Results 21 to 30 of about 2,340,313 (291)

3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and drop-on-powder printing

International Journal of Pharmaceutics: X, 2023
Nowadays, a high number of pipeline drugs are poorly soluble and require solubility enhancement by e.g., manufacturing of amorphous solid dispersion. Pharmaceutical 3D printing has great potential in producing amorphous solid oral dosage forms.
Nadine Gottschalk, Malte Bogdahn, Julian Quodbach   +2 more
doaj   +1 more source

Enhancing therapeutic potential of poor aqueous soluble herbal drugs through solid dispersion-An overview

Phytomedicine Plus, 2021
Background: Poorly water-soluble medicaments continue to be a challenging, however, significant class of herbal drugs for the management of an extensive range of ailments.
Shahid Ud Din Wani, Vasundhra Kakkar, Surya Prakash Gautam, Gangadharappa HV, Mohammad Ali, Mubashir Hussain Masoodi, Afrasim Moin   +6 more
doaj   +1 more source

Applicability of an Experimental Grade of Hydroxypropyl Methylcellulose Acetate Succinate as a Carrier for Formation of Solid Dispersion with Indomethacin

Pharmaceutics, 2021
The transformation of a crystalline drug into an amorphous form is a promising way to enhance the oral bioavailability of poorly water-soluble drugs. Blending of a carrier, such as a hydrophilic polymer, with an amorphous drug is a widely used method to ...
Hiroshi Ueda, Yuya Hirakawa, Hironori Tanaka, Tetsuya Miyano, Katsuji Sugita   +4 more
doaj   +1 more source

Enhanced Oral Bioavailability of Resveratrol by Using Neutralized Eudragit E Solid Dispersion Prepared via Spray Drying

Antioxidants, 2021
In this study, we designed amorphous solid dispersions based on Eudragit E/HCl (neutralized Eudragit E using hydrochloric acid) to maximize the dissolution of trans-resveratrol.
Eun-Sol Ha, Du Hyung Choi, In-hwan Baek, Heejun Park, Min-Soo Kim   +4 more
doaj   +1 more source

Preparation and Characterization of Carvedilol Solid Dispersion by Kneading Method

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2023
Solid dispersion using hydrophilic carrier is one of the approaches that has a potential to increase solubility, dissolution rate and consequently the oral bioavailability of poorly-water soluble drugs.
Ali Q. Hatem, Wedad K. Ali
doaj   +1 more source

Evaluating the effect of the porous and non-porous colloidal silicon dioxide as a stabilizer on amorphous solid dispersion [PDF]

, 2020
Advancement in the discovery of drugs has led to many highly lipophilic compounds with very low water solubility. Amorphous solid dispersion is one of the emerging technologies to increase the solubility of these drugs.
Dave, Rutesh H., Bhadiyadra, Mittal, Chaudhari, Smruti P.   +2 more
core   +1 more source

Effect of Polymers and Storage Relative Humidity on Amorphous Rebamipide and Its Solid Dispersion Transformation: Multiple Spectra Chemometrics of Powder X-Ray Diffraction and Near-Infrared Spectroscopy

Pharmaceuticals, 2020
This study aimed to investigate the effect of polymers and storage relative humidity on amorphous rebamipide (RB) and its solid dispersion phase transformation using chemometrics based on multiple datasets.
Yuta Otsuka, Yuiko Utsunomiya, Daiki Umeda, Etsuo Yonemochi, Yayoi Kawano, Takehisa Hanawa   +5 more
doaj   +1 more source

Polymer/Amorphous Salt Solid Dispersions of Ciprofloxacin [PDF]

Pharmaceutical Research, 2017
To improve the pharmaceutical properties of amorphous ciprofloxacin (CIP) succinate salts via formulation as polymer/amorphous salt solid dispersions (ASSDs).ASSDs consisting of an amorphous CIP/succinic acid 1:1 or 2:1 salt dispersed in PVP or Soluplus were produced by spray drying and ball milling.
Hanah Mesallati, Lidia Tajber
openaire   +4 more sources

Triboelectrification and dissolution property enhancements of solid dispersions [PDF]

, 2015
The use of solid dispersion techniques to modify physicochemical properties and improve solubility and dissolution rate may result in alteration to electrostatic properties of particles.
Conway, Barbara R, Hiba Al-Hamidi (16203491), Šupuk, Enes, Conway, Barbara R., Kofi Asare-Addo (4172488), Al-Hamidi, Hiba, Owusu-Ware, Samuel, Asare-Addo, Kofi, Samuel Owusu-Ware (16228529), Barbara R. Conway (4172491), Enes Šupuk (16228532), Nokhodchi, Ali, Ali Nokhodchi (4465915), Conway, Barbara R.; id_orcid   +13 more
core   +1 more source

Thermal stability of amorphous sugar matrix, dried from methanol, as an amorphous solid dispersion carrier [PDF]

, 2018
[EN] Developing a technique to disperse hydrophobic ingredients homogeneously in a water-soluble solid matrix (solid dispersion) is one of the topics that have been extensively investigated in the pharmaceutical and food industries.
Takeda, K., Imamura, Koreyoshi, Koreyoshi Imamura, Yamamoto, K., H. Imanaka, N. Ishida, Imanaka, H., K. Yamamoto, Ishida, N., K. Takeda   +9 more
core   +1 more source