Results 111 to 120 of about 2,406 (250)

Clinical pharmacokinetics of an amorphous solid dispersion tablet of elacridar

Drug Delivery and Translational Research, 2016
Elacridar is an inhibitor of the permeability glycoprotein (P-gp) and the breast cancer resistance protein (BCRP) and is a promising absorption enhancer of drugs that are substrates of these drug-efflux transporters. However, elacridar is practically insoluble in water, resulting in low bioavailability which currently limits its clinical application ...
Emilia Sawicki, Remy B. Verheijen, Alwin D.R. Huitema, Olaf van Tellingen, Jan H.M. Schellens, Bastiaan Nuijen, Jos H. Beijnen, Neeltje Steeghs   +7 more
openaire   +4 more sources

Electrode and Microstructure Dependence of Oxygen Diffusion in Ferroelectric Hafnium Zirconium Oxide Thin Films

Advanced Functional Materials, EarlyView.
Significant nanoscale oxygen diffusion coefficient variations are measured in ferroelectric hafnium zirconium oxide films with grain boundaries and electrode interfaces exhibiting values 104 times larger than the grain cores. Overall coefficients are 10X larger for films prepared with metal nitride electrodes compared to refractory metals. New insights
Liron Shvilberg, Thomas W. Pfeifer, Chuanzhen Zhou, Yong Kyu Choi, Duk‐Hyun Choe, Patrick E. Hopkins, Jon F. Ihlefeld   +6 more
wiley   +1 more source

Tuning Separator Chemistry: Improving Zn Anode Compatibility via Functionalized Chitin Nanofibers

Advanced Functional Materials, EarlyView.
Nanochitin derived from waste shrimp shells is used to fabricate separators for aqueous zinc batteries. By tuning the density of amine and carboxylic surface groups, water mobility at the separator interface is controlled, promoting uniform zinc deposition, suppressing dendrite growth, and enabling exceptional cycling stability exceeding 2000 h ...
Ibrahim Al Kathemi, Vishnu Arumughan, Mohamed Zbiri, Marcel Kröger, Ira Smal, Eero Kontturi, Roza Bouchal   +6 more
wiley   +1 more source

Hot melt extruded amorphous solid dispersions containing lumefantrine and Soluplus

Over the last 15 years, a small number of paediatric artemisinin-based combination therapy products have been marketed. These included Riamet® and Coartem® dispersible tablets, a combination of artemether and lumefantrine, co-developed by the Medicines ...
Gu, Wenjie, Boulet, Pascal, Johnson, Lindsay M., Andrews, Gavin, P, Gallas, Mael, Jones, David, Andrews, Gavin P., Zhang, Zian, Zhang, Zi’an, Li, Shu, de Margerie, Victoire, Johnson, Lindsay, M   +11 more
core   +1 more source

Graded‐Interface Dual‐Environment Hydrogel‐Polymer Electrolyte for Stabilized Anode and Sustained Cathode Kinetics in Aqueous Zinc‐Ion Batteries

Advanced Functional Materials, EarlyView.
A graded‐interface hydrogel‐polymer electrolyte decouples water activity to simultaneously stabilize the Zn anode and sustain cathode kinetics. The flexible design supports dendrite‐free cycling over 1600 h, high capacity in both MnO2 and V2O5 full cells, and stable pouch‐cell performance under bending, resolving the fundamental water conflict in ...
Shuyun Wang, Shengmei Chen, Xinyu Wang, Haipeng Wang, Jinsong Zhou, Ka Kiu Keith Cheung, Yiran Ying, Longtao Ma, Juan Antonio Zapien   +8 more
wiley   +1 more source

Tailoring Li‐ion Storage and Transport in Two‐Dimensional Conjugated Metal‐Organic Frameworks via Precise Nitrogen Incorporation

Advanced Functional Materials, EarlyView.
Two nitrogen‐doped 2D conjugated metal‐organic frameworks (2D c‐MOFs, namely Cu‐Nx‐OHBA, x = 2 or 4) are synthesized, featuring precise nitrogen incorporation via rational ligand design. The Cu‐Nx‐OHBA 2D c‐MOFs are largely tailorable by varying skeletal nitrogen density, with respect to electrical conductivity, Li‐storage capacitance, and Li‐transport
Xiangyu Li, Shaoze Shi, Fucai Cui, Rashid Iqbal, Pengyu Wang, Tianrui Wu, Jingcheng Hao, Renhao Dong   +7 more
wiley   +1 more source

Dissolution behavior of amorphous solid dispersions

, 2015
Current drug discovery techniques tend to identify potential new drug entities with more complex structures which may pose significant formulation challenges.
Jackson, Matthew J, Jackson, Matthew James   +1 more
core  

An investigation into the solubility and stability of amorphous solid dispersions of BCS class II drugs [PDF]

, 2018
The poor water solubility of many drugs has emerged as one of the major challenges in the pharmaceutical world. Amorphous solid dispersions (ASDs) are one of the most widely used formulation strategies for the enhancement of in-vitro and in-vivo ...
Fox, Helen, O'Reilly, Niall, Baghel, Shrawan   +2 more
core  

Analysis of Amorphous Solid Dispersions Using 2D Solid-State NMR and ¹H T₁ Relaxation Measurements

, 2016
Solid-state NMR (SSNMR) can provide detailed structural information about amorphous solid dispersions of pharmaceutical small molecules. In this study, the ability of SSNMR experiments based on dipolar correlation, spin diffusion, and relaxation ...
Jacalyn S. Clawson (2261926), Mark Strohmeier (1757743), Tran N. Pham (1985929), Frederick G. Vogt (1757755), Manisha Chavda (2261920), Andrew J. Edwards (2261923), Simon A. Watson (1717216)   +6 more
core   +1 more source

A Bilayered Inorganic‐Metal Interface Enables Highly Reversible Aluminum Deposition for Long‐Life Aqueous Batteries

Advanced Functional Materials, EarlyView.
A gradient M/MOx (M = Sn, Cu, Cd) synergistic interphase was constructed on Al via a one‐step displacement reaction. This interphase leverages high aluminophilicity and ion‐buffering capability to accelerate desolvation, enhance Al3+ transport, and suppress side reactions, enabling ultrastable symmetric cell operation at 0.05 mA cm−2 for 1800 h with an
Shuang Cheng, Xiaomin Cheng, Linge Li, Yaping Wang, Jing Zhang, Yongzheng Zhang, Hongzhen Lin, Jian Wang   +7 more
wiley   +1 more source