Results 41 to 50 of about 6,032 (181)

4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease

Pharmaceutics, 2022
Considering that acetylcholinesterase (AChE) inhibition is the most important mode of action expected of a potential drug used for the treatment of symptoms of Alzheimer’s disease (AD), our previous pilot study of 4-aminoquinolines as potential human ...
Katarina Komatović, Ana Matošević, Nataša Terzić-Jovanović, Suzana Žunec, Sandra Šegan, Mario Zlatović, Nikola Maraković, Anita Bosak, Dejan M. Opsenica   +8 more
doaj   +1 more source

Enantioselective Interactions of Anti-Infective 8-Aminoquinoline Therapeutics with Human Monoamine Oxidases A and B

Pharmaceuticals, 2021
8-Aminoquinolines (8-AQs) are an important class of anti-infective therapeutics. The monoamine oxidases (MAOs) play a key role in metabolism of 8-AQs. A major role for MAO-A in metabolism of primaquine (PQ), the prototypical 8-AQ antimalarial, has been ...
Narayan D. Chaurasiya, Haining Liu, Robert J. Doerksen, N. P. Dhammika Nanayakkara, Larry A. Walker, Babu L. Tekwani   +5 more
doaj   +1 more source

Acantholytic pityriasis rubra pilaris associated with topical use of imiquimod 5%: case report and literature review, [PDF]

Anais Brasileiros de Dermatologia, 2020
Topical use of immune response modifiers, such as imiquimod, has increased in dermatology. Although its topical use is well tolerated, it may be associated with exacerbations of generalized cutaneous inflammatory diseases, possibly through the systemic ...
Oriete Gerin Leite, Sandra Tagliolatto, Elemir Macedo de Souza, Maria Letícia Cintra   +3 more
doaj   +1 more source

Antimalarial and antimicrobial activities of 8-aminoquinoline-uracils metal complexes [PDF]

, 2016
8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and ...
Kunwittaya, Sarun, Phopin, Kamonrat, Prachayasittikul, Supaluk, Prachayasittikul, Virapong, Ruchirawat, Somsak, Sinthupoom, Nujarin, Treeratanapiboon, Lertyot   +6 more
core   +1 more source

8-Aminoquinoline Therapy for Latent Malaria [PDF]

Clinical Microbiology Reviews, 2019
The technical genesis and practice of 8-aminoquinoline therapy of latent malaria offer singular scientific, clinical, and public health insights. The 8-aminoquinolines brought revolutionary scientific discoveries, dogmatic practices, benign neglect, and, finally, enduring promise against endemic malaria.
openaire   +2 more sources

Scalable Preparation and Differential Pharmacologic and Toxicologic Profiles of Primaquine Enantiomers [PDF]

, 2016
Hematotoxicity in individuals genetically deficient in glucose-6-phosphate dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only antimalarial drug in clinical use for treatment of relapsing Plasmodium vivax malaria.
Bandara Herath, H. M. T., Baresel, Paul, Bartlett, Marilyn S., Dhammika Nanayakkara, N. P., Fronczek, Frank R., Gettayacamin, Montip, McChesney, James D., Melendez, Victor, Ohrt, Colin, Reichard, Gregory A., Rochford, Rosemary, Sahu, Rajnish, Tekwani, Babu L., Tungtaeng, Anchalee, Van Gessel, Yvonne, Walker, Larry A., Wickham, Kristina S.   +16 more
core   +1 more source

Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines [PDF]

, 2015
We have synthesized a series of dimers of (+)-(7R,11R)-huprine Y and evaluated their activity against Trypanosoma brucei, Plasmodium falciparum, rat myoblast L6 cells and human acetylcholinesterase (hAChE), and their brain permeability.
Artigas, Albert, Clos, Victòria, Gbedema, Stephen Y., Kelly, John M., Muñoz-Torrero López-Ibarra, Diego, Pérez Fernández, Belén, Sola, Irene, Taylor, Martin C., Wright, Colin W.   +8 more
core   +2 more sources

N -Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents [PDF]

Antimicrobial Agents and Chemotherapy, 2013
ABSTRACT A series of cinnamic acid conjugates of primaquine and chloroquine were evaluated for their in vitro antileishmanial activities. Although primaquine derivatives had modest activity, chloroquine conjugates exhibited potent activity against both promastigotes (50% inhibitory concentration [IC
Vale-Costa, S., Costa-Gouveia, J., Perez, B., Silva, T., Teixeira, C., Gomes, P., Gomes, M. S.   +6 more
openaire   +4 more sources

Copper-promoted C5-selective bromination of 8-aminoquinoline amides with alkyl bromides

Beilstein Journal of Organic Chemistry
An efficient and practical method for the synthesis of C5-brominated 8-aminoquinoline amides via a copper-promoted selective bromination of 8-aminoquinoline amides with alkyl bromides was developed.
Changdong Shao, Chen Ma, Li Li, Jingyi Liu, Yanan Shen, Chen Chen, Qionglin Yang, Tianyi Xu, Zhengsong Hu, Yuhe Kan, Tingting Zhang   +10 more
doaj   +1 more source

Recent developments in 8-aminoquinoline antimalarials [PDF]

, 1984
Malaria is an old scourge of mankind and mention of the disease is found in ancient writings in India, Egypt and China [1]. The clinical symptoms of this disease were described by Hippocrates 400 years before the Christian era [1]. Human population affected by malaria is alarmingly large in tropical regions although in the past the disease was also ...
B K, Bhat, M, Seth, A P, Bhaduri
openaire   +2 more sources