleculesQuinoline is a privileged heterocyclic ring which can be found in many drug molecules and bioactive compounds. The development of synthetic methods for making quinoline derivatives continuously attracts the interest of organic and medicinal chemists ...
Xiaofeng Zhang +3 more
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4-Aminoquinoline as a privileged scaffold for the design of leishmanicidal agents: structure–property relationships and key biological targets [PDF]
Frontiers in ChemistryLeishmaniasis is one of the most important neglected tropical diseases, with more than two million new cases annually. It is endemic in several regions worldwide, representing a public health problem for more than 88 countries, in particular in the ...
Angel H. Romero, Francisco Delgado
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The role of anti-malarial drugs in eliminating malaria [PDF]
Malaria Journal, 2008 Effective anti-malarial drug treatment reduces malaria transmission. This alone can reduce the incidence and prevalence of malaria, although the effects are greater in areas of low transmission where a greater proportion of the infectious reservoir is ...
White Nicholas J
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Genetic analysis and molecular basis of G6PD deficiency among malaria patients in Thailand: implications for safe use of 8-aminoquinolines [PDF]
Malaria JournalBackground It was hypothesized that glucose-6-phosphate dehydrogenase (G6PD) deficiency confers a protective effect against malaria infection, however, safety concerns have been raised regarding haemolytic toxicity caused by radical cure with 8 ...
Usa Boonyuen +13 more
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Long-chain 4-aminoquinolines inhibit filamentation and increase efficacy of nystatin against Candida albicans infections in vivo [PDF]
npj Biofilms and MicrobiomesIn exploring a growing demand for innovative approaches to tackle emerging and life threatening fungal diseases, we identified long-chain 4-aminoquinoline (4-AQ) derivatives as a new class of anti-virulence agents.
Aleksandar Pavic +5 more
doaj +2 more sources
New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria [PDF]
Journal of the Serbian Chemical Society, 2021 Synthesis of novel aminoquinoline derivatives has been accomplished and their activity against malaria strains has been examined. The compounds showed moderate in vitro antimalarial activity against two P.
Opsenica Igor +7 more
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