Results 161 to 170 of about 2,373,510 (375)
Epilepsia, EarlyView.Abstract Objective Current preclinical epilepsy drug screening relies on animal models that poorly reflect human neurophysiology, leading to high failure rates in clinical translation. We aimed to establish a human in vitro model using human‐induced pluripotent stem cell (hiPSC)–derived cortical neurons cultured on multielectrode arrays (MEAs), capable
Joshua Nicholls +13 more
wiley +1 more source
Topiramate for the treatment of neonatal seizures and beyond
Epilepsia, EarlyView.Abstract Acute symptomatic neonatal seizures are one of the most common neurological disorders in newborns admitted to neonatal intensive care units and require prompt treatment. Up to 50% of neonatal seizures are refractory to first‐line medications such as phenobarbital (PB), and another 30% fail second‐line therapy.
Wolfgang Löscher, Janet S. Soul
wiley +1 more source
Deciphering SCN2A: A comprehensive review of rodent models of Scn2a dysfunction
Epilepsia, EarlyView.Abstract SCN2A encodes for the alpha subunit of the voltage‐gated sodium channel NaV1.2, which is involved in action potential initiation and backpropagation in excitatory neurons. Currently, it is one of the highest monogenetic risk factors for both epilepsy and autism spectrum disorder.
Katelin E. J. Scott +2 more
wiley +1 more source
A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains
The FEBS Journal, EarlyView.Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley +1 more source
The AMPA Receptor Code of Synaptic Plasticity
Neuron, 2018 Graham H. Diering, R. Huganir
semanticscholar +1 more source
Neocortical neurogenesis: a proneural gene perspective
The FEBS Journal, EarlyView.The neocortex is a mammalian‐specific brain region responsible for higher‐order cognitive functioning that shares fundamental similarities across species, but which is larger and more complex in humans. Proneural genes, encoding basic helix–loop–helix transcription factors (TFs), are evolutionarily conserved drivers of neurogenesis from fly to human ...
Lakshmy Vasan +3 more
wiley +1 more source
Persistent phosphorylation parallels long-term desensitization of cerebellar purkinje cell AMPA-type glutamate receptors. [PDF]
, 1997 Kazu Nakazawa, Sumiko Mikawa, M. Ito
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Comparative analysis of androgen and estrogen receptor mRNA expression in adult mouse hippocampus
Journal of Neuroendocrinology, EarlyView.Abstract In hippocampus, androgens and estrogens influence neuronal plasticity via a range of nuclear or membrane‐bound receptors. While much work has focused on determining their functions, a certain vagueness about the cellular expression of established receptors has remained.
Malte Schöbe +2 more
wiley +1 more source
Vesicular glutamatergic transmission in noise-induced loss and repair of cochlear ribbon synapses [PDF]
, 2019 Noise-induced excitotoxicity is thought to depend on glutamate. However, the excitotoxic mechanisms are unknown, and the necessity of glutamate for synapse loss or regeneration is unclear. Despite absence of glutamatergic transmission from cochlear inner
Carlquist, Jason +12 more
core +1 more source
Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó +4 more
wiley +1 more source