Results 51 to 60 of about 30,050 (289)
Indonesian Journal of Chemistry, 2023 Carvedilol (CVD) is a non-selective β-blocker. CVD is included in BCS class II. It has low water solubility. In this research, solid dispersion was used to increase the solubility and dissolution profile of CVD.
Iyan Sopyan +3 more
doaj +1 more source
Whey proteins as stabilizers in amorphous solid dispersions
European Journal of Pharmaceutical Sciences, 2019 Whey proteins are extensively used as nutritional supplements but have so far not been investigated as co-formers for amorphous solid dispersions (ASD) to enhance the solubility and dissolution rate of poorly water soluble drugs. In this study, whey protein isolate (WPI) and whey protein hydrolysate (WPH) were each mixed with three poorly water soluble
Jaya Mishra +4 more
openaire +3 more sources
Mesoporous Silica as a Carrier for Amorphous Solid Dispersion [PDF]
, 2017 In the past decade, the discovery of active pharmaceutical substances with high therapeutic value but poor aqueous solubility has increased, thus making it challenging to formulate these compounds as oral dosage forms.
Anshul Gupte, Smruti P. Chaudhari
core +1 more source
Triboelectrification and dissolution property enhancements of solid dispersions
, 2015 The use of solid dispersion techniques to modify physicochemical properties and improve solubility and dissolution rate may result in alteration to electrostatic properties of particles.
Conway, Barbara R +12 more
core +1 more source
Spray drying formulation of amorphous solid dispersions
Advanced Drug Delivery Reviews, 2016 Spray drying is a well-established manufacturing technique which can be used to formulate amorphous solid dispersions (ASDs) which is an effective strategy to deliver poorly water soluble drugs (PWSDs). However, the inherently complex nature of the spray drying process coupled with specific characteristics of ASDs makes it an interesting area to ...
Singh, Abhishek, Van den Mooter, Guy
openaire +4 more sources
Pharmaceuticals, 2023 Fenretinide (4-HPR), a retinoid derivative, has shown high antitumor activity, a low toxicological profile, and no induction of resistance. Despite these favorable features, the variability in oral absorption due to its low solubility combined with the high hepatic first pass effect strongly reduce clinical outcomes.
Guendalina Zuccari +6 more
openaire +3 more sources
Journal of Advanced Pharmaceutical Technology & Research, 2016 The aim of this research is to prepare and characterize solid dispersion of efavirenz – polyvinylpyrrolidone (PVP) K-30 by freeze drying to increase its solubility.
Lili Fitriani +2 more
doaj +1 more source
ADMET and DMPK, 2023 Introduction: Olanzapine (OLZ) is a psychotropic class drug commonly used to treat schizophrenia, bipolar disorder, and acute manic episodes. It has less water solubility, resulting in a slow dissolution rate and oral bioavailability.
Leena Patil +5 more
doaj +1 more source
Effect of molecular interactions on properties of amorphous solid dispersions
, 2021 Amorphous solid dispersions have been widely applied to improve the oral bioavailability of BCS Class II and Class IV compounds by increasing their kinetic solubility and dissolution rate.
Meng, Fan
core +1 more source
Advanced Engineering Materials, Volume 27, Issue 6, March 2025.ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur +5 more
wiley +1 more source