Results 41 to 50 of about 2,340,313 (291)
Molecules, 2021 Fused deposition modelling-based 3D printing of pharmaceutical products is facing challenges like brittleness and printability of the drug-loaded hot-melt extruded filament feedstock and stabilization of the solid-state form of the drug in the final ...
Eric Ofosu Kissi +4 more
doaj +1 more source
Amorphous Solid Dispersion Tablets Overcome Acalabrutinib pH Effect in Dogs
Pharmaceutics, 2021 Calquence® (crystalline acalabrutinib), a commercially marketed tyrosine kinase inhibitor (TKI), exhibits significantly reduced oral exposure when taken with acid-reducing agents (ARAs) due to the low solubility of the weakly basic drug at elevated ...
Deanna M. Mudie +8 more
doaj +1 more source
Solid-state characterization of Felodipine–Soluplus amorphous solid dispersions [PDF]
Drug Development and Industrial Pharmacy, 2015 The aim of the current study is to develop amorphous solid dispersion (SD) via hot melt extrusion technology to improve the solubility of a water-insoluble compound, felodipine (FEL). The solubility was dramatically increased by preparation of amorphous SDs via hot-melt extrusion with an amphiphilic polymer, Soluplus® (SOL).
Jiannan, Lu +7 more
openaire +2 more sources
Nature of the amorphous-amorphous interfaces in solid-state batteries revealed using machine-learned interatomic potentials [PDF]
, 2023 Non-crystalline solid materials have attracted growing attention in energy storage for their desirable properties such as ionic conductivity, stability and processability.
Tim , Mueller +2 more
core +1 more source
Journal of Advanced Pharmaceutical Technology & Research, 2016 The aim of this research is to prepare and characterize solid dispersion of efavirenz – polyvinylpyrrolidone (PVP) K-30 by freeze drying to increase its solubility.
Lili Fitriani +2 more
doaj +1 more source
ADMET and DMPK, 2023 Introduction: Olanzapine (OLZ) is a psychotropic class drug commonly used to treat schizophrenia, bipolar disorder, and acute manic episodes. It has less water solubility, resulting in a slow dissolution rate and oral bioavailability.
Leena Patil +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Advanced Engineering Materials, Volume 27, Issue 6, March 2025.ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur +5 more
wiley +1 more source
Selection of Solubility Enhancement Technologies for S-892216, a Novel COVID-19 Drug Candidate
PharmaceuticsBackground/Objectives: S-892216 is a poorly water-soluble drug developed as a novel oral treatment for COVID-19, although its oral absorption is low. For Phase 1 (Ph1) studies and commercial use, both oral solution and solid dispersion technologies are ...
Ryo Ohashi +7 more
doaj +1 more source
Advanced Engineering Materials, Volume 27, Issue 6, March 2025.The stability criteria affecting the formation of high‐entropy alloys, particularly focusing in supersaturated solid solutions produced by mechanical alloying, are analyzed. Criteria based on Hume–Rothery rules are distinguished from those derived from thermodynamic relations. The formers are generally applicable to mechanically alloyed samples.
Javier S. Blázquez +5 more
wiley +1 more source