Submicroscopic carriage of Plasmodium falciparum and Plasmodium vivax in a low endemic area in Ethiopia where no parasitaemia was detected by microscopy or rapid diagnostic test. [PDF]
, 2015 BACKGROUND: Motivated by the success in malaria control that was documented over the last decade Ethiopia is aiming at malaria elimination by 2020 in selected districts.
Baidjoe, Amrish +9 more
core +4 more sources
Acta Pharmaceutica, 2014 Novel nineteen compounds based on a 4-aminoquinoline scaffold were designed and synthesized as potential antiproliferative agents. The new compounds were N-substituted at the 4-position by aryl or heteroaryl (1-9), quinolin- 3-yl (10), 2-methylquinolin-3-
Ghorab Mostafa M. +2 more
doaj +1 more source
Wide range of G6PD activities found among ethnic groups of the Chittagong Hill Tracts, Bangladesh.
PLoS Neglected Tropical Diseases, 2020 The proportion of Plasmodium vivax malaria among all malarias is increasing worldwide. Treatment with 8-aminoquinolines remain the only radical cure.
Benedikt Ley +12 more
doaj +1 more source
Macromolecular 4-aminoquinoline compounds as potential antimalarial drugs [PDF]
, 2011 4-Aminoquinolines have a long and successful history as antimalarials as they have provided a number of useful antimalarials. P. falciparum, a causative organism of the most deadly form of human malaria, is generally slow to develop resistance to these ...
Aderibigbe, Atim Blessing
core
In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. [PDF]
, 2004 To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003
Stepniewska, K +16 more
core +2 more sources
Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids [PDF]
, 2020 This is the pre-peer reviewed version of the following article: Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids, which has been published in final form at https://doi.org/10.1002/slct.201903835.
Carda, Miguel +6 more
core +1 more source
G6PD deficiency in malaria endemic areas of Nepal
Malaria Journal, 2020 Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency is currently a threat to malaria elimination due to risk of primaquine-induced haemolysis in G6PD deficient individuals.
Baburam Marasini +21 more
doaj +1 more source
Anti-pneumoscystis carinni activitiy of primaquine imidazolidin-4-ones [PDF]
, 2006 Pneumocystis pneumonia (PCP) is one of the most frequent causes of mortality among HIV-infected patients. Primaquine (PQ) is an antimalarial 8-aminoquinoline effective against PCP when given in combination with clindamycin.
Araújo, Maria João +7 more
core
Saquinavir Inhibits the malaria parasite's chloroquine resistance transporter [PDF]
, 2012 The antiretroviral protease inhibitors (APIs) ritonavir, saquinavir, and lopinavir, used to treat HIV infection, inhibit the growth of Plasmodium falciparum at clinically relevant concentrations.
Alice S. Butterworth +43 more
core +1 more source
8-Amino-6-Methoxyquinoline—Tetrazole Hybrids: Impact of Linkers on Antiplasmodial Activity
Molecules, 2021 A new series of compounds was prepared from 6-methoxyquinolin-8-amine or its N-(2-aminoethyl) analogue via Ugi-azide reaction. Their linkers between the quinoline and the tert-butyltetrazole moieties differ in chain length, basicity and substitution ...
Patrick Hochegger +6 more
doaj +1 more source