Results 31 to 40 of about 30,050 (289)

The amorphous solid dispersion of the poorly soluble ABT-102 forms nano/microparticulate structures in aqueous medium: impact on solubility

International Journal of Nanomedicine, 2012
Kerstin J Frank,1,3 Ulrich Westedt,2 Karin M Rosenblatt,2 Peter Hölig,2 Jörg Rosenberg,2 Markus Mägerlein,2 Gert Fricker,3 Martin Brandl11Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense ...
Frank KJ, Westedt U, Rosenblatt KM, Hölig P, Rosenberg J, Mägerlein M, Fricker G, Brandl M   +7 more
doaj   +1 more source

Enhancing the dissolution rate of poorly soluble drug Febuxostat using spray dried amorphous solid dispersion technique

Ars Pharmaceutica, 2023
Introduction: Febuxostat belongs to Biopharmaceutical classification system (BCS) class II drugs, which have low solubility and high permeability. Amorphous solid dispersion is one of the techniques which can be useful to improve solubility and powder ...
Vaishali Patel, Anita Patel, Ashish Shah
doaj   +1 more source

Selecting the most appropriate formulation excipient for manufacture of amorphous solid dispersions: a case study of lumefantrine

British Journal of Pharmacy, 2022
This work demonstrated the importance of pre-formulation studies and proposed a generalised scheme for excipient screening in the early stage of amorphous solid dispersion(ASD) system development by profiling the excipients’ capability to solubilise ...
Dijia Liu, Shu Li, David Jones, Gavin Paul Andrews   +3 more
doaj   +1 more source

3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and drop-on-powder printing

International Journal of Pharmaceutics: X, 2023
Nowadays, a high number of pipeline drugs are poorly soluble and require solubility enhancement by e.g., manufacturing of amorphous solid dispersion. Pharmaceutical 3D printing has great potential in producing amorphous solid oral dosage forms.
Nadine Gottschalk, Malte Bogdahn, Julian Quodbach   +2 more
doaj   +1 more source

Enhancing therapeutic potential of poor aqueous soluble herbal drugs through solid dispersion-An overview

Phytomedicine Plus, 2021
Background: Poorly water-soluble medicaments continue to be a challenging, however, significant class of herbal drugs for the management of an extensive range of ailments.
Shahid Ud Din Wani, Vasundhra Kakkar, Surya Prakash Gautam, Gangadharappa HV, Mohammad Ali, Mubashir Hussain Masoodi, Afrasim Moin   +6 more
doaj   +1 more source

Polymer/Amorphous Salt Solid Dispersions of Ciprofloxacin [PDF]

Pharmaceutical Research, 2017
To improve the pharmaceutical properties of amorphous ciprofloxacin (CIP) succinate salts via formulation as polymer/amorphous salt solid dispersions (ASSDs).ASSDs consisting of an amorphous CIP/succinic acid 1:1 or 2:1 salt dispersed in PVP or Soluplus were produced by spray drying and ball milling.
Hanah Mesallati, Lidia Tajber
openaire   +4 more sources

Highly Porous and Drug-Loaded Amorphous Solid Dispersion Microfiber Scaffolds of Indomethacin Prepared by Melt Electrowriting [PDF]

, 2022
Melt electrowriting (MEW) is an additive manufacturing technology enabling the production of highly porous microfiber scaffolds, suggested in particular for use in biomedical applications, including drug delivery.
Juliane C., Kade, Kade, Juliane C., Kessler, Larissa, Larissa, Keßler, Larissa Keßler (4849357), Juliane C. Kade, Zeynab, Mirzaei, Juliane C. Kade (14321816), Robert, Luxenhofer, Larissa Keßler, Mirzaei, Zeynab, Zeynab Mirzaei (14321813), Robert Luxenhofer (2006884), Zeynab Mirzaei, Robert Luxenhofer, Luxenhofer, Robert   +15 more
core   +1 more source

Applicability of an Experimental Grade of Hydroxypropyl Methylcellulose Acetate Succinate as a Carrier for Formation of Solid Dispersion with Indomethacin

Pharmaceutics, 2021
The transformation of a crystalline drug into an amorphous form is a promising way to enhance the oral bioavailability of poorly water-soluble drugs. Blending of a carrier, such as a hydrophilic polymer, with an amorphous drug is a widely used method to ...
Hiroshi Ueda, Yuya Hirakawa, Hironori Tanaka, Tetsuya Miyano, Katsuji Sugita   +4 more
doaj   +1 more source

Enhanced Oral Bioavailability of Resveratrol by Using Neutralized Eudragit E Solid Dispersion Prepared via Spray Drying

Antioxidants, 2021
In this study, we designed amorphous solid dispersions based on Eudragit E/HCl (neutralized Eudragit E using hydrochloric acid) to maximize the dissolution of trans-resveratrol.
Eun-Sol Ha, Du Hyung Choi, In-hwan Baek, Heejun Park, Min-Soo Kim   +4 more
doaj   +1 more source

Advancing Drug Delivery Paradigms: Polyvinyl Pyrolidone (PVP)-Based Amorphous Solid Dispersion for Enhanced Physicochemical Properties and Therapeutic Efficacy [PDF]

Polymers
Amirah Mohd Gazzali, Sandra Megantara, Diah Lia Aulifa   +2 more
exaly   +2 more sources