Results 41 to 50 of about 30,050 (289)
Tailoring supersaturation from amorphous solid dispersions [PDF]
Journal of Controlled Release, 2018 The maximum achievable concentration of a drug in solution is dictated by the chemical potential of the solid form. Because an amorphous solid has a higher chemical potential than the corresponding crystal form, in the absence of phase transformations, a higher transient solubility is expected.
Na Li, Lynne S. Taylor
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Modelling phase separation in amorphous solid dispersions [PDF]
Acta Biomaterialia, 2019 Much work has been devoted to analysing thermodynamic models for solid dispersions with a view to identifying regions in the phase diagram where amorphous phase separation or drug recrystallization can occur. However, detailed partial differential equation non-equilibrium models that track the evolution of solid dispersions in time and space are ...
Meere Martin +2 more
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Solid-state characterization of Felodipine–Soluplus amorphous solid dispersions [PDF]
Drug Development and Industrial Pharmacy, 2015 The aim of the current study is to develop amorphous solid dispersion (SD) via hot melt extrusion technology to improve the solubility of a water-insoluble compound, felodipine (FEL). The solubility was dramatically increased by preparation of amorphous SDs via hot-melt extrusion with an amphiphilic polymer, Soluplus® (SOL).
Jiannan, Lu +7 more
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Use of Solid Dispersion Systems in Pharmacy
Конденсированные среды и межфазные границы, 2020 An overview of the use of solid dispersion systems in pharmacy is presented. The main techniques of obtaining solid dispersions were considered. The simplest one is the solvent removal technique: the medicinal drug and the carrier are dissolved in the ...
Sof ’ya Yu. Silaeva +6 more
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Asian Journal of Pharmaceutical Sciences, 2015 Solid dispersion is one of the most promising strategies to improve oral bioavailability of poorly soluble API. However, there are inconsistent dissolution performances of solid dispersion reported which entails further investigation.
Siok-Yee Chan +4 more
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Thermal stability of amorphous sugar matrix, dried from methanol, as an amorphous solid dispersion carrier [PDF]
, 2018 [EN] Developing a technique to disperse hydrophobic ingredients homogeneously in a water-soluble solid matrix (solid dispersion) is one of the topics that have been extensively investigated in the pharmaceutical and food industries.
Takeda, K. +9 more
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Pharmaceutics, 2020 This study aimed to improve the solubility and dissolution of aprepitant, a drug with poor aqueous solubility, using a phosphatidylcholine (PC)-based solid dispersion system.
Sooho Yeo +4 more
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Solid Dispersion Technology for Improving the Solubility of Antiviral Drugs
Pharmaceutical Sciences and Research, 2023 Most drugs, including antiviral drugs, show low solubility in water, which affects dissolution, bioavailability, and therapeutic effectiveness. Therefore, many antiviral drugs are given in very large doses.
Maria Elvina Tresia Butar-Butar +3 more
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Manufacturing strategies to develop amorphous solid dispersions: An overview [PDF]
Journal of Drug Delivery Science and Technology, 2020 Since the past several decades, poor water solubility of existing and new drugs in the pipeline have remained a challenging issue for the pharmaceutical industry. Literature describes several approaches to improve the overall solubility, dissolution rate, and bioavailability of drugs with poor water solubility.
Nicole, Mendonsa +6 more
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Advances in Pharmacological and Pharmaceutical Sciences, 2023 Amorphous salt solid dispersion (ASSD) of Dolutegravir amorphous salt (DSSD) was generated using quench cooling and compared to its Dolutegravir free acid solid dispersion (DFSD) to improve the solubility and bioavailability. Soluplus (SLP) was used as a
Dani Lakshman Yarlagadda +3 more
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