Results 31 to 40 of about 2,340,313 (291)
Use of Solid Dispersion Systems in Pharmacy
Конденсированные среды и межфазные границы, 2020 An overview of the use of solid dispersion systems in pharmacy is presented. The main techniques of obtaining solid dispersions were considered. The simplest one is the solvent removal technique: the medicinal drug and the carrier are dissolved in the ...
Sof ’ya Yu. Silaeva +6 more
doaj +1 more source
Asian Journal of Pharmaceutical Sciences, 2015 Solid dispersion is one of the most promising strategies to improve oral bioavailability of poorly soluble API. However, there are inconsistent dissolution performances of solid dispersion reported which entails further investigation.
Siok-Yee Chan +4 more
doaj +1 more source
Highly Porous and Drug-Loaded Amorphous Solid Dispersion Microfiber Scaffolds of Indomethacin Prepared by Melt Electrowriting [PDF]
, 2022 Melt electrowriting (MEW) is an additive manufacturing technology enabling the production of highly porous microfiber scaffolds, suggested in particular for use in biomedical applications, including drug delivery.
Juliane C., Kade +15 more
core +2 more sources
Tailoring supersaturation from amorphous solid dispersions [PDF]
Journal of Controlled Release, 2018 The maximum achievable concentration of a drug in solution is dictated by the chemical potential of the solid form. Because an amorphous solid has a higher chemical potential than the corresponding crystal form, in the absence of phase transformations, a higher transient solubility is expected.
Na Li, Lynne S. Taylor
openaire +2 more sources
Pharmaceutics, 2020 This study aimed to improve the solubility and dissolution of aprepitant, a drug with poor aqueous solubility, using a phosphatidylcholine (PC)-based solid dispersion system.
Sooho Yeo +4 more
doaj +1 more source
Mesoporous Silica as a Carrier for Amorphous Solid Dispersion [PDF]
, 2017 In the past decade, the discovery of active pharmaceutical substances with high therapeutic value but poor aqueous solubility has increased, thus making it challenging to formulate these compounds as oral dosage forms.
Anshul Gupte, Smruti P. Chaudhari
core +1 more source
Solid Dispersion Technology for Improving the Solubility of Antiviral Drugs
Pharmaceutical Sciences and Research, 2023 Most drugs, including antiviral drugs, show low solubility in water, which affects dissolution, bioavailability, and therapeutic effectiveness. Therefore, many antiviral drugs are given in very large doses.
Maria Elvina Tresia Butar-Butar +3 more
doaj +1 more source
Advances in Pharmacological and Pharmaceutical Sciences, 2023 Amorphous salt solid dispersion (ASSD) of Dolutegravir amorphous salt (DSSD) was generated using quench cooling and compared to its Dolutegravir free acid solid dispersion (DFSD) to improve the solubility and bioavailability. Soluplus (SLP) was used as a
Dani Lakshman Yarlagadda +3 more
doaj +1 more source
Modelling phase separation in amorphous solid dispersions [PDF]
Acta Biomaterialia, 2019 Much work has been devoted to analysing thermodynamic models for solid dispersions with a view to identifying regions in the phase diagram where amorphous phase separation or drug recrystallization can occur. However, detailed partial differential equation non-equilibrium models that track the evolution of solid dispersions in time and space are ...
Meere Martin +2 more
openaire +5 more sources
Indonesian Journal of Chemistry, 2023 Carvedilol (CVD) is a non-selective β-blocker. CVD is included in BCS class II. It has low water solubility. In this research, solid dispersion was used to increase the solubility and dissolution profile of CVD.
Iyan Sopyan +3 more
doaj +1 more source