Results 161 to 170 of about 2,414,431 (351)

Treatment approaches in posthypoxic myoclonus: A narrative review with expert opinion

Epilepsia, EarlyView.
Abstract Acute posthypoxic myoclonus (PHM) is a neurological complication that typically emerges within 12–48 h following cardiac arrest, often in comatose patients. It can present as generalized, multifocal, or focal myoclonus and has traditionally been associated with poor prognosis.
Marina Romozzi, Federico Tosto, David García‐Azorín, Luigi Francesco Iannone, Catello Vollono, Paolo Calabresi, Juan Luis Alcala‐Zermeno, Michael R. Sperling   +7 more
wiley   +1 more source

Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting

Science, 2019
Ankit Awasthi, Binu Ramachandran, Saheeb Ahmed, E. Benito, Y. Shinoda, Noam Nitzan, A. Heukamp, Sabine Rannio, H. Martens, Jonas Barth, K. Burk, Y. T. Wang, A. Fischer, Camin Dean   +13 more
semanticscholar   +1 more source

3′UTR variants of ALS‐linked RNAs modify subcellular and cellular phenotypes

The FEBS Journal, EarlyView.
Our study demonstrates that alternative 3′UTR variants of ALS‐linked transcripts modulate subcellular RNA localization and cytoskeletal architecture. NEFH 3′UTR‐Long promotes nuclear RNA clustering, while SOD1 3′UTR‐Long reduces filopodia formation. These results suggest that 3′UTRs, independent of coding sequences, can influence neuronal phenotypes ...
Melis Savasan‐Sogut, Danae Campos‐Melo, Michael J. Strong   +2 more
wiley   +1 more source

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source

Variability of Neurotransmitter Concentration and Nonsaturation of Postsynaptic AMPA Receptors at Synapses in Hippocampal Cultures and Slices [PDF]

, 1999
Guogsong Liu, Sukwoo Choi, Richard W. Tsien   +2 more
openalex   +1 more source

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

A Scoping Review of Corticosterone-Induced Changes in Ionotropic Glutamate Receptor Levels and Localization in the Rodent Brain: Implications for the Auditory System

Brain Sciences
Background: The ionotropic glutamate receptor AMPA (AMPAR) mediates fast excitatory synaptic transmission and regulates synaptic strength in various parts of the CNS.
Elsa Edlund, Ewa Domarecka, Heidi Olze, Agnieszka Szczepek   +3 more
doaj   +1 more source

Vesicular glutamatergic transmission in noise-induced loss and repair of cochlear ribbon synapses [PDF]

, 2019
Noise-induced excitotoxicity is thought to depend on glutamate. However, the excitotoxic mechanisms are unknown, and the necessity of glutamate for synapse loss or regeneration is unclear. Despite absence of glutamatergic transmission from cochlear inner
Carlquist, Jason, Davis, Bethany, Fitzpatrick, James A.J., Gantz, Jay A, Hirose, Keiko, Kallogjeri, Dorina, Kim, Kyunghee X, Li, Song-Zhe, Ohlemiller, Kevin K, Payne, Shelby, Rutherford, Mark A, V-Ghaffari, Babak, Yang-Hood, Aizhen   +12 more
core   +1 more source

Excitotoxicity through Ca2+-permeable AMPA receptors requires Ca2+-dependent JNK activation

, 2010
Marta Vieira, Joana Fernandes, Ana Burgeiro, Gareth M. Thomas, Richard L. Huganir, Carlos B. Duarte, Ana Luı́sa Carvalho, Armanda E. Santos   +7 more
openalex   +2 more sources

Spontaneous Ca2+ signals in the developing mammalian cochlea of live mice under different anaesthetic regimes

Experimental Physiology, EarlyView.
Abstract The pre‐hearing mouse cochlea undergoes critical periods of spontaneous Ca2+‐dependent activity that spreads across non‐sensory supporting cells and inner hair cells (IHCs). These signals have been shown to regulate not only the refinement of neural circuits along the auditory pathway towards functional maturity, but also the maturation of the
Francesca De Faveri, Walter Marcotti, Federico Ceriani   +2 more
wiley   +1 more source