Results 121 to 130 of about 2,373,510 (375)
State based model of long-term potentiation and synaptic tagging and capture [PDF]
, 2009 Recent data indicate that plasticity protocols have not only synapse-specific but also more widespread effects. In particular, in synaptic tagging and capture (STC), tagged synapses can capture plasticity-related proteins, synthesized in response to ...
A Govindarajan +50 more
core +4 more sources
Cytotoxicity of 19 Pesticides in Rainbow Trout Gill, Liver, and Intestinal Cell Lines
Environmental Toxicology and Chemistry, EarlyView.Abstract The rainbow trout gill cell line (RTgill‐W1), via test guideline 249 of the Organisation for Economic Co‐operation and Development, has been established as a promising New Approach Methodology, although to advance confidence in the method more case studies are needed that: 1) expand our understanding of applicability domains (chemicals with ...
Sophie Emberley‐Korkmaz +4 more
wiley +1 more source
Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains
eLife, 2017 Ion conductivity and the gating characteristics of tetrameric glutamate receptor ion channels are determined by their subunit composition. Competitive homo- and hetero-dimerization of their amino-terminal domains (ATDs) is a key step controlling assembly.
Huaying Zhao +5 more
doaj +1 more source
Inhibition of Food Intake by PACAP in the Hypothalamic Ventromedial Nuclei is Mediated by NMDA Receptors [PDF]
, 2014 Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the
Choi, Sujean +3 more
core +2 more sources
Food Frontiers, EarlyView.PDIA4 is significantly upregulated in response to nutrient overload in pancreatic β‐cells, resulting in aberrant ROS production, β‐cell failure, and diabetes. PDIA4 facilitates cancer development by inhibiting caspase‐mediatedcell death in cancer and promoting VEGF‐mediated protumoral immunity andangiogenesis in the tumor microenvironment, highlighting
Yi‐San Lee +4 more
wiley +1 more source
Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition
Nature, 2021 Jie Yu +5 more
semanticscholar +1 more source
Hypothalamic Astrocytes Exhibit Glycolytic Features Making Them Prone for Glucose Sensing
Glia, EarlyView.Hypothalamic astrocytes versus cortical astrocytes: are more glycolytic due to high Pkm2, Glut1 and Mct4 expression do not exhibit glutamate‐induced glycolysis detect glucose concentration variations via an AMPK sensor with altered lactate production. ABSTRACT In the hypothalamus, detection of energy substrates such as glucose is essential to regulate ...
Sarah Geller +11 more
wiley +1 more source
The mechanisms in glucose metabolism of aging hippocampus
Ibrain, EarlyView.Cognitive decline in elders stems from the irreversible loss and functional decline of neurons, with the hippocampus being particularly susceptible to age‐related neuronal deterioration. Glucose acts as the primary fuel for the brain, and a constant provision of glucose to the hippocampus is essential for memory and cognitive functions.
Rui He +6 more
wiley +1 more source
Disease Models & Mechanisms, 2019 Loss-of-function mutations in a human AMPA receptor-associated protein, ferric chelate reductase 1-like (FRRS1L), are associated with a devastating neurological condition incorporating choreoathetosis, cognitive deficits and epileptic encephalopathies ...
Michelle Stewart +12 more
doaj +1 more source
Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons
Journal of Neuroscience, 1996 The AMPA receptor, which is involved in most fast glutamatergic transmission in the mammalian brain and is expressed in most neurons, is made up of four subunits, GluR1–4.
R. Wenthold +3 more
semanticscholar +1 more source