Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies [PDF]
Acta Pharmaceutica Sinica B, 2021 Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and bioavailability of poorly water-soluble drugs. Various approaches have been employed to produce ASDs and novel techniques are emerging.
Sonal V. Bhujbal +8 more
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Cellulose based polymers in development of amorphous solid dispersions
Asian Journal of Pharmaceutical Sciences, 2019 Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of ...
Rahul B Chavan +3 more
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Amorphous Solid Dispersion as Drug Delivery Vehicles in Cancer [PDF]
Polymers, 2023 Cancer treatment has improved over the past decades, but a major challenge lies in drug formulation, specifically for oral administration. Most anticancer drugs have poor water solubility which can affect their bioavailability.
Arif Budiman +2 more
exaly +3 more sources
Optimization of amorphous solid dispersion techniques to enhance solubility of febuxostat [PDF]
Folia Medica, 2021 Febuxostat is a selective inhibitor of xanthine oxidase and belongs to BCS class II drugs having low solubility and high permeability. Solubility is the most important parameter which directly affects dissolution, absorption and bioavailability of the ...
Vaishali P. Patel +2 more
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Asian Journal of Pharmaceutical Sciences, 2019 Co-amorphous solid dispersion (C-ASD) systems have attracted great attention to improve the solubility of poorly soluble drugs, but the selection of an appropriate stabilizer to stabilize amorphous forms is still a huge challenge. Herein, C-ASD system of
Zhaomeng Wang +9 more
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Thermal Stability of Amorphous Solid Dispersions [PDF]
Molecules, 2021 Amorphous solid dispersion drug delivery systems (ASD DDS) were proved to be efficient for the enhancement of solubility and bioavailability of poorly water-soluble drugs.
Dijana Jelić
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Разработка и регистрация лекарственных средств, 2023 Introduction. Ebastine is a second-generation antihistamine drug available in the form of orally disintegrating tablets and film-coated tablets. Ebastine substance exhibits high bioavailability, but low solubility in water and gastrointestinal tract ...
K. A. Gusev +7 more
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Pre-Processing a Polymer Blend into a Polymer Alloy by KinetiSol Enables Increased Ivacaftor Amorphous Solid Dispersion Drug Loading and Dissolution [PDF]
Biomedicines, 2023 This study compares the effects of pre-processing multiple polymers together to form a single-phase polymer alloy prior to amorphous solid dispersion formulation.
Stephen A. Thompson +4 more
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Co-Amorphous Solid Dispersion System for Improvement in Dissolution Profile of N-(((1r,4r)-4-((6-fluorobenzo[d]oxazol-2-yl)amino)cyclohexyl)methyl)-2-methylpropane-2-sulfonamide as a Neuropeptide Y5 Receptor Antagonist [PDF]
PharmaceuticsBackground/Objectives: Brick dust molecules exhibit high melting points and ultralow solubility. Overcoming this solubility issue is challenging. Previously, we formulated a co-amorphous system for a neuropeptide Y5 receptor antagonist (NP) as a brick ...
Hironori Tanaka, Hiroshi Ueda
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Oral Delivery of Niclosamide as an Amorphous Solid Dispersion That Generates Amorphous Nanoparticles during Dissolution [PDF]
Pharmaceutics, 2022 Niclosamide is an FDA-approved anthelmintic that is being studied in clinical trials as a chemotherapeutic and broad-spectrum antiviral. Additionally, several other applications are currently in the preclinical stage.
Miguel O. Jara +7 more
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