Results 141 to 150 of about 2,334,241 (398)

Synapse elimination and learning rules co-regulated by MHC class I H2-Db. [PDF]

, 2014
The formation of precise connections between retina and lateral geniculate nucleus (LGN) involves the activity-dependent elimination of some synapses, with strengthening and retention of others. Here we show that the major histocompatibility complex (MHC)
Adelson, Jaimie, Brott, Barbara, Cheng, Sarah, Datwani, Akash, Feller, Marla, Kirkby, Lowry, Lee, Hanmi, Shatz, Carla   +7 more
core   +3 more sources

Preclinical pharmacology of perampanel, a selective non‐competitive AMPA receptor antagonist

Acta Neurologica Scandinavica, Supplementum, 2013
Perampanel [2‐(2‐oxo‐1‐phenyl‐5‐pyridin‐2‐yl‐1,2‐dihydropyridin‐3‐yl)benzonitrile; E2007] is a potent, selective, orally active non‐competitive AMPA receptor antagonist developed for the treatment of epilepsy.
Michael A. Rogawski, Takahisa Hanada
semanticscholar   +1 more source

Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities

Disease Models & Mechanisms, 2019
Loss-of-function mutations in a human AMPA receptor-associated protein, ferric chelate reductase 1-like (FRRS1L), are associated with a devastating neurological condition incorporating choreoathetosis, cognitive deficits and epileptic encephalopathies ...
Michelle Stewart, Petrina Lau, Gareth Banks, Rasneer Sonia Bains, Enrico Castroflorio, Peter L. Oliver, Christine L. Dixon, Michael C. Kruer, Dimitri M. Kullmann, Abraham Acevedo-Arozena, Sara E. Wells, Silvia Corrochano, Patrick M. Nolan   +12 more
doaj   +1 more source

Activity-regulated RNA editing in select neuronal subfields in hippocampus [PDF]

, 2012
RNA editing by adensosine deaminases is a widespread mechanism to alter genetic information in metazoa. In addition to modifications in non-coding regions, editing contributes to diversification of protein function, in analogy to alternative splicing ...
Ales Balik, Altschul, Andrew C. Penn, Aruscavage, Bass, Birney, Bratt, Brorson, Coleman, Coleman, Daniel, Darty, Dawson, de la Mata, Feldmeyer, Feng, Fisahn, Gahwiler, Gainey, Gallo, Ge, Goodman, Greger, Greger, Greger, Gurevich, Hamada, Hideyama, Hideyama, Higuchi, Higuchi, Hoopengardner, Hundley, Ingo H. Greger, Jepson, Katoh, Kent, Lee, Lein, Li, Liu, Lomeli, Maas, Marcucci, Palladino, Paul, Peng, Peng, Penn, Penn, Penn, Pozo, Rosenthal, Rueter, Ryman, Sanjana, Schoft, Seeburg, Seeburg, Sommer, Sommer, Stefl, Stefl, Tariq, Toth, Traynelis, Turrigiano, Turrigiano, Valente, Venkatesh, Wang, Witter, Xie, Zsofia Nemoda   +73 more
core   +1 more source

Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition

Nature, 2021
Jie Yu, P. Rao, Sarah Clark, Jaba Mitra, T. Ha, E. Gouaux   +5 more
semanticscholar   +1 more source

Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons

Journal of Neuroscience, 1996
The AMPA receptor, which is involved in most fast glutamatergic transmission in the mammalian brain and is expressed in most neurons, is made up of four subunits, GluR1–4.
R. Wenthold, RS Petralia, II Blahos J, A. Niedzielski   +3 more
semanticscholar   +1 more source

Self‐limited familial focal epilepsy caused by ANK2 variants: A potentially under‐recognized condition

Epilepsia Open, EarlyView.
Abstract The Ankyrin 2 (ANK2) gene encodes the ankyrin‐B protein (ANKB), which is involved in the organization and stability of membrane ion channels, transporters, and receptors in cardiomyocytes and neurons. Variants in ANK2 genes are initially reported in long QT syndrome and autism.
Po‐Hsi Lin, Chen‐Jui Ho, Chih‐Hsiang Lin, Ya‐Yuan Hou, Cheng‐Han Chan, Meng‐Han Tsai   +5 more
wiley   +1 more source

A neuroeconomic theory of bidirectional synaptic plasticity and addiction [PDF]

arXiv, 2011
Neuronal mechanisms underlying addiction have been attracting attention in neurobiology, economics, neuropsychiatry, and neuroeconomics. This paper proposes a possible link between economic theory of addiction (Becker and Murphy, 1988) and neurobiological theory of bidirectional synaptic plasticity (Bienenstock, Cooper, Munro, 1982) based on recent ...
arxiv  

Hypothalamic excitatory amino acid receptors mediate stress-induced tachycardia in rats [PDF]

, 1992
The role of hypothalamic excitatory amino acid (EAA) receptors in mediating the cardiovascular response to stress was examined using conscious chronically instrumented rats.
DiMicco, Joseph A., Soltis, Robert P.
core   +2 more sources

Cytotoxicity of 19 Pesticides in Rainbow Trout Gill, Liver, and Intestinal Cell Lines

Environmental Toxicology and Chemistry, EarlyView.
Abstract The rainbow trout gill cell line (RTgill‐W1), via test guideline 249 of the Organisation for Economic Co‐operation and Development, has been established as a promising New Approach Methodology, although to advance confidence in the method more case studies are needed that: 1) expand our understanding of applicability domains (chemicals with ...
Sophie Emberley‐Korkmaz, Krittika Mittal, Na'im Temlock, Jessica Head, Niladri Basu   +4 more
wiley   +1 more source