Results 41 to 50 of about 117,514 (300)

Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement

ADMET and DMPK, 2023
Introduction: Olanzapine (OLZ) is a psychotropic class drug commonly used to treat schizophrenia, bipolar disorder, and acute manic episodes. It has less water solubility, resulting in a slow dissolution rate and oral bioavailability.
Leena Patil, Umakant Verma, Rahul Rajput, Pritam Patil, Anniruddha Chaterjee, Jitendra B. Naik   +5 more
doaj   +1 more source

Spray drying formulation of amorphous solid dispersions

Advanced Drug Delivery Reviews, 2016
Spray drying is a well-established manufacturing technique which can be used to formulate amorphous solid dispersions (ASDs) which is an effective strategy to deliver poorly water soluble drugs (PWSDs). However, the inherently complex nature of the spray drying process coupled with specific characteristics of ASDs makes it an interesting area to ...
Singh, Abhishek, Van den Mooter, Guy
openaire   +4 more sources

Preparation and characterization of solid dispersion freeze-dried efavirenz – polyvinylpyrrolidone K-30

Journal of Advanced Pharmaceutical Technology & Research, 2016
The aim of this research is to prepare and characterize solid dispersion of efavirenz – polyvinylpyrrolidone (PVP) K-30 by freeze drying to increase its solubility.
Lili Fitriani, Alianshar Haqi, Erizal Zaini   +2 more
doaj   +1 more source

Normal modes, and acoustic properties, of an elastic solid with line defects

, 2014
The normal modes of a continuum solid endowed with a random distribution of line defects that behave like elastic strings are described. These strings interact with elastic waves in the bulk, generating wave dispersion and attenuation.
Lund, Fernando
core   +2 more sources

Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva [PDF]

, 2019
Sublingual film dosage forms for drugs used for fast symptomatic treatment have promise because they allow a rapid onset of action. The aim of this study was to prepare films of silodosin intended for sublingual administration for the symptomatic ...
Adair, Alhayali, Allam, Alonzo, Boateng, Brady, Brouwers, Campisi, Chapple, Curatolo, De Caro, El-Setouhy, ElMeshad, Gao, Garsuch, Gittings, Guo, Hanif, Hobbs, Huang, Humphrey, Jug, Kalia, Kapoor, Kim, Koland, Korhonen, Li, Liew, Madhav, Mashru, Matsubara, Miller-Chou, Montorsi, Nagy, Patel, Prabhu, Prasad, Preis, Preis, Preis, Radebaugh, Repka, Rossi, Runja, Sharma, Singh, Singh, Singh, Singh, Slavkova, Tanno, Vila, Visser, Vuddanda, Vuddanda, Yang, Zhang   +57 more
core   +2 more sources

Discontinuous shear modulus determines the glass transition temperature

, 2015
A solid - amorphous or crystalline - is defined by a finite shear modulus while a fluid lacks such. We thus experimentally investigate the elastic properties of a colloidal glass former near the glass transition: spectroscopy of vibrational excitations ...
Keim, Peter, Klix, Christian L., Maret, Georg   +2 more
core   +2 more sources

Laser irradiation to produce amorphous pharmaceuticals [PDF]

, 2016
Using a high-power CO2 laser to irradiate powder beds, it was possible to induce phase transformation to the amorphous state. Irradiation of a model drug, indometacin, resulted in formation of a glass.
Basit, AW, Gaisford, S, Tankul, J, Titapiwatanakun, V   +3 more
core   +1 more source

Myricetin Amorphous Solid Dispersions—Antineurodegenerative Potential

Molecules
Our research aimed to develop an amorphous solid dispersion (ASD) of myricetin (MYR) with Polyvinylpyrrolidone K30 (PVP30) to enhance its solubility, dissolution rate, antioxidant, and neuroprotective properties. Employing a combination of solvent evaporation and freeze drying, we successfully formed MYR ASDs.
Natalia Rosiak, Ewa Tykarska, Judyta Cielecka-Piontek   +2 more
openaire   +3 more sources

Comparative study of the potential of poly(2-ethyl-2-oxazoline) as carrier in the formulation of amorphous solid dispersions of poorly soluble drugs [PDF]

, 2019
Despite the fact that solid dispersions are gaining momentum, the number of polymers that have been used as a carrier during the past 50 years is rather limited.
Boel, Eline, De la Rosa, Victor, Hoogenboom, Richard, Smeets, Annelies, Van den Mooter, Guy, Vergaelen, Maarten   +5 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source