Results 21 to 30 of about 30,050 (289)
Preparation and Characterization of Carvedilol Solid Dispersion by Kneading Method
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2023 Solid dispersion using hydrophilic carrier is one of the approaches that has a potential to increase solubility, dissolution rate and consequently the oral bioavailability of poorly-water soluble drugs.
Ali Q. Hatem, Wedad K. Ali
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Amorphous Solid Dispersion Tablets Overcome Acalabrutinib pH Effect in Dogs [PDF]
Pharmaceutics, 2021 Calquence® (crystalline acalabrutinib), a commercially marketed tyrosine kinase inhibitor (TKI), exhibits significantly reduced oral exposure when taken with acid-reducing agents (ARAs) due to the low solubility of the weakly basic drug at elevated ...
Deanna M. Mudie +8 more
doaj +2 more sources
Pharmaceuticals, 2020 This study aimed to investigate the effect of polymers and storage relative humidity on amorphous rebamipide (RB) and its solid dispersion phase transformation using chemometrics based on multiple datasets.
Yuta Otsuka +5 more
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Drug-excipient behavior in polymeric amorphous solid dispersions [PDF]
Journal of Excipients and Food Chemicals, 2016 Amorphous drug delivery systems are increasingly utilized to enhance aqueous solubility and oral bioavailability. However, they lack physical and/or chemical stability.
Surikutchi Bhanu Teja +4 more
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Preparation and Characterization of Spherical Amorphous Solid Dispersion with Amphotericin B
Pharmaceutics, 2018 In the present study, new polymer microspheres of amphotericin B (AmB) were prepared by a spray drying technique using cyclodextrin polymers (Poly-CD) to improve the solubility and dissolution of AmB, to prevent in vivo toxic AmB aggregations ...
Lyes Mehenni +4 more
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Influence of Drug Load on the Printability and Solid-State Properties of 3D-Printed Naproxen-Based Amorphous Solid Dispersion [PDF]
Molecules, 2021 Fused deposition modelling-based 3D printing of pharmaceutical products is facing challenges like brittleness and printability of the drug-loaded hot-melt extruded filament feedstock and stabilization of the solid-state form of the drug in the final ...
Eric Ofosu Kissi +4 more
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Biopharmaceutical Study on Nobiletin-Loaded Amorphous Solid Dispersion with Improved Hypouricemic Effect [PDF]
Molecules, 2021 The present study aimed to develop an amorphous solid dispersion of nobiletin (ASD/NOB) using hydroxypropyl cellulose-SSL (HPC-SSL) to improve the pharmacokinetic properties and hypouricemic effect of NOB. ASD/NOB was prepared by the freeze-drying method
Takuya Nihei +3 more
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Pharmaceutics, 2018 In order to improve the aqueous solubility and dissolution of Tacrolimus (TAC), amorphous solid dispersions of TAC were prepared by hot melt extrusion with three hydrophilic polymers, Polyvinylpyrrolidone vinyl acetate (PVP VA64), Soluplus® and ...
Poovizhi Ponnammal +4 more
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Delivery of Poorly Soluble Compounds by Amorphous Solid Dispersions
Current Pharmaceutical Design, 2014 Solid state manipulation by amorphous solid dispersion has been the subject of intensive research for decades due to their excellent potential for dissolution and bioavailability enhancement. The present review aims to highlight the latest advancement in this area, with focus on the fundamentals, characterization, formulation development and ...
Chow, Albert H.L. +5 more
openaire +5 more sources
Drug Design, Development and Therapy, 2015 Xuezhi Yin,1,3 Linda Sharon Daintree,2 Sheng Ding,3 Daniel Mark Ledger,2 Bing Wang,3 Wenwen Zhao,2 Jianping Qi,1 Wei Wu1 1Department of Pharmaceutics, School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery of Ministry of Education ...
Yin X +7 more
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