Results 131 to 140 of about 99,629 (284)

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Increased Hippocampal AMPA and NMDA Receptor Subunit Immunoreactivity in Temporal Lobe Epilepsy Patients [PDF]

, 1998
Gary W. Mathern, James K. Pretorius, Delia Mendoza, Alana Lozada, João Pereira Leite, Leila Chimelli, Itzhak Fried, Américo Ceiki Sakamoto, João Alberto Assirati, P. David Adelson   +9 more
openalex   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Distinct impacts of sodium channel blockers on the strength–duration properties of human motor cortex neurons

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to determine how voltage‐gated sodium channel (VGSC) blockers modulate cortical excitability in vivo. VGSCs are critical for regulating axonal excitability, yet the effects of sodium channel‐blocking medications on human cortical neurons remain poorly characterized.
Lorenzo Rocchi, Kate Brown, Alessandro Di Santo, Hannah Smith, Angel V. Peterchev, John C. Rothwell, Ricci Hannah   +6 more
wiley   +1 more source

Persistent phosphorylation parallels long-term desensitization of cerebellar purkinje cell AMPA-type glutamate receptors. [PDF]

, 1997
Kazu Nakazawa, Sumiko Mikawa, M. Ito
openalex   +1 more source

WONOEP XVII appraisal: Targeting network excitability beyond the synapse ‐Neurotransmitter, ionic, and electro ‐diffusions

Epilepsia, EarlyView.
Abstract Epilepsy affects approximately 1% of the population worldwide, and although medications are effective in the majority of cases, seizures persist in approximately 30% of patients. Despite the effort to develop new antiseizure drugs, the rate of pharmacoresistance in patients has not diminished over the past 3 decades. There is thus a real unmet
Vincent Magloire, Marco de Curtis, Jeffrey Noebels, Gilles Huberfeld, Piotr Suffczynski, Vadym Gnatkovsky, Olga Tyurikova, Dominique Durand, David C. Henshall, Cian McCafferty   +9 more
wiley   +1 more source

Electrical stimulation of stem cell–derived human neural networks for evaluating anti‐seizure medications

Epilepsia, EarlyView.
Abstract Objective Current preclinical epilepsy drug screening relies on animal models that poorly reflect human neurophysiology, leading to high failure rates in clinical translation. We aimed to establish a human in vitro model using human‐induced pluripotent stem cell (hiPSC)–derived cortical neurons cultured on multielectrode arrays (MEAs), capable
Joshua Nicholls, Jinchao Gu, Zhibin Chen, Zikou Liu, Ana Antonic‐Baker, Muhammad Shahid Javaid, Eliza Moore, Hailin Zhu, Afaf Altalhi, David K. Wright, Huseyin Sumer, Terence J. O'Brien, Patrick Kwan, Ben Rollo   +13 more
wiley   +1 more source

Stimulation of Dopamine D4 Receptors in the Nucleus Accumbens Shell Increases Palatable Food Intake in Satiated Male Rats: Modulation by NMDA and AMPA Receptors

Brain Sciences
Background/Objectives: Palatability significantly influences food consumption, often leading to overeating and obesity by activating the brain’s reward systems.
Refugio Cruz-Trujillo, Daniel Díaz-Urbina, José Alfredo Díaz-Gandarilla, Dolores Guadalupe Vidal-López, Rodrigo Erick Escartín-Pérez, Juan Manuel Mancilla-Diaz, Benjamín Florán, Juan Gabriel Tejas-Juárez   +7 more
doaj   +1 more source

Topiramate for the treatment of neonatal seizures and beyond

Epilepsia, EarlyView.
Abstract Acute symptomatic neonatal seizures are one of the most common neurological disorders in newborns admitted to neonatal intensive care units and require prompt treatment. Up to 50% of neonatal seizures are refractory to first‐line medications such as phenobarbital (PB), and another 30% fail second‐line therapy.
Wolfgang Löscher, Janet S. Soul
wiley   +1 more source

The discovery of YM900 and its pharmacological characterization as a selective and potent α-amino-3-hydroxy-5-methylisoxazole-4-propionate(AMPA) receptor antagonist.

, 1993
Masao Shimizu‐Sasamata, Masamichí Okada, Shuichi Sakamoto, Sachiko Kawasaki, Kazuo Koshiya, Shinji Usuda, Kiyoshi Murase   +6 more
openalex   +1 more source