Results 81 to 90 of about 6,032 (181)
PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity [PDF]
, 2010 Primacenes, novel ferrocene-primaquine conjugates, were synthesized and screened for their antimalarial and anti-pneumocystis activity. Primacenes obtained by coupling primaquine amino acid derivatives to ferrocenoic acid were significantly active ...
Jiri Gut +7 more
core +1 more source
Antimalarials with Benzothiophene Moieties as Aminoquinoline Partners
Molecules, 2017 Malaria is a severe and life-threatening disease caused by Plasmodium parasites that are spread to humans through bites of infected Anopheles mosquitoes.
Jelena Konstantinović +6 more
doaj +1 more source
Evaluation of α,β-unsaturated ketones as antileishmanial agents [PDF]
, 2015 In this study, we assessed the antileishmanial activity of 126 α,β-unsaturated ketones. The compounds NC901, NC884, and NC2459 showed high leishmanicidal activity for both the extracellular (50% effective concentration [EC(50)], 456 nM, 1,122 nM, and 20 ...
Beverley, Stephen M +6 more
core +2 more sources
PLoS Medicine, 2017 BackgroundRadical cure of Plasmodium vivax malaria with 8-aminoquinolines (primaquine or tafenoquine) is complicated by haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Cindy S Chu +14 more
doaj +1 more source
Terapèutica antiparasitària [PDF]
, 2005 Els paràsits són els més oblidats dels microorganismes patògens. El fet que la seva major prevalença es doni als països de l'àrea tropical, països pobres en la seva major part, potser influeix en aquest fet.
Oliveira, Inés M.
core
Malaria Journal, 2018 Background Tafenoquine was recently approved for Plasmodium vivax radical cure (KRINTAFEL™) and malaria prevention (ARAKODA™). Methods A review of the non-clinical and clinical literature was conducted to assess whether tafenoquine (and primaquine ...
Jonathan Berman +3 more
doaj +1 more source
Cobalt-Catalyzed Direct Carbonylation of Aminoquinoline Benzamides
Organic Letters, 2014 A method for direct carbonylation of aminoquinoline benzamides has been developed. Reactions proceed at room temperature in trifluoroethanol solvent, use oxygen from air as an oxidant, and require Mn(OAc)3 as a cocatalyst. Benzoic and acrylic acid derivatives can be carbonylated by carbon monoxide affording imides in good yields. Halogen, nitro, ether,
Grigorjeva, Liene, Daugulis, Olafs
openaire +2 more sources
Plant-derived antimalarial agents: from crude extracts to isolated bioactive compounds [PDF]
, 2011 Despite decades of intense research, malaria remains a deadly disease of the developing worlds. Drugresistance to limited available antimalarials, in part, has contributed to the persistence of this infectious disease.
Abdullah, Wan Omar, Ismail, Patimah
core
Malaria and the traveller [PDF]
, 2005 Malaria has reached epidemic proportions. About 40% of the world’s population live in malarious areas. It is estimated that 400 million people are infected by malaria each year and of these, 1-3 million die, mostly children under five years of age.
Tonna, Antonella, Tonna, Ivan
core
Universitas Scientiarum, 2012 To study the toxicological properties of three hybrid compounds, quinoline-thiazolidinone (FR-72 and FR-121) and acridin-epoxyisoindolindione (FR- 154), applying named compounds to the test of the roots of Allium cepa onion bulbs.
Ricardo Restrepo Manrique +4 more
doaj