Results 21 to 30 of about 117,514 (300)
The Stabilization of Amorphous Zopiclone in an Amorphous Solid Dispersion [PDF]
AAPS PharmSciTech, 2015 Zopiclone is a poorly soluble psychotherapeutic agent. The aim of this study was to prepare and characterize an amorphous form of zopiclone as well as the characterization and performance of a stable amorphous solid dispersion. The amorphous form was prepared by the well-known method of quench-cooling of the melt. The solid dispersion was prepared by a
Milne, Marnus +2 more
openaire +4 more sources
Pharmaceuticals, 2020 This study aimed to investigate the effect of polymers and storage relative humidity on amorphous rebamipide (RB) and its solid dispersion phase transformation using chemometrics based on multiple datasets.
Yuta Otsuka +5 more
doaj +1 more source
Solid lipid dispersion of calcitriol with enhanced dissolution and stability [PDF]
, 2011 Solid dispersion of calcitriol with lipophilic surfactants and triglycerides was developed by melt-mixing method to modify the release and enhance stability of the drug. The solid dispersions were characterized by differential scanning calorimetry (DSC),
Yuan, Ting +6 more
core +1 more source
Cellulose based polymers in development of amorphous solid dispersions
Asian Journal of Pharmaceutical Sciences, 2019 Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of ...
Rahul B Chavan +3 more
doaj +1 more source
Modelling phase separation in amorphous solid dispersions [PDF]
Acta Biomaterialia, 2019 Much work has been devoted to analysing thermodynamic models for solid dispersions with a view to identifying regions in the phase diagram where amorphous phase separation or drug recrystallization can occur. However, detailed partial differential equation non-equilibrium models that track the evolution of solid dispersions in time and space are ...
Meere Martin +2 more
openaire +5 more sources
Preparation and characterization of spray-dried valsartan-loaded Eudragit® E PO solid dispersion microparticles [PDF]
, 2016 The purpose of this study was to develop the immediate release stomach-specific spray-dried formulation of valsartan (VAL) using Eudragit® E PO (EPO) as the carrier for enhancing dissolution rate in a gastric environment.
Taylor +21 more
core +6 more sources
Solid-state characterization of Felodipine–Soluplus amorphous solid dispersions [PDF]
Drug Development and Industrial Pharmacy, 2015 The aim of the current study is to develop amorphous solid dispersion (SD) via hot melt extrusion technology to improve the solubility of a water-insoluble compound, felodipine (FEL). The solubility was dramatically increased by preparation of amorphous SDs via hot-melt extrusion with an amphiphilic polymer, Soluplus® (SOL).
Jiannan, Lu +7 more
openaire +2 more sources
Use of Solid Dispersion Systems in Pharmacy
Конденсированные среды и межфазные границы, 2020 An overview of the use of solid dispersion systems in pharmacy is presented. The main techniques of obtaining solid dispersions were considered. The simplest one is the solvent removal technique: the medicinal drug and the carrier are dissolved in the ...
Sof ’ya Yu. Silaeva +6 more
doaj +1 more source
Automation potential of a new, rapid, microscopy based method for screening drug-polymer solubility [PDF]
, 2020 For the pharmaceutical industry, the preformulation screening of the compatibility of drug and polymeric excipients can often be time-consuming because of the use of trial-and-error approaches.
Alhijjaj, Muqdad +4 more
core +1 more source
Asian Journal of Pharmaceutical Sciences, 2015 Solid dispersion is one of the most promising strategies to improve oral bioavailability of poorly soluble API. However, there are inconsistent dissolution performances of solid dispersion reported which entails further investigation.
Siok-Yee Chan +4 more
doaj +1 more source