Results 11 to 20 of about 118,015 (300)

Composition and Technology Development for Obtaining Amorphous Solid Dispersion of Ebastine by Hot Melt Extrusion to Increase Dissolution Rate

Разработка и регистрация лекарственных средств, 2023
Introduction. Ebastine is a second-generation antihistamine drug available in the form of orally disintegrating tablets and film-coated tablets. Ebastine substance exhibits high bioavailability, but low solubility in water and gastrointestinal tract ...
K. A. Gusev, A. R. Aliev, Yu. E. Generalova, N. A. Aksenova, G. V. Rechkalov, D. N. Maimistov, G. M. Alekseeva, E. V. Flisyuk   +7 more
doaj   +1 more source

Selecting the most appropriate formulation excipient for manufacture of amorphous solid dispersions: a case study of lumefantrine

British Journal of Pharmacy, 2022
This work demonstrated the importance of pre-formulation studies and proposed a generalised scheme for excipient screening in the early stage of amorphous solid dispersion(ASD) system development by profiling the excipients’ capability to solubilise ...
Dijia Liu, Shu Li, David Jones, Gavin Paul Andrews   +3 more
doaj   +1 more source

3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and drop-on-powder printing

International Journal of Pharmaceutics: X, 2023
Nowadays, a high number of pipeline drugs are poorly soluble and require solubility enhancement by e.g., manufacturing of amorphous solid dispersion. Pharmaceutical 3D printing has great potential in producing amorphous solid oral dosage forms.
Nadine Gottschalk, Malte Bogdahn, Julian Quodbach   +2 more
doaj   +1 more source

Tailoring supersaturation from amorphous solid dispersions [PDF]

Journal of Controlled Release, 2018
The maximum achievable concentration of a drug in solution is dictated by the chemical potential of the solid form. Because an amorphous solid has a higher chemical potential than the corresponding crystal form, in the absence of phase transformations, a higher transient solubility is expected.
Na Li, Lynne S. Taylor
openaire   +2 more sources

Enhancing therapeutic potential of poor aqueous soluble herbal drugs through solid dispersion-An overview

Phytomedicine Plus, 2021
Background: Poorly water-soluble medicaments continue to be a challenging, however, significant class of herbal drugs for the management of an extensive range of ailments.
Shahid Ud Din Wani, Vasundhra Kakkar, Surya Prakash Gautam, Gangadharappa HV, Mohammad Ali, Mubashir Hussain Masoodi, Afrasim Moin   +6 more
doaj   +1 more source

Applicability of an Experimental Grade of Hydroxypropyl Methylcellulose Acetate Succinate as a Carrier for Formation of Solid Dispersion with Indomethacin

Pharmaceutics, 2021
The transformation of a crystalline drug into an amorphous form is a promising way to enhance the oral bioavailability of poorly water-soluble drugs. Blending of a carrier, such as a hydrophilic polymer, with an amorphous drug is a widely used method to ...
Hiroshi Ueda, Yuya Hirakawa, Hironori Tanaka, Tetsuya Miyano, Katsuji Sugita   +4 more
doaj   +1 more source

Polymer/Amorphous Salt Solid Dispersions of Ciprofloxacin [PDF]

Pharmaceutical Research, 2017
To improve the pharmaceutical properties of amorphous ciprofloxacin (CIP) succinate salts via formulation as polymer/amorphous salt solid dispersions (ASSDs).ASSDs consisting of an amorphous CIP/succinic acid 1:1 or 2:1 salt dispersed in PVP or Soluplus were produced by spray drying and ball milling.
Hanah Mesallati, Lidia Tajber
openaire   +4 more sources

Enhanced Oral Bioavailability of Resveratrol by Using Neutralized Eudragit E Solid Dispersion Prepared via Spray Drying

Antioxidants, 2021
In this study, we designed amorphous solid dispersions based on Eudragit E/HCl (neutralized Eudragit E using hydrochloric acid) to maximize the dissolution of trans-resveratrol.
Eun-Sol Ha, Du Hyung Choi, In-hwan Baek, Heejun Park, Min-Soo Kim   +4 more
doaj   +1 more source

Preparation and Characterization of Carvedilol Solid Dispersion by Kneading Method

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2023
Solid dispersion using hydrophilic carrier is one of the approaches that has a potential to increase solubility, dissolution rate and consequently the oral bioavailability of poorly-water soluble drugs.
Ali Q. Hatem, Wedad K. Ali
doaj   +1 more source

The Stabilization of Amorphous Zopiclone in an Amorphous Solid Dispersion [PDF]

AAPS PharmSciTech, 2015
Zopiclone is a poorly soluble psychotherapeutic agent. The aim of this study was to prepare and characterize an amorphous form of zopiclone as well as the characterization and performance of a stable amorphous solid dispersion. The amorphous form was prepared by the well-known method of quench-cooling of the melt. The solid dispersion was prepared by a
Milne, Marnus, Liebenberg, Wilna, Aucamp, Marique   +2 more
openaire   +4 more sources