Results 11 to 20 of about 2,340,313 (291)

Thermal Stability of Amorphous Solid Dispersions [PDF]

Molecules, 2021
Amorphous solid dispersion drug delivery systems (ASD DDS) were proved to be efficient for the enhancement of solubility and bioavailability of poorly water-soluble drugs.
Dijana Jelić
doaj   +4 more sources

The stabilization of amorphous zopiclone in an amorphous solid dispersion [PDF]

AAPS PharmSciTech, 2015
Zopiclone is a poorly soluble psychotherapeutic agent. The aim of this study was to prepare and characterize an amorphous form of zopiclone as well as the characterization and performance of a stable amorphous solid dispersion.
Milne, Marnus, Aucamp, Marique, Liebenberg, Wilna   +2 more
core   +5 more sources

Cellulose based polymers in development of amorphous solid dispersions

Asian Journal of Pharmaceutical Sciences, 2019
Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of ...
Rahul B Chavan, Sneha Rathi, Vaskuri G S Sainaga Jyothi, Nalini R Shastri   +3 more
doaj   +2 more sources

RETRACTED: Preparation and Characterization of Spherical Amorphous Solid Dispersion with Amphotericin B

Pharmaceutics, 2018
In the present study, new polymer microspheres of amphotericin B (AmB) were prepared by a spray drying technique using cyclodextrin polymers (Poly-CD) to improve the solubility and dissolution of AmB, to prevent in vivo toxic AmB aggregations ...
Lyes Mehenni, Malika Lahiani-Skiba, Guy Ladam, François Hallouard, Mohamed Skiba   +4 more
doaj   +2 more sources

Drug-excipient behavior in polymeric amorphous solid dispersions [PDF]

Journal of Excipients and Food Chemicals, 2016
Amorphous drug delivery systems are increasingly utilized to enhance aqueous solubility and oral bioavailability. However, they lack physical and/or chemical stability.
Surikutchi Bhanu Teja, Shashank Pralhad Patil, Ganesh Shete, Sarsvatkumar Patel, Arvind Kumar Bansal   +4 more
doaj   +1 more source

Amorphous Solid Dispersion as Drug Delivery Vehicles in Cancer. [PDF]

Polymers (Basel), 2023
Cancer treatment has improved over the past decades, but a major challenge lies in drug formulation, specifically for oral administration. Most anticancer drugs have poor water solubility which can affect their bioavailability.
Budiman A, Handini AL, Muslimah MN, Nurani NV, Laelasari E, Kurniawansyah IS, Aulifa DL.   +6 more
europepmc   +2 more sources

The amorphous solid dispersion of the poorly soluble ABT-102 forms nano/microparticulate structures in aqueous medium: impact on solubility

International Journal of Nanomedicine, 2012
Kerstin J Frank,1,3 Ulrich Westedt,2 Karin M Rosenblatt,2 Peter Hölig,2 Jörg Rosenberg,2 Markus Mägerlein,2 Gert Fricker,3 Martin Brandl11Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense ...
Frank KJ, Westedt U, Rosenblatt KM, Hölig P, Rosenberg J, Mägerlein M, Fricker G, Brandl M   +7 more
doaj   +1 more source

Co-amorphous solid dispersion systems of lacidipine-spironolactone with improved dissolution rate and enhanced physical stability

Asian Journal of Pharmaceutical Sciences, 2019
Co-amorphous solid dispersion (C-ASD) systems have attracted great attention to improve the solubility of poorly soluble drugs, but the selection of an appropriate stabilizer to stabilize amorphous forms is still a huge challenge. Herein, C-ASD system of
Zhaomeng Wang, Mengchi Sun, Tian Liu, Zisen Gao, Qing Ye, Xiao Tan, Yanxian Hou, Jin Sun, Dun Wang, Zhonggui He   +9 more
doaj   +2 more sources

Itraconazole solid dispersion prepared by a supercritical fluid technique: preparation, in vitro characterization, and bioavailability in beagle dogs

Drug Design, Development and Therapy, 2015
Xuezhi Yin,1,3 Linda Sharon Daintree,2 Sheng Ding,3 Daniel Mark Ledger,2 Bing Wang,3 Wenwen Zhao,2 Jianping Qi,1 Wei Wu1 1Department of Pharmaceutics, School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery of Ministry of Education ...
Yin X, Daintree LS, Ding S, Ledger DM, Wang B, Zhao W, Qi J, Wu W   +7 more
doaj   +1 more source

Selecting the most appropriate formulation excipient for manufacture of amorphous solid dispersions: a case study of lumefantrine

British Journal of Pharmacy, 2022
This work demonstrated the importance of pre-formulation studies and proposed a generalised scheme for excipient screening in the early stage of amorphous solid dispersion(ASD) system development by profiling the excipients’ capability to solubilise ...
Dijia Liu, Shu Li, David Jones, Gavin Paul Andrews   +3 more
doaj   +1 more source